Nitrate in Maternal Drinking Water during Pregnancy and Measures of Male Fecundity in Adult Sons

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Nitrate in Maternal Drinking Water during Pregnancy and Measures of Male Fecundity in Adult Sons. / Clemmensen, Pernille Jul; Brix, Nis; Schullehner, Jorg; Gaml-Sorensen, Anne; Toft, Gunnar; Tøttenborg, Sandra Søgaard; Ebdrup, Ninna Hinchely; Hougaard, Karin Sorig; Hansen, Birgitte; Sigsgaard, Torben; Kolstad, Henrik Albert; Bonde, Jens Peter Ellekilde; Ramlau-Hansen, Cecilia Host.

I: International Journal of Environmental Research and Public Health, Bind 19, Nr. 21, 14428, 2022.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Clemmensen, PJ, Brix, N, Schullehner, J, Gaml-Sorensen, A, Toft, G, Tøttenborg, SS, Ebdrup, NH, Hougaard, KS, Hansen, B, Sigsgaard, T, Kolstad, HA, Bonde, JPE & Ramlau-Hansen, CH 2022, 'Nitrate in Maternal Drinking Water during Pregnancy and Measures of Male Fecundity in Adult Sons', International Journal of Environmental Research and Public Health, bind 19, nr. 21, 14428. https://doi.org/10.3390/ijerph192114428

APA

Clemmensen, P. J., Brix, N., Schullehner, J., Gaml-Sorensen, A., Toft, G., Tøttenborg, S. S., Ebdrup, N. H., Hougaard, K. S., Hansen, B., Sigsgaard, T., Kolstad, H. A., Bonde, J. P. E., & Ramlau-Hansen, C. H. (2022). Nitrate in Maternal Drinking Water during Pregnancy and Measures of Male Fecundity in Adult Sons. International Journal of Environmental Research and Public Health, 19(21), [14428]. https://doi.org/10.3390/ijerph192114428

Vancouver

Clemmensen PJ, Brix N, Schullehner J, Gaml-Sorensen A, Toft G, Tøttenborg SS o.a. Nitrate in Maternal Drinking Water during Pregnancy and Measures of Male Fecundity in Adult Sons. International Journal of Environmental Research and Public Health. 2022;19(21). 14428. https://doi.org/10.3390/ijerph192114428

Author

Clemmensen, Pernille Jul ; Brix, Nis ; Schullehner, Jorg ; Gaml-Sorensen, Anne ; Toft, Gunnar ; Tøttenborg, Sandra Søgaard ; Ebdrup, Ninna Hinchely ; Hougaard, Karin Sorig ; Hansen, Birgitte ; Sigsgaard, Torben ; Kolstad, Henrik Albert ; Bonde, Jens Peter Ellekilde ; Ramlau-Hansen, Cecilia Host. / Nitrate in Maternal Drinking Water during Pregnancy and Measures of Male Fecundity in Adult Sons. I: International Journal of Environmental Research and Public Health. 2022 ; Bind 19, Nr. 21.

Bibtex

@article{a893d79fcb174496a2cec1fdb185a4f5,
title = "Nitrate in Maternal Drinking Water during Pregnancy and Measures of Male Fecundity in Adult Sons",
abstract = "Animal studies indicate deleterious effects of nitrate exposure on fecundity, but effects in humans are unknown, both for the prenatal and postnatal periods. We aimed to investigate if exposure to nitrate in maternal drinking water during the sensitive period of fetal life is associated with measures of fecundity in the adult sons. In a sub-analysis, the potential effects of nitrate exposure in adulthood were investigated. This cohort included 985 young adult men enrolled in The Fetal Programming of Semen Quality Cohort (FEPOS). Semen characteristics, testes volume and reproductive hormones were analyzed in relation to nitrate concentration in maternal drinking water, using a negative binomial regression model. The nitrate concentration in drinking water was obtained from monitoring data from Danish waterworks that were linked with the mothers' residential address during pregnancy. The median nitrate concentration in maternal drinking water was 2 mg/L. At these low exposure levels, which are far below the World Health Organization's (WHO) guideline value of 50 mg/L, we did not find indications of harmful effects of nitrate on the investigated measures of male fecundity.",
keywords = "prenatal exposure, semen quality, drinking water, nitrate, semen analysis, reproduction, NATIONAL BIRTH COHORT, SEMEN QUALITY, REPRODUCTIVE FUNCTION, NITRITE, ENVIRONMENT, FERTILITY, EXPOSURE, HUMANS, DNA",
author = "Clemmensen, {Pernille Jul} and Nis Brix and Jorg Schullehner and Anne Gaml-Sorensen and Gunnar Toft and T{\o}ttenborg, {Sandra S{\o}gaard} and Ebdrup, {Ninna Hinchely} and Hougaard, {Karin Sorig} and Birgitte Hansen and Torben Sigsgaard and Kolstad, {Henrik Albert} and Bonde, {Jens Peter Ellekilde} and Ramlau-Hansen, {Cecilia Host}",
year = "2022",
doi = "10.3390/ijerph192114428",
language = "English",
volume = "19",
journal = "International Journal of Environmental Research and Public Health",
issn = "1661-7827",
publisher = "MDPI AG",
number = "21",

}

RIS

TY - JOUR

T1 - Nitrate in Maternal Drinking Water during Pregnancy and Measures of Male Fecundity in Adult Sons

AU - Clemmensen, Pernille Jul

AU - Brix, Nis

AU - Schullehner, Jorg

AU - Gaml-Sorensen, Anne

AU - Toft, Gunnar

AU - Tøttenborg, Sandra Søgaard

AU - Ebdrup, Ninna Hinchely

AU - Hougaard, Karin Sorig

AU - Hansen, Birgitte

AU - Sigsgaard, Torben

AU - Kolstad, Henrik Albert

AU - Bonde, Jens Peter Ellekilde

AU - Ramlau-Hansen, Cecilia Host

PY - 2022

Y1 - 2022

N2 - Animal studies indicate deleterious effects of nitrate exposure on fecundity, but effects in humans are unknown, both for the prenatal and postnatal periods. We aimed to investigate if exposure to nitrate in maternal drinking water during the sensitive period of fetal life is associated with measures of fecundity in the adult sons. In a sub-analysis, the potential effects of nitrate exposure in adulthood were investigated. This cohort included 985 young adult men enrolled in The Fetal Programming of Semen Quality Cohort (FEPOS). Semen characteristics, testes volume and reproductive hormones were analyzed in relation to nitrate concentration in maternal drinking water, using a negative binomial regression model. The nitrate concentration in drinking water was obtained from monitoring data