Parental occupational exposure pre- and post-conception and development of asthma in offspring
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Parental occupational exposure pre- and post-conception and development of asthma in offspring. / Pape, Kathrine; Svanes, Cecile; Sejbæk, Camilla S.; Malinovschi, Andrei; Benediktsdottir, Byndis; Forsberg, Bertil; Janson, Christer; Benke, Geza; Tjalvin, Gro; Sánchez-Ramos, José Luis; Zock, Jan Paul; Toren, Kjell; Bråbäck, Lennart; Holm, Mathias; Jõgi, Rain; Bertelsen, Randi J.; Gíslason, Thorarin; Sigsgaard, Torben; Liu, Xiaoqin; Hougaard, Karin S.; Johannessen, Ane; Lodge, Caroline; Dharmage, Shyamali C.; Schlünssen, Vivi.
I: International Journal of Epidemiology, Bind 49, Nr. 6, 2021, s. 1856-1869.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Parental occupational exposure pre- and post-conception and development of asthma in offspring
AU - Pape, Kathrine
AU - Svanes, Cecile
AU - Sejbæk, Camilla S.
AU - Malinovschi, Andrei
AU - Benediktsdottir, Byndis
AU - Forsberg, Bertil
AU - Janson, Christer
AU - Benke, Geza
AU - Tjalvin, Gro
AU - Sánchez-Ramos, José Luis
AU - Zock, Jan Paul
AU - Toren, Kjell
AU - Bråbäck, Lennart
AU - Holm, Mathias
AU - Jõgi, Rain
AU - Bertelsen, Randi J.
AU - Gíslason, Thorarin
AU - Sigsgaard, Torben
AU - Liu, Xiaoqin
AU - Hougaard, Karin S.
AU - Johannessen, Ane
AU - Lodge, Caroline
AU - Dharmage, Shyamali C.
AU - Schlünssen, Vivi
PY - 2021
Y1 - 2021
N2 - BACKGROUND: While direct effects of occupational exposures on an individual's respiratory health are evident, a new paradigm is emerging on the possible effects of pre-conception occupational exposure on respiratory health in offspring. We aimed to study the association between parental occupational exposure starting before conception and asthma in their offspring (at 0-15 years of age). METHODS: We studied 3985 offspring participating in the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) generation study. Their mothers or fathers (n = 2931) previously participated in the European Community Respiratory Health Survey (ECRHS). Information was obtained from questionnaires on parental job history pre- and post-conception which was linked to an asthma-specific job-exposure matrix (JEM). We assessed the association between parental occupational exposure and offspring asthma, applying logistic regression models, clustered by family and adjusted for study centre, offspring sex, parental characteristics (age, asthma onset, place of upbringing, smoking) and grandparents' level of education. RESULTS: Parental occupational exposure to microorganisms, pesticides, allergens or reactive chemicals pre-conception or both pre- and post-conception was not related to offspring asthma; in general, subgroup analyses confirmed this result. However, maternal exposure both pre- and post-conception to allergens and reactive chemicals was associated with increased odds for early-onset asthma in offspring (0-3 years of age); odds ratio 1.70 (95% CI: 1.02-2.84) and 1.65 (95% CI: 0.98-2.77), respectively. CONCLUSIONS: This study did not find evidence that parental occupational exposure, defined by an asthma JEM before conception only or during pre- and post-conception vs non-exposed, was associated with offspring asthma.
AB - BACKGROUND: While direct effects of occupational exposures on an individual's respiratory health are evident, a new paradigm is emerging on the possible effects of pre-conception occupational exposure on respiratory health in offspring. We aimed to study the association between parental occupational exposure starting before conception and asthma in their offspring (at 0-15 years of age). METHODS: We studied 3985 offspring participating in the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) generation study. Their mothers or fathers (n = 2931) previously participated in the European Community Respiratory Health Survey (ECRHS). Information was obtained from questionnaires on parental job history pre- and post-conception which was linked to an asthma-specific job-exposure matrix (JEM). We assessed the association between parental occupational exposure and offspring asthma, applying logistic regression models, clustered by family and adjusted for study centre, offspring sex, parental characteristics (age, asthma onset, place of upbringing, smoking) and grandparents' level of education. RESULTS: Parental occupational exposure to microorganisms, pesticides, allergens or reactive chemicals pre-conception or both pre- and post-conception was not related to offspring asthma; in general, subgroup analyses confirmed this result. However, maternal exposure both pre- and post-conception to allergens and reactive chemicals was associated with increased odds for early-onset asthma in offspring (0-3 years of age); odds ratio 1.70 (95% CI: 1.02-2.84) and 1.65 (95% CI: 0.98-2.77), respectively. CONCLUSIONS: This study did not find evidence that parental occupational exposure, defined by an asthma JEM before conception only or during pre- and post-conception vs non-exposed, was associated with offspring asthma.
KW - job-exposure matrices
KW - air pollutants
KW - asthma
KW - Epidemiology
KW - generation study
KW - occupation
KW - occupational exposure
U2 - 10.1093/ije/dyaa085
DO - 10.1093/ije/dyaa085
M3 - Journal article
C2 - 32666076
AN - SCOPUS:85100359615
VL - 49
SP - 1856
EP - 1869
JO - International Journal of Epidemiology
JF - International Journal of Epidemiology
SN - 0300-5771
IS - 6
ER -
ID: 257595342