Health outcomes associated with lung function decline and respiratory symptoms and disease in a community cohort

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Health outcomes associated with lung function decline and respiratory symptoms and disease in a community cohort. / Baughman, Penelope; Marott, Jacob L; Lange, Peter; Andrew, Michael; Hnizdo, Eva.

I: C O P D, Bind 8, Nr. 2, 04.2011, s. 103-13.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Baughman, P, Marott, JL, Lange, P, Andrew, M & Hnizdo, E 2011, 'Health outcomes associated with lung function decline and respiratory symptoms and disease in a community cohort', C O P D, bind 8, nr. 2, s. 103-13. https://doi.org/10.3109/15412555.2011.558544

APA

Baughman, P., Marott, J. L., Lange, P., Andrew, M., & Hnizdo, E. (2011). Health outcomes associated with lung function decline and respiratory symptoms and disease in a community cohort. C O P D, 8(2), 103-13. https://doi.org/10.3109/15412555.2011.558544

Vancouver

Baughman P, Marott JL, Lange P, Andrew M, Hnizdo E. Health outcomes associated with lung function decline and respiratory symptoms and disease in a community cohort. C O P D. 2011 apr.;8(2):103-13. https://doi.org/10.3109/15412555.2011.558544

Author

Baughman, Penelope ; Marott, Jacob L ; Lange, Peter ; Andrew, Michael ; Hnizdo, Eva. / Health outcomes associated with lung function decline and respiratory symptoms and disease in a community cohort. I: C O P D. 2011 ; Bind 8, Nr. 2. s. 103-13.

Bibtex

@article{24ca5c1e02f6483791391d090d1edb73,
title = "Health outcomes associated with lung function decline and respiratory symptoms and disease in a community cohort",
abstract = "BACKGROUND: In workplace respiratory disease prevention, a thorough understanding is needed of the relative contributions of lung function loss and respiratory symptoms in predicting adverse health outcomes.METHODS: Copenhagen City Heart Study respiratory data collected at 4 examinations (1976-2003) and morbidity and mortality data were used to investigate these relationships. With 15 or more years of follow-up for a hospital diagnosis of chronic obstructive pulmonary disease (COPD) morbidity, COPD or coronary heart disease (CHD) mortality, and all-cause mortality, risks for these outcomes were estimated in relation to asthma, chronic bronchitis, shortness of breath, and lung function level at examination 2 (1981-1983) or lung function decline established from examinations 1 (1976-1978) to 2 using 4 measures (FEV(1) slope, FEV(1) relative slope, American College of Occupational and Environmental Medicine's Longitudinal Normal Limit [LNL], or a limit of 90 milliliters per year [ml/yr]). These risks were estimated by hazard ratios (HR) and 95% confidence intervals (CI) adjusted for age, height-adjusted baseline forced expiratory volume in 1 second (FEV(1)/height(2)), and height.RESULTS: For COPD morbidity, the increasing trend in the HR (95% CI) by quartiles of the FEV(1) slope reached a maximum of 3.77 (2.76-5.15) for males, 6.12 (4.63-8.10) for females, and 4.14 (1.57-10.90) for never-smokers. Significant increasing trends were also observed for mortality, with females at higher risk.CONCLUSION: Lung function decline was associated with increased risk of COPD morbidity and mortality emphasizing the need to monitor lung function change over time in at-risk occupational populations.",
keywords = "Adult, Aged, Cohort Studies, Coronary Disease, Female, Forced Expiratory Volume, Humans, Lung, Male, Middle Aged, Morbidity, Proportional Hazards Models, Pulmonary Disease, Chronic Obstructive, Risk Factors",
author = "Penelope Baughman and Marott, {Jacob L} and Peter Lange and Michael Andrew and Eva Hnizdo",
year = "2011",
month = apr,
doi = "10.3109/15412555.2011.558544",
language = "English",
volume = "8",
pages = "103--13",
journal = "C O P D",
issn = "1541-2555",
publisher = "Taylor & Francis",
number = "2",

}

RIS

TY - JOUR

T1 - Health outcomes associated with lung function decline and respiratory symptoms and disease in a community cohort

