Long-term mortality and health-related quality of life of lower versus higher oxygenation targets in ICU patients with severe hypoxaemia
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Long-term mortality and health-related quality of life of lower versus higher oxygenation targets in ICU patients with severe hypoxaemia. / Crescioli, Elena; Klitgaard, Thomas Lass; Poulsen, Lone Musaeus; Brand, Bjørn Anders; Siegemund, Martin; Grøfte, Thorbjørn; Keus, Frederik; Pedersen, Ulf Gøttrup; Bäcklund, Minna; Karttunen, Johanna; Morgan, Matthew; Ciubotariu, Andrei; Bunzel, Anne-Marie Gellert; Vestergaard, Stine Rom; Jensen, Nicolaj Munch; Jensen, Thomas Steen; Kjær, Maj-Brit Nørregaard; Jensen, Aksel Karl Georg; Lange, Theis; Wetterslev, Jørn; Perner, Anders; Schjørring, Olav Lilleholt; Rasmussen, Bodil Steen.
I: Intensive Care Medicine, Bind 48, Nr. 6, 2022, s. 714–722.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Long-term mortality and health-related quality of life of lower versus higher oxygenation targets in ICU patients with severe hypoxaemia
AU - Crescioli, Elena
AU - Klitgaard, Thomas Lass
AU - Poulsen, Lone Musaeus
AU - Brand, Bjørn Anders
AU - Siegemund, Martin
AU - Grøfte, Thorbjørn
AU - Keus, Frederik
AU - Pedersen, Ulf Gøttrup
AU - Bäcklund, Minna
AU - Karttunen, Johanna
AU - Morgan, Matthew
AU - Ciubotariu, Andrei
AU - Bunzel, Anne-Marie Gellert
AU - Vestergaard, Stine Rom
AU - Jensen, Nicolaj Munch
AU - Jensen, Thomas Steen
AU - Kjær, Maj-Brit Nørregaard
AU - Jensen, Aksel Karl Georg
AU - Lange, Theis
AU - Wetterslev, Jørn
AU - Perner, Anders
AU - Schjørring, Olav Lilleholt
AU - Rasmussen, Bodil Steen
N1 - © 2022. Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2022
Y1 - 2022
N2 - PURPOSE: We assessed outcomes after 1 year of lower versus higher oxygenation targets in intensive care unit (ICU) patients with severe hypoxaemia.METHODS: Pre-planned analyses evaluating 1-year mortality and health-related quality-of-life (HRQoL) outcomes in the previously published Handling Oxygenation Targets in the ICU trial which randomised 2928 adults with acute hypoxaemia to targets of arterial oxygen of 8 kPa or 12 kPa throughout the ICU stay up to 90 days. One-year all-cause mortality was assessed in the intention-to-treat population. HRQoL was assessed using EuroQol 5 dimensions 5 levels (EQ-5D-5L) questionnaire and EQ visual analogue scale score (EQ-VAS), and analyses were conducted in both survivors only and the intention-to-treat population with assignment of the worst scores to deceased patients.RESULTS: We obtained 1-year vital status for 2887/2928 (98.6%), and HRQoL for 2600/2928 (88.8%) of the trial population. One year after randomisation, 707/1442 patients (49%) in the lower oxygenation group vs. 704/1445 (48.7%) in the higher oxygenation group had died (adjusted risk ratio 1.00; 95% confidence interval 0.93-1.08, p = 0.92). In total, 1189/1476 (80.4%) 1-year survivors participated in HRQoL interviews: median EQ-VAS scores were 65 (interquartile range 50-80) in the lower oxygenation group versus 67 (50-80) in the higher oxygenation group (p = 0.98). None of the five EQ-5D-5L dimensions differed between groups.CONCLUSION: Among adult ICU patients with severe hypoxaemia, a lower oxygenation target (8 kPa) did not improve survival or HRQoL at 1 year as compared to a higher oxygenation target (12 kPa).
AB - PURPOSE: We assessed outcomes after 1 year of lower versus higher oxygenation targets in intensive care unit (ICU) patients with severe hypoxaemia.METHODS: Pre-planned analyses evaluating 1-year mortality and health-related quality-of-life (HRQoL) outcomes in the previously published Handling Oxygenation Targets in the ICU trial which randomised 2928 adults with acute hypoxaemia to targets of arterial oxygen of 8 kPa or 12 kPa throughout the ICU stay up to 90 days. One-year all-cause mortality was assessed in the intention-to-treat population. HRQoL was assessed using EuroQol 5 dimensions 5 levels (EQ-5D-5L) questionnaire and EQ visual analogue scale score (EQ-VAS), and analyses were conducted in both survivors only and the intention-to-treat population with assignment of the worst scores to deceased patients.RESULTS: We obtained 1-year vital status for 2887/2928 (98.6%), and HRQoL for 2600/2928 (88.8%) of the trial population. One year after randomisation, 707/1442 patients (49%) in the lower oxygenation group vs. 704/1445 (48.7%) in the higher oxygenation group had died (adjusted risk ratio 1.00; 95% confidence interval 0.93-1.08, p = 0.92). In total, 1189/1476 (80.4%) 1-year survivors participated in HRQoL interviews: median EQ-VAS scores were 65 (interquartile range 50-80) in the lower oxygenation group versus 67 (50-80) in the higher oxygenation group (p = 0.98). None of the five EQ-5D-5L dimensions differed between groups.CONCLUSION: Among adult ICU patients with severe hypoxaemia, a lower oxygenation target (8 kPa) did not improve survival or HRQoL at 1 year as compared to a higher oxygenation target (12 kPa).
U2 - 10.1007/s00134-022-06695-0
DO - 10.1007/s00134-022-06695-0
M3 - Journal article
C2 - 35441849
VL - 48
SP - 714
EP - 722
JO - European Journal of Intensive Care Medicine
JF - European Journal of Intensive Care Medicine
SN - 0935-1701
IS - 6
ER -
ID: 304570098