Life-course socio-economic position, area deprivation and Type 2 diabetes: findings from the British Women's Heart and Health Study
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Life-course socio-economic position, area deprivation and Type 2 diabetes: findings from the British Women's Heart and Health Study. / Andersen, A F; Carson, C; Watt, H C; Lawlor, D A; Avlund, K; Ebrahim, S.
I: Diabetic Medicine, Bind 25, Nr. 12, 2008, s. 1462-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Life-course socio-economic position, area deprivation and Type 2 diabetes: findings from the British Women's Heart and Health Study
AU - Andersen, A F
AU - Carson, C
AU - Watt, H C
AU - Lawlor, D A
AU - Avlund, K
AU - Ebrahim, S
PY - 2008
Y1 - 2008
N2 - Objectives We examined whether area deprivation influenced risk of Type 2 diabetes, fasting blood glucose and insulin resistance over and above the effect of individual socio-economic position (SEP) measured across the life course. Methods A cross-sectional analysis of 4286 women aged 60 to 79 years from 457 British electoral wards in 23 towns. Results Area deprivation was positively associated with diagnosed [odds ratio (OR) 1.32, 95% confidence interval (CI) 1.13, 1.53, per quintile of area deprivation, n = 2895], but not undiagnosed Type 2 diabetes after adjustment for individual life-course SEP. This association was robust to adjustment for adult health behaviours and physiological risk factors. Insulin resistance [homeostasis model assessment (HOMA) score] increased by 1.90% (95% CI 0.01, 3.82, n = 2526) per quintile of area deprivation after adjustment for individual SEP, while fasting blood glucose increased by 0.69% (95% CI 0.16, 1.22, n = 2875) after adjustment for individual SEP. Conclusions Area level deprivation independently influences diagnosed Type 2 diabetes, insulin resistance and fasting blood glucose. Examination of more specific characteristics of places is needed to understand the mechanisms by which these effects arise.
AB - Objectives We examined whether area deprivation influenced risk of Type 2 diabetes, fasting blood glucose and insulin resistance over and above the effect of individual socio-economic position (SEP) measured across the life course. Methods A cross-sectional analysis of 4286 women aged 60 to 79 years from 457 British electoral wards in 23 towns. Results Area deprivation was positively associated with diagnosed [odds ratio (OR) 1.32, 95% confidence interval (CI) 1.13, 1.53, per quintile of area deprivation, n = 2895], but not undiagnosed Type 2 diabetes after adjustment for individual life-course SEP. This association was robust to adjustment for adult health behaviours and physiological risk factors. Insulin resistance [homeostasis model assessment (HOMA) score] increased by 1.90% (95% CI 0.01, 3.82, n = 2526) per quintile of area deprivation after adjustment for individual SEP, while fasting blood glucose increased by 0.69% (95% CI 0.16, 1.22, n = 2875) after adjustment for individual SEP. Conclusions Area level deprivation independently influences diagnosed Type 2 diabetes, insulin resistance and fasting blood glucose. Examination of more specific characteristics of places is needed to understand the mechanisms by which these effects arise.
U2 - 10.1111/j.1464-5491.2008.02594.x
DO - 10.1111/j.1464-5491.2008.02594.x
M3 - Journal article
C2 - 19046246
VL - 25
SP - 1462
EP - 1468
JO - Diabetic Medicine
JF - Diabetic Medicine
SN - 0742-3071
IS - 12
ER -
ID: 8878021