Decreasing TSH levels in patients with Seasonal Affective Disorder (SAD) responding to 1 week of bright light therapy
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Decreasing TSH levels in patients with Seasonal Affective Disorder (SAD) responding to 1 week of bright light therapy. / Martiny, Klaus; Simonsen, Christian; Lunde, Marianne; Clemmensen, Lars; Bech, Per.
I: Journal of Affective Disorders, Bind 79, Nr. 1-3, 01.04.2004, s. 253-257.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Decreasing TSH levels in patients with Seasonal Affective Disorder (SAD) responding to 1 week of bright light therapy
AU - Martiny, Klaus
AU - Simonsen, Christian
AU - Lunde, Marianne
AU - Clemmensen, Lars
AU - Bech, Per
PY - 2004/4/1
Y1 - 2004/4/1
N2 - Background: Seasonal Affective Disorder (SAD) is characterised by lowered mood and atypical depressive symptoms such as hypersomnia, weight gain and fatigue. These symptoms seem associated with hypothyroidism, but the results of evaluations of the thyroid function in SAD patients have been conflicting, most likely due to the very small number of observations. Methods: In total, 83 patients fulfilling the DSM-III-R criteria for SAD were treated with bright light for 1 week in an open trial. Thyroid function was evaluated by TSH (thyroid-stimulating hormone), T4 (thyroxine) and T3 (triiodthyronine) levels at baseline and after 1 week of bright light treatment. Results: The response rate in terms of a 50% reduction of pre-treatment scores on the Hamilton Depressions Rating Scale (HAM-D17) was 61%. The TSH levels in all 83 patients decreased significantly from 1.57 at baseline to 1.30 at endpoint. In the group of responders (n=52) the TSH levels decreased significantly from 1.71 to 1.37, while in the group of non-responders (n=31) the decrease in TSH levels was not statistically significant. Conclusion: During 1 week of bright light therapy the TSH levels in SAD patients were reduced, with the highest reduction in the group of patients responding to light therapy.
AB - Background: Seasonal Affective Disorder (SAD) is characterised by lowered mood and atypical depressive symptoms such as hypersomnia, weight gain and fatigue. These symptoms seem associated with hypothyroidism, but the results of evaluations of the thyroid function in SAD patients have been conflicting, most likely due to the very small number of observations. Methods: In total, 83 patients fulfilling the DSM-III-R criteria for SAD were treated with bright light for 1 week in an open trial. Thyroid function was evaluated by TSH (thyroid-stimulating hormone), T4 (thyroxine) and T3 (triiodthyronine) levels at baseline and after 1 week of bright light treatment. Results: The response rate in terms of a 50% reduction of pre-treatment scores on the Hamilton Depressions Rating Scale (HAM-D17) was 61%. The TSH levels in all 83 patients decreased significantly from 1.57 at baseline to 1.30 at endpoint. In the group of responders (n=52) the TSH levels decreased significantly from 1.71 to 1.37, while in the group of non-responders (n=31) the decrease in TSH levels was not statistically significant. Conclusion: During 1 week of bright light therapy the TSH levels in SAD patients were reduced, with the highest reduction in the group of patients responding to light therapy.
KW - Atypical depression
KW - Seasonal Affective Disorder
KW - Thyroid-stimulating hormone
KW - TSH
U2 - 10.1016/S0165-0327(02)00361-0
DO - 10.1016/S0165-0327(02)00361-0
M3 - Journal article
C2 - 15023503
AN - SCOPUS:1542404711
VL - 79
SP - 253
EP - 257
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
IS - 1-3
ER -
ID: 209243974