Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

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Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study. / Bellinge, Jamie W.; Dalgaard, Frederik; Murray, Kevin; Connolly, Emma; Blekkenhorst, Lauren C.; Bondonno, Catherine P.; Lewis, Joshua R.; Sim, Marc; Croft, Kevin D.; Gislason, Gunnar; Torp-Pedersen, Christian; Tjønneland, Anne; Overvad, Kim; Hodgson, Jonathan M.; Schultz, Carl; Bondonno, Nicola P.

I: Journal of the American Heart Association, Bind 10, Nr. 16, 020551, 2021.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Bellinge, JW, Dalgaard, F, Murray, K, Connolly, E, Blekkenhorst, LC, Bondonno, CP, Lewis, JR, Sim, M, Croft, KD, Gislason, G, Torp-Pedersen, C, Tjønneland, A, Overvad, K, Hodgson, JM, Schultz, C & Bondonno, NP 2021, 'Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study', Journal of the American Heart Association, bind 10, nr. 16, 020551. https://doi.org/10.1161/JAHA.120.020551

APA

Bellinge, J. W., Dalgaard, F., Murray, K., Connolly, E., Blekkenhorst, L. C., Bondonno, C. P., Lewis, J. R., Sim, M., Croft, K. D., Gislason, G., Torp-Pedersen, C., Tjønneland, A., Overvad, K., Hodgson, J. M., Schultz, C., & Bondonno, N. P. (2021). Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study. Journal of the American Heart Association, 10(16), [020551]. https://doi.org/10.1161/JAHA.120.020551

Vancouver

Bellinge JW, Dalgaard F, Murray K, Connolly E, Blekkenhorst LC, Bondonno CP o.a. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study. Journal of the American Heart Association. 2021;10(16). 020551. https://doi.org/10.1161/JAHA.120.020551

Author

Bellinge, Jamie W. ; Dalgaard, Frederik ; Murray, Kevin ; Connolly, Emma ; Blekkenhorst, Lauren C. ; Bondonno, Catherine P. ; Lewis, Joshua R. ; Sim, Marc ; Croft, Kevin D. ; Gislason, Gunnar ; Torp-Pedersen, Christian ; Tjønneland, Anne ; Overvad, Kim ; Hodgson, Jonathan M. ; Schultz, Carl ; Bondonno, Nicola P. / Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study. I: Journal of the American Heart Association. 2021 ; Bind 10, Nr. 16.

Bibtex

@article{e71ec348ff7d49199f990bfdc316d956,
title = "Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study",
abstract = "Background Dietary vitamin K (K-1 and K-2) may reduce atherosclerotic cardiovascular disease (ASCVD) risk via several mechanisms. However, studies linking vitamin K intake with incident ASCVD are limited. We aimed to determine the relationship between dietary vitamin K intake and ASCVD hospitalizations. Methods and Results In this prospective cohort study, participants from the Danish Diet, Cancer, and Health Study, with no prior ASCVD, completed a food-frequency questionnaire at baseline and were followed up for hospital admissions of ASCVD; ischemic heart disease, ischemic stroke, or peripheral artery disease. Intakes of vitamin K-1 and vitamin K-2 were estimated from the food-frequency questionnaire, and their relationship with ASCVD hospitalizations was determined using Cox proportional hazards models. Among 53 372 Danish citizens with a median (interquartile range) age of 56 (52-60) years, 8726 individuals were hospitalized for any ASCVD during 21 (17-22) years of follow-up. Compared with participants with the lowest vitamin K-1 intakes, participants with the highest intakes had a 21% lower risk of an ASCVD-related hospitalization (hazard ratio, 0.79; 95% CI: 0.74-0.84), after multivariable adjustments for relevant demographic covariates. Likewise for vitamin K-2, the risk of an ASCVD-related hospitalization for participants with the highest intakes was 14% lower than participants with the lowest vitamin K-2 intake (hazard ratio, 0.86; 95% CI, 0.81-0.91). Conclusions Risk of ASCVD was inversely associated with diets high in vitamin K-1 or K-2. The similar inverse associations with both vitamin K-1 and K-2, despite very different dietary sources, highlight the potential importance of vitamin K for ASCVD prevention.",
keywords = "atherosclerotic cardiovascular disease, dietary vitamin K, phylloquinone, menaquinone, primary prevention, prospective cohort study, CORONARY-HEART-DISEASE, MATRIX GLA PROTEIN, FOOD FREQUENCY QUESTIONNAIRE, PHYLLOQUINONE INTAKE, ARTERY CALCIUM, OLDER MEN, RISK, SUPPLEMENTATION, MENAQUINONES, DIAGNOSES",
author = "Bellinge, {Jamie W.} and Frederik Dalgaard and Kevin Murray and Emma Connolly and Blekkenhorst, {Lauren C.} and Bondonno, {Catherine P.} and Lewis, {Joshua R.} and Marc Sim and Croft, {Kevin D.} and Gunnar Gislason and Christian Torp-Pedersen and Anne Tj{\o}nneland and Kim Overvad and Hodgson, {Jonathan M.} and Carl Schultz and Bondonno, {Nicola P.}",
year = "2021",
doi = "10.1161/JAHA.120.020551",
language = "English",
volume = "10",
journal = "Journal of the American Heart Association",
issn = "2047-9980",
publisher = "Wiley-Blackwell",
number = "16",

}

RIS

TY - JOUR

T1 - Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study

AU - Bellinge, Jamie W.

