Associations between saliva alpha-amylase, heart rate variability, saliva cortisol and cognitive performance in individuals at ultra high-risk for psychosis
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Associations between saliva alpha-amylase, heart rate variability, saliva cortisol and cognitive performance in individuals at ultra high-risk for psychosis. / Almstrup, Frederik Beske; Nordentoft, Merete; Jensen, Marie Aarrebo; Kristiansen, Jesper; Kristensen, Tina Dam; Wenneberg, Christina; Garde, Anne Helene; Glenth, Louise Birkedal; Nordholm, Dorte.
I: Schizophrenia Research, Bind 255, 2023, s. 165-172.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Associations between saliva alpha-amylase, heart rate variability, saliva cortisol and cognitive performance in individuals at ultra high-risk for psychosis
AU - Almstrup, Frederik Beske
AU - Nordentoft, Merete
AU - Jensen, Marie Aarrebo
AU - Kristiansen, Jesper
AU - Kristensen, Tina Dam
AU - Wenneberg, Christina
AU - Garde, Anne Helene
AU - Glenth, Louise Birkedal
AU - Nordholm, Dorte
PY - 2023
Y1 - 2023
N2 - Background: Cognitive impairments are present in individuals at ultra-high risk (UHR) of psychosis and UHR individuals exhibit a hyperactive and dysfunctional HPA-axis. Increasing stress levels could potentially lead to cognitive impairments and no previous studies have examined the association between physiological stress biomarkers and cognition in UHR individuals. This study aims to examine the association between saliva alpha amylase (SAA), heart rate variability (HRV), saliva cortisol, and cognition in UHR individuals.Method: We included 72 UHR individuals, aged 18-40, fulfilling criteria of the comprehensive assessment of at -risk mental state (CAARMS). Cognitive tests indexed the 7 core domains as stated by Measurement and Treat-ment Research to Improve Cognition in Schizophrenia (MATRICS). Physiological stress levels were observed for one day: saliva was collected at awakening, 30 min and 60 min after awakening and at bedtime. HRV was measured during sleep and before awakening. We used generalized linear model and controlled for multiple testing using false discovery rate (FDR). Results: Higher levels of SAA were significantly associated with lower cognitive performance in the domains of verbal and visual learning and memory, sustained attention, working memory and global neurocognition looking at unadjusted data. Controlling for FDR visual memory, sustained attention and global neurocognition remained significant associated with SAA. We discovered no associations between cortisol and cognition.Conclusion: Visual learning and memory, sustained attention and global neurocognition remained significantly associated with SAA. This finding supports our hypothesis that an association between abnormal stress bio-markers and impaired cognition might be present in UHR individuals.
AB - Background: Cognitive impairments are present in individuals at ultra-high risk (UHR) of psychosis and UHR individuals exhibit a hyperactive and dysfunctional HPA-axis. Increasing stress levels could potentially lead to cognitive impairments and no previous studies have examined the association between physiological stress biomarkers and cognition in UHR individuals. This study aims to examine the association between saliva alpha amylase (SAA), heart rate variability (HRV), saliva cortisol, and cognition in UHR individuals.Method: We included 72 UHR individuals, aged 18-40, fulfilling criteria of the comprehensive assessment of at -risk mental state (CAARMS). Cognitive tests indexed the 7 core domains as stated by Measurement and Treat-ment Research to Improve Cognition in Schizophrenia (MATRICS). Physiological stress levels were observed for one day: saliva was collected at awakening, 30 min and 60 min after awakening and at bedtime. HRV was measured during sleep and before awakening. We used generalized linear model and controlled for multiple testing using false discovery rate (FDR). Results: Higher levels of SAA were significantly associated with lower cognitive performance in the domains of verbal and visual learning and memory, sustained attention, working memory and global neurocognition looking at unadjusted data. Controlling for FDR visual memory, sustained attention and global neurocognition remained significant associated with SAA. We discovered no associations between cortisol and cognition.Conclusion: Visual learning and memory, sustained attention and global neurocognition remained significantly associated with SAA. This finding supports our hypothesis that an association between abnormal stress bio-markers and impaired cognition might be present in UHR individuals.
KW - Ultra High -Risk
KW - Cognition
KW - Stress
KW - Saliva -alpha -amylase
KW - Heart -rate -variability
KW - Cortisol
KW - AUTONOMIC NERVOUS-SYSTEM
KW - CLINICAL HIGH-RISK
KW - AWAKENING RESPONSE
KW - MEMORY RETRIEVAL
KW - MAJOR DEPRESSION
KW - HPA-AXIS
KW - STRESS
KW - SCHIZOPHRENIA
KW - RELIABILITY
KW - CONVERSION
U2 - 10.1016/j.schres.2023.03.041
DO - 10.1016/j.schres.2023.03.041
M3 - Journal article
C2 - 37001391
VL - 255
SP - 165
EP - 172
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
ER -
ID: 346199441