Association between classes and subclasses of polyphenol intake and 5-year body weight changes in the EPIC-PANACEA study
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The aim of this study was to evaluate the associations among the intake of total polyphenols, polyphenol classes, and polyphenol subclasses and body weight change over 5 years.
Methods
A total of 349,165 men and women aged 25 to 70 years were recruited in the Physical Activity, Nutrition, Alcohol, Cessation of Smoking, Eating Out of Home and Obesity (PANACEA) project of the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort from nine European countries. Body weight was measured at baseline and at follow-up after a median time of 5 years. Polyphenol intake, including four main polyphenol classes and eighteen subclasses, was estimated using validated dietary questionnaires and Phenol-Explorer. Multilevel mixed linear regression models were used to estimate the associations.
Results
Participants gained, on average, 2.6 kg (±5.0 kg) over 5 years. Total flavonoids intake was inversely associated with body weight change (−0.195 kg/5 years, 95% CI: −0.262 to −0.128). However, the intake of total polyphenols (0.205 kg/5 years, 95% CI: 0.138 to 0.272) and intake of hydroxycinnamic acids (0.324 kg/5 years, 95% CI: 0.267 to 0.381) were positively associated with body weight gain. In analyses stratified by coffee consumption, hydroxycinnamic acid intake was positively associated with body weight gain in coffee consumers (0.379 kg/5 years, 95% CI: 0.319 to 0.440), but not in coffee nonconsumers (−0.179 kg/5 years, 95% CI: −0.490 to 0.133).
Conclusions
Higher intakes of flavonoids and their subclasses are inversely associated with a modest body weight change. Results regarding hydroxycinnamic acids in coffee consumers require further investigation.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Obesity |
| Vol/bind | 31 |
| Udgave nummer | 4 |
| Sider (fra-til) | 1146-1158 |
| Antal sider | 13 |
| ISSN | 1930-7381 |
| DOI | |
| Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
This study has been funded by Carlos III Health Institute through the project PI18/00191 (co‐funded by European Regional Development Fund [ERDF], a way to build Europe). The Physical Activity, Nutrition, Alcohol, Cessation of Smoking, Eating Out of Home and Obesity (PANACEA) project was funded by the European Union in the framework of the Public Health Programme (project number: 2005328). The coordination of European Prospective Investigation into Cancer and Nutrition (EPIC) is financially supported by International Agency for Research on Cancer (IARC) and also by the Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, which has additional infrastructure support provided by the National Institute for Health and Care Research (NIHR) Imperial Biomedical Research Centre (BRC). The national cohorts are supported by the following: Danish Cancer Society (Denmark); League Against Cancer, Gustave Roussy Institute, General Mutual of National Education, and the National Institute of Health and Medical Research (INSERM; France); German Cancer Aid, German Cancer Research Center (DKFZ), German Institute of Human Nutrition Potsdam‐Rehbruecke (DIfE), and the Federal Ministry of Education and Research (BMBF) (Germany); Italian Association for Cancer Research (AIRC), Company of Saint Paul, and the National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), and Statistics Netherlands (the Netherlands); Health Research Fund (FIS), Carlos III Institute of Health (ISCIII), Regional Governments of Andalucía, Asturias, Basque Country, Murcia, and Navarra, and the Catalan Institute of Oncology (ICO; Spain); Swedish Cancer Society, Swedish Research Council, and the County Councils of Skåne and Västerbotten (Sweden); Cancer Research UK (14136 to EPIC‐Norfolk; C8221/A29017 to EPIC‐Oxford) and Medical Research Council (MRC; 1000143 to EPIC‐Norfolk; MR/M012190/1 to EPIC‐Oxford; the UK). Nita G. Forouhi acknowledges support from MRC Epidemiology Unit (MC_UU_0006/3) and from the NIHR Cambridge Biomedical Research Centre diet, nutrition, and lifestyle theme (IS‐BRC‐1215‐20014). She is an NIHR Senior Investigator. The authors thank the Research Centers of Catalonia (CERCA) Program/Government of Catalonia for the institutional support to Bellvitge Biomedical Research Institute (IDIBELL). Jazmin Castañeda thanks the National Council for Science and Technology (CONACYT) predoctoral fellowship (identifier 693636). Mercedes Gil‐Lespinard, Enrique Almanza‐Aguilera, and Raul Zamora‐Ros were supported by the predoctoral contracts for training in research into health (PFIS) (FI19/00185), the “Sara Borrell” (CD20/00071), and the “Miguel Servet II” (CPII20/00009) programs from the Carlos III Institute of Health (cofunded by European Social Fund [ESF], investing in your future).
Publisher Copyright:
© 2023 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society.
ID: 338588434