TY - JOUR

T1 - Residential exposure to transportation noise in Denmark and incidence of dementia

T2 - national cohort study

AU - Cantuaria, Manuella Lech

AU - Waldorff, Frans Boch

AU - Wermuth, Lene

AU - Pedersen, Ellen Raben

AU - Poulsen, Aslak Harbo

AU - Thacher, Jesse Daniel

AU - Raaschou-Nielsen, Ole

AU - Ketzel, Matthias

AU - Khan, Jibran

AU - Valencia, Victor H.

AU - Schmidt, Jesper Hvass

AU - Sørensen, Mette

PY - 2021

Y1 - 2021

N2 - OBJECTIVETo investigate the association between long term residential exposure to road traffic and railway noise and risk of incident dementia.DESIGNNationwide prospective register based cohort study.SETTINGDenmark.PARTICIPANTS1 938 994 adults aged >= 60 years living in Denmark between 1 January 2004 and 31 December 2017.MAIN OUTCOME MEASURESIncident cases of all cause dementia and dementia subtypes (Alzheimer's disease, vascular dementia, and Parkinson's disease related dementia), identified from national hospital and prescription registries.RESULTSThe study population included 103 500 participants with incident dementia, and of those, 31 219 received a diagnosis of Alzheimer's disease, 8664 of vascular dementia, and 2192 of Parkinson's disease related dementia. Using Cox regression models, 10 year mean exposure to road traffic and railway noise at the most (L(den)max) and least (L(den)min) exposed facades of buildings were associated with a higher risk of all cause dementia. These associations showed a general pattern of higher hazard ratios with higher noise exposure, but with a levelling off or even small declines in risk at higher noise levels. In subtype analyses, both road traffic noise and railway noise were associated with a higher risk of Alzheimer's disease, with hazard ratios of 1.16 (95% confidence interval 1.11 to 1.22) for road Ldenmax >= 65 dB compared with = 55 dB compared with = 60 dB compared with = 50 dB compared withCONCLUSIONSThis nationwide cohort study found transportation noise to be associated with a higher risk of all cause dementia and dementia subtypes, especially Alzheimer's disease.

AB - OBJECTIVETo investigate the association between long term residential exposure to road traffic and railway noise and risk of incident dementia.DESIGNNationwide prospective register based cohort study.SETTINGDenmark.PARTICIPANTS1 938 994 adults aged >= 60 years living in Denmark between 1 January 2004 and 31 December 2017.MAIN OUTCOME MEASURESIncident cases of all cause dementia and dementia subtypes (Alzheimer's disease, vascular dementia, and Parkinson's disease related dementia), identified from national hospital and prescription registries.RESULTSThe study population included 103 500 participants with incident dementia, and of those, 31 219 received a diagnosis of Alzheimer's disease, 8664 of vascular dementia, and 2192 of Parkinson's disease related dementia. Using Cox regression models, 10 year mean exposure to road traffic and railway noise at the most (L(den)max) and least (L(den)min) exposed facades of buildings were associated with a higher risk of all cause dementia. These associations showed a general pattern of higher hazard ratios with higher noise exposure, but with a levelling off or even small declines in risk at higher noise levels. In subtype analyses, both road traffic noise and railway noise were associated with a higher risk of Alzheimer's disease, with hazard ratios of 1.16 (95% confidence interval 1.11 to 1.22) for road Ldenmax >= 65 dB compared with = 55 dB compared with = 60 dB compared with = 50 dB compared withCONCLUSIONSThis nationwide cohort study found transportation noise to be associated with a higher risk of all cause dementia and dementia subtypes, especially Alzheimer's disease.

KW - AIR-POLLUTION

KW - TRAFFIC NOISE

KW - COGNITIVE IMPAIRMENT

KW - ALCOHOL-CONSUMPTION

KW - ROAD

KW - ANNOYANCE

KW - ASSOCIATION

KW - DISEASE

KW - STRESS

KW - RISK

U2 - 10.1136/bmj.n1954

DO - 10.1136/bmj.n1954

M3 - Journal article

C2 - 34497091

VL - 374

JO - British Medical Journal (Danish Edition)

JF - British Medical Journal (Danish Edition)

SN - 0959-535X

M1 - 1954

ER -