AU - Baughman, Penelope

AU - Marott, Jacob L

AU - Lange, Peter

AU - Andrew, Michael

AU - Hnizdo, Eva

PY - 2011/4

Y1 - 2011/4

N2 - BACKGROUND: In workplace respiratory disease prevention, a thorough understanding is needed of the relative contributions of lung function loss and respiratory symptoms in predicting adverse health outcomes.METHODS: Copenhagen City Heart Study respiratory data collected at 4 examinations (1976-2003) and morbidity and mortality data were used to investigate these relationships. With 15 or more years of follow-up for a hospital diagnosis of chronic obstructive pulmonary disease (COPD) morbidity, COPD or coronary heart disease (CHD) mortality, and all-cause mortality, risks for these outcomes were estimated in relation to asthma, chronic bronchitis, shortness of breath, and lung function level at examination 2 (1981-1983) or lung function decline established from examinations 1 (1976-1978) to 2 using 4 measures (FEV(1) slope, FEV(1) relative slope, American College of Occupational and Environmental Medicine's Longitudinal Normal Limit [LNL], or a limit of 90 milliliters per year [ml/yr]). These risks were estimated by hazard ratios (HR) and 95% confidence intervals (CI) adjusted for age, height-adjusted baseline forced expiratory volume in 1 second (FEV(1)/height(2)), and height.RESULTS: For COPD morbidity, the increasing trend in the HR (95% CI) by quartiles of the FEV(1) slope reached a maximum of 3.77 (2.76-5.15) for males, 6.12 (4.63-8.10) for females, and 4.14 (1.57-10.90) for never-smokers. Significant increasing trends were also observed for mortality, with females at higher risk.CONCLUSION: Lung function decline was associated with increased risk of COPD morbidity and mortality emphasizing the need to monitor lung function change over time in at-risk occupational populations.

AB - BACKGROUND: In workplace respiratory disease prevention, a thorough understanding is needed of the relative contributions of lung function loss and respiratory symptoms in predicting adverse health outcomes.METHODS: Copenhagen City Heart Study respiratory data collected at 4 examinations (1976-2003) and morbidity and mortality data were used to investigate these relationships. With 15 or more years of follow-up for a hospital diagnosis of chronic obstructive pulmonary disease (COPD) morbidity, COPD or coronary heart disease (CHD) mortality, and all-cause mortality, risks for these outcomes were estimated in relation to asthma, chronic bronchitis, shortness of breath, and lung function level at examination 2 (1981-1983) or lung function decline established from examinations 1 (1976-1978) to 2 using 4 measures (FEV(1) slope, FEV(1) relative slope, American College of Occupational and Environmental Medicine's Longitudinal Normal Limit [LNL], or a limit of 90 milliliters per year [ml/yr]). These risks were estimated by hazard ratios (HR) and 95% confidence intervals (CI) adjusted for age, height-adjusted baseline forced expiratory volume in 1 second (FEV(1)/height(2)), and height.RESULTS: For COPD morbidity, the increasing trend in the HR (95% CI) by quartiles of the FEV(1) slope reached a maximum of 3.77 (2.76-5.15) for males, 6.12 (4.63-8.10) for females, and 4.14 (1.57-10.90) for never-smokers. Significant increasing trends were also observed for mortality, with females at higher risk.CONCLUSION: Lung function decline was associated with increased risk of COPD morbidity and mortality emphasizing the need to monitor lung function change over time in at-risk occupational populations.

KW - Adult

KW - Aged

KW - Cohort Studies

KW - Coronary Disease

KW - Female

KW - Forced Expiratory Volume

KW - Humans

KW - Lung

KW - Male

KW - Middle Aged

KW - Morbidity

KW - Proportional Hazards Models

KW - Pulmonary Disease, Chronic Obstructive

KW - Risk Factors

U2 - 10.3109/15412555.2011.558544

DO - 10.3109/15412555.2011.558544

M3 - Journal article

C2 - 21495838

VL - 8

SP - 103

EP - 113

JO - C O P D

JF - C O P D

SN - 1541-2555

IS - 2

ER -

ID: 161393221