WHO classification 2008 of myeloproliferative neoplasms: a workshop learning effect - the Danish experience
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WHO classification 2008 of myeloproliferative neoplasms : a workshop learning effect - the Danish experience. / Madelung, Ann B; Bondo, Henrik; Stamp, Inger; Løvgreen, Preben; Nielsen, Signe L; Falensteen, Anne; Knudsen, Helle; Svendsen, Kira D; Lange, Theis; Ralfkiaer, Elisabeth; Nielsen, Karsten; Hasselbalch, Hans; Thiele, Jürgen.
I: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Bind 123, Nr. 9, 09.2015, s. 787-92.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - WHO classification 2008 of myeloproliferative neoplasms
T2 - a workshop learning effect - the Danish experience
AU - Madelung, Ann B
AU - Bondo, Henrik
AU - Stamp, Inger
AU - Løvgreen, Preben
AU - Nielsen, Signe L
AU - Falensteen, Anne
AU - Knudsen, Helle
AU - Svendsen, Kira D
AU - Lange, Theis
AU - Ralfkiaer, Elisabeth
AU - Nielsen, Karsten
AU - Hasselbalch, Hans
AU - Thiele, Jürgen
N1 - © 2015 APMIS. Published by John Wiley & Sons Ltd.
PY - 2015/9
Y1 - 2015/9
N2 - We examined the learning effect of a workshop for Danish hematopathologists led by an international expert regarding histological subtyping of myeloproliferative neoplasms (MPN). Six hematopathologists evaluated 43 bone marrow (BM) biopsies according to the WHO description (2008), blinded to clinical data. All panelists then participated in the workshop. The case biopsies - mixed with 251 other MPN BM biopsies - were reviewed again. Consensus regarding the histological subtype was significantly improved; from 49% to 72% (Fleiss kappa value 0.302 pre-workshop, 0.474 post-workshop; p = 0.004). There was no significant effect on the isolated morphological characteristics. Agreement between cases with histological consensus and clinical diagnosis was 86% without significant change during workshop sessions. Our study demonstrates that experienced hematopathologists can significantly improve their diagnostic ability by a workshop led by an international expert; not by improving the evaluation of individual histological parameters but by weighting these in their conclusive diagnosis.
AB - We examined the learning effect of a workshop for Danish hematopathologists led by an international expert regarding histological subtyping of myeloproliferative neoplasms (MPN). Six hematopathologists evaluated 43 bone marrow (BM) biopsies according to the WHO description (2008), blinded to clinical data. All panelists then participated in the workshop. The case biopsies - mixed with 251 other MPN BM biopsies - were reviewed again. Consensus regarding the histological subtype was significantly improved; from 49% to 72% (Fleiss kappa value 0.302 pre-workshop, 0.474 post-workshop; p = 0.004). There was no significant effect on the isolated morphological characteristics. Agreement between cases with histological consensus and clinical diagnosis was 86% without significant change during workshop sessions. Our study demonstrates that experienced hematopathologists can significantly improve their diagnostic ability by a workshop led by an international expert; not by improving the evaluation of individual histological parameters but by weighting these in their conclusive diagnosis.
KW - Adult
KW - Biopsy
KW - Bone Marrow
KW - Bone Marrow Neoplasms
KW - Case-Control Studies
KW - Humans
KW - Myeloproliferative Disorders
KW - World Health Organization
KW - Young Adult
U2 - 10.1111/apm.12417
DO - 10.1111/apm.12417
M3 - Journal article
C2 - 26200697
VL - 123
SP - 787
EP - 792
JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
SN - 0903-4641
IS - 9
ER -
ID: 160498599