Weight loss relapse associated with exposure to perfluoroalkylate substances

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Objective: The purpose of this study was to test the hypothesis that perfluorinated alkylate substance (PFAS) exposures are associated with body weight increases in a dietary intervention study. 

Methods: In the DioGenes trial, adults with obesity first lost at least 8% of their body weight and then completed at least 26 weeks on a specific diet. Concentrations of five major PFASs were assessed in plasma samples from study baseline. 

Results: In 381 participants with complete data, plasma concentrations averaged 2.9 ng/mL and 1.0 ng/mL for perfluorooctanoic acid (PFOA) and perfluorohexanesulfonic acid (PFHxS), respectively. A doubling in plasma PFOA was associated with an increase in weight at 26 weeks by 1.50 kg (95% CI: 0.88–2.11), with an increase of 0.91 kg (95% CI: 0.54–1.27) for PFHxS, independent of diet groups and sex. Associations for other PFASs were in the same direction and significant, although not after adjustment for PFOA and PFHxS. Weight changes associated with elevated PFAS exposures were similar to or larger than average changes ascribed to the different diet groups. 

Conclusions: Elevated plasma concentrations of PFOA and PFHxS were associated with increased weight gain that exceeded those related to the diets. Obesogenic PFASs may cause weight gain and thus contribute to the obesity pandemic.

Udgave nummer6
Sider (fra-til)1686-1696
Antal sider11
StatusUdgivet - 2023

Bibliografisk note

CURIS 2023 NEXS 113

Funding Information:
This work was supported by the Independent Research Fund Denmark (8020‐00039B). Diogenes is the acronym of the project “Diet, Obesity and Genes” supported by the European Commission's Sixth Framework Program (Contract no. FOOD‐CT‐2005‐513946; https://cordis.europa.eu/project/id/513946/reporting ); local sponsors made financial contributions to the shop centers, which also received foods free of charge from manufacturers. Philippe Grandjean is also supported by the National Institute of Environmental Health Sciences (ES027706). The study funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit the manuscript for publication. The authors are solely responsible for all results and conclusions, which do not necessarily reflect the position of any of the funders.

Publisher Copyright:
© 2023 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society.

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