Association between classes and subclasses of polyphenol intake and 5-year body weight changes in the EPIC-PANACEA study
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Association between classes and subclasses of polyphenol intake and 5-year body weight changes in the EPIC-PANACEA study. / Castañeda, Jazmin; Gil-Lespinard, Mercedes; Almanza-Aguilera, Enrique; Llaha, Fjorida; Gómez, Jesús Humberto; Bondonno, Nicola; Tjønneland, Anne; Overvad, Kim; Katzke, Verena; Schulze, Matthias B.; Masala, Giovanna; Agnoli, Claudia; Santucci de Magistris, Maria; Tumino, Rosario; Sacerdote, Carlotta; Skeie, Guri; Brustad, Magritt; Lasheras, Cristina; Molina-Montes, Esther; Chirlaque, María Dolores; Barricarte, Aurelio; Sonestedt, Emily; da Silva, Marisa; Johansson, Ingegerd; Hultdin, Johan; May, Anne M.; Forouhi, Nita G.; Heath, Alicia K.; Freisling, Heinz; Weiderpass, Elisabete; Scalbert, Augustin; Zamora-Ros, Raul.
I: Obesity, Bind 31, Nr. 4, 2023, s. 1146-1158.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Association between classes and subclasses of polyphenol intake and 5-year body weight changes in the EPIC-PANACEA study
AU - Castañeda, Jazmin
AU - Gil-Lespinard, Mercedes
AU - Almanza-Aguilera, Enrique
AU - Llaha, Fjorida
AU - Gómez, Jesús Humberto
AU - Bondonno, Nicola
AU - Tjønneland, Anne
AU - Overvad, Kim
AU - Katzke, Verena
AU - Schulze, Matthias B.
AU - Masala, Giovanna
AU - Agnoli, Claudia
AU - Santucci de Magistris, Maria
AU - Tumino, Rosario
AU - Sacerdote, Carlotta
AU - Skeie, Guri
AU - Brustad, Magritt
AU - Lasheras, Cristina
AU - Molina-Montes, Esther
AU - Chirlaque, María Dolores
AU - Barricarte, Aurelio
AU - Sonestedt, Emily
AU - da Silva, Marisa
AU - Johansson, Ingegerd
AU - Hultdin, Johan
AU - May, Anne M.
AU - Forouhi, Nita G.
AU - Heath, Alicia K.
AU - Freisling, Heinz
AU - Weiderpass, Elisabete
AU - Scalbert, Augustin
AU - Zamora-Ros, Raul
N1 - Publisher Copyright: © 2023 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society.
PY - 2023
Y1 - 2023
N2 - Objective: The aim of this study was to evaluate the associations among the intake of total polyphenols, polyphenol classes, and polyphenol subclasses and body weight change over 5 years. Methods: A total of 349,165 men and women aged 25 to 70 years were recruited in the Physical Activity, Nutrition, Alcohol, Cessation of Smoking, Eating Out of Home and Obesity (PANACEA) project of the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort from nine European countries. Body weight was measured at baseline and at follow-up after a median time of 5 years. Polyphenol intake, including four main polyphenol classes and eighteen subclasses, was estimated using validated dietary questionnaires and Phenol-Explorer. Multilevel mixed linear regression models were used to estimate the associations. Results: Participants gained, on average, 2.6 kg (±5.0 kg) over 5 years. Total flavonoids intake was inversely associated with body weight change (−0.195 kg/5 years, 95% CI: −0.262 to −0.128). However, the intake of total polyphenols (0.205 kg/5 years, 95% CI: 0.138 to 0.272) and intake of hydroxycinnamic acids (0.324 kg/5 years, 95% CI: 0.267 to 0.381) were positively associated with body weight gain. In analyses stratified by coffee consumption, hydroxycinnamic acid intake was positively associated with body weight gain in coffee consumers (0.379 kg/5 years, 95% CI: 0.319 to 0.440), but not in coffee nonconsumers (−0.179 kg/5 years, 95% CI: −0.490 to 0.133). Conclusions: Higher intakes of flavonoids and their subclasses are inversely associated with a modest body weight change. Results regarding hydroxycinnamic acids in coffee consumers require further investigation.
AB - Objective: The aim of this study was to evaluate the associations among the intake of total polyphenols, polyphenol classes, and polyphenol subclasses and body weight change over 5 years. Methods: A total of 349,165 men and women aged 25 to 70 years were recruited in the Physical Activity, Nutrition, Alcohol, Cessation of Smoking, Eating Out of Home and Obesity (PANACEA) project of the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort from nine European countries. Body weight was measured at baseline and at follow-up after a median time of 5 years. Polyphenol intake, including four main polyphenol classes and eighteen subclasses, was estimated using validated dietary questionnaires and Phenol-Explorer. Multilevel mixed linear regression models were used to estimate the associations. Results: Participants gained, on average, 2.6 kg (±5.0 kg) over 5 years. Total flavonoids intake was inversely associated with body weight change (−0.195 kg/5 years, 95% CI: −0.262 to −0.128). However, the intake of total polyphenols (0.205 kg/5 years, 95% CI: 0.138 to 0.272) and intake of hydroxycinnamic acids (0.324 kg/5 years, 95% CI: 0.267 to 0.381) were positively associated with body weight gain. In analyses stratified by coffee consumption, hydroxycinnamic acid intake was positively associated with body weight gain in coffee consumers (0.379 kg/5 years, 95% CI: 0.319 to 0.440), but not in coffee nonconsumers (−0.179 kg/5 years, 95% CI: −0.490 to 0.133). Conclusions: Higher intakes of flavonoids and their subclasses are inversely associated with a modest body weight change. Results regarding hydroxycinnamic acids in coffee consumers require further investigation.
U2 - 10.1002/oby.23689
DO - 10.1002/oby.23689
M3 - Journal article
C2 - 36693804
AN - SCOPUS:85144985365
VL - 31
SP - 1146
EP - 1158
JO - Obesity
JF - Obesity
SN - 1930-7381
IS - 4
ER -
ID: 338588434