Whole-grain intake in mid-life and healthy ageing in the Danish Diet, Cancer and Health cohort
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Whole-grain intake in mid-life and healthy ageing in the Danish Diet, Cancer and Health cohort. / Eriksen, Anne Kirstine; Grand, Mia Klinten; Kyrø, Cecilie; Wohlfahrt, Jan; Overvad, Kim; Tjønneland, Anne; Olsen, Anja.
I: European Journal of Nutrition, 2024.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Whole-grain intake in mid-life and healthy ageing in the Danish Diet, Cancer and Health cohort
AU - Eriksen, Anne Kirstine
AU - Grand, Mia Klinten
AU - Kyrø, Cecilie
AU - Wohlfahrt, Jan
AU - Overvad, Kim
AU - Tjønneland, Anne
AU - Olsen, Anja
N1 - © 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
PY - 2024
Y1 - 2024
N2 - PURPOSE: Growing elderly populations worldwide have sparked interest in factors promoting healthy aging. Diet and other lifestyle patterns are key factors for healthy ageing; however, evidence is sparse for specific dietary guidelines that are easily implemented in everyday life. Whole grains constitute specific dietary components with unexplored potential in healthy ageing.METHODS: We applied an illness-death multistate model to assess the association between whole-grain intake and life expectancy, both with and without disease, over a 20-year period. Healthy ageing was defined as absence of cancer, ischemic heart disease, stroke, type 2 diabetes, asthma, chronic obstructive pulmonary disease, and dementia during follow-up.RESULTS: Based on information from 22,606 men and 25,468 women in the Danish Diet, Cancer and Health cohort, followed for an average of 13.8 and 17.5 years, respectively, a doubling in whole-grain intake was associated with 0.43 (95% CI: 0.33-0.52) and 0.15 (0.06-0.24) additional years without disease for men and women, respectively. Comparing the highest and lowest quartiles of whole-grain intake, with a special emphasis on men, we found that those with the highest intake lived, on average, one year longer without disease compared to those with the lowest intake. Additionally, although a high intake of whole grains yielded longer life expectancy, the duration of living with disease was shorter.CONCLUSION: Intake of whole grains in mid-life was associated with healthy ageing looking 20 years ahead.
AB - PURPOSE: Growing elderly populations worldwide have sparked interest in factors promoting healthy aging. Diet and other lifestyle patterns are key factors for healthy ageing; however, evidence is sparse for specific dietary guidelines that are easily implemented in everyday life. Whole grains constitute specific dietary components with unexplored potential in healthy ageing.METHODS: We applied an illness-death multistate model to assess the association between whole-grain intake and life expectancy, both with and without disease, over a 20-year period. Healthy ageing was defined as absence of cancer, ischemic heart disease, stroke, type 2 diabetes, asthma, chronic obstructive pulmonary disease, and dementia during follow-up.RESULTS: Based on information from 22,606 men and 25,468 women in the Danish Diet, Cancer and Health cohort, followed for an average of 13.8 and 17.5 years, respectively, a doubling in whole-grain intake was associated with 0.43 (95% CI: 0.33-0.52) and 0.15 (0.06-0.24) additional years without disease for men and women, respectively. Comparing the highest and lowest quartiles of whole-grain intake, with a special emphasis on men, we found that those with the highest intake lived, on average, one year longer without disease compared to those with the lowest intake. Additionally, although a high intake of whole grains yielded longer life expectancy, the duration of living with disease was shorter.CONCLUSION: Intake of whole grains in mid-life was associated with healthy ageing looking 20 years ahead.
U2 - 10.1007/s00394-024-03357-3
DO - 10.1007/s00394-024-03357-3
M3 - Journal article
C2 - 38451283
JO - European Journal of Nutrition
JF - European Journal of Nutrition
SN - 1436-6207
ER -
ID: 387021570