Result of the project European Committee « Health Alliance for prudent antibiotic prescribing in patients with respiratory tract infections» (HAPPY AUDIT), has showed: the use of method of medical internal audit (APO method) and implementing the Point of Care (POC) tests: Strep A antigen test and C-reactive protein test (CRP) in general practice may lead to a reduction in antibiotic prescribing to patients with RTIs and may lead to decrease of bacterial resistance to antibiotics.