AU - Dalgaard, Frederik

AU - Murray, Kevin

AU - Connolly, Emma

AU - Blekkenhorst, Lauren C.

AU - Bondonno, Catherine P.

AU - Lewis, Joshua R.

AU - Sim, Marc

AU - Croft, Kevin D.

AU - Gislason, Gunnar

AU - Torp-Pedersen, Christian

AU - Tjønneland, Anne

AU - Overvad, Kim

AU - Hodgson, Jonathan M.

AU - Schultz, Carl

AU - Bondonno, Nicola P.

PY - 2021

Y1 - 2021

N2 - Background Dietary vitamin K (K-1 and K-2) may reduce atherosclerotic cardiovascular disease (ASCVD) risk via several mechanisms. However, studies linking vitamin K intake with incident ASCVD are limited. We aimed to determine the relationship between dietary vitamin K intake and ASCVD hospitalizations. Methods and Results In this prospective cohort study, participants from the Danish Diet, Cancer, and Health Study, with no prior ASCVD, completed a food-frequency questionnaire at baseline and were followed up for hospital admissions of ASCVD; ischemic heart disease, ischemic stroke, or peripheral artery disease. Intakes of vitamin K-1 and vitamin K-2 were estimated from the food-frequency questionnaire, and their relationship with ASCVD hospitalizations was determined using Cox proportional hazards models. Among 53 372 Danish citizens with a median (interquartile range) age of 56 (52-60) years, 8726 individuals were hospitalized for any ASCVD during 21 (17-22) years of follow-up. Compared with participants with the lowest vitamin K-1 intakes, participants with the highest intakes had a 21% lower risk of an ASCVD-related hospitalization (hazard ratio, 0.79; 95% CI: 0.74-0.84), after multivariable adjustments for relevant demographic covariates. Likewise for vitamin K-2, the risk of an ASCVD-related hospitalization for participants with the highest intakes was 14% lower than participants with the lowest vitamin K-2 intake (hazard ratio, 0.86; 95% CI, 0.81-0.91). Conclusions Risk of ASCVD was inversely associated with diets high in vitamin K-1 or K-2. The similar inverse associations with both vitamin K-1 and K-2, despite very different dietary sources, highlight the potential importance of vitamin K for ASCVD prevention.

AB - Background Dietary vitamin K (K-1 and K-2) may reduce atherosclerotic cardiovascular disease (ASCVD) risk via several mechanisms. However, studies linking vitamin K intake with incident ASCVD are limited. We aimed to determine the relationship between dietary vitamin K intake and ASCVD hospitalizations. Methods and Results In this prospective cohort study, participants from the Danish Diet, Cancer, and Health Study, with no prior ASCVD, completed a food-frequency questionnaire at baseline and were followed up for hospital admissions of ASCVD; ischemic heart disease, ischemic stroke, or peripheral artery disease. Intakes of vitamin K-1 and vitamin K-2 were estimated from the food-frequency questionnaire, and their relationship with ASCVD hospitalizations was determined using Cox proportional hazards models. Among 53 372 Danish citizens with a median (interquartile range) age of 56 (52-60) years, 8726 individuals were hospitalized for any ASCVD during 21 (17-22) years of follow-up. Compared with participants with the lowest vitamin K-1 intakes, participants with the highest intakes had a 21% lower risk of an ASCVD-related hospitalization (hazard ratio, 0.79; 95% CI: 0.74-0.84), after multivariable adjustments for relevant demographic covariates. Likewise for vitamin K-2, the risk of an ASCVD-related hospitalization for participants with the highest intakes was 14% lower than participants with the lowest vitamin K-2 intake (hazard ratio, 0.86; 95% CI, 0.81-0.91). Conclusions Risk of ASCVD was inversely associated with diets high in vitamin K-1 or K-2. The similar inverse associations with both vitamin K-1 and K-2, despite very different dietary sources, highlight the potential importance of vitamin K for ASCVD prevention.

KW - atherosclerotic cardiovascular disease

KW - dietary vitamin K

KW - phylloquinone

KW - menaquinone

KW - primary prevention

KW - prospective cohort study

KW - CORONARY-HEART-DISEASE

KW - MATRIX GLA PROTEIN

KW - FOOD FREQUENCY QUESTIONNAIRE

KW - PHYLLOQUINONE INTAKE

KW - ARTERY CALCIUM

KW - OLDER MEN

KW - RISK

KW - SUPPLEMENTATION

KW - MENAQUINONES

KW - DIAGNOSES

U2 - 10.1161/JAHA.120.020551

DO - 10.1161/JAHA.120.020551

M3 - Journal article

C2 - 34369182

VL - 10

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

SN - 2047-9980

IS - 16

M1 - 020551

ER -

ID: 276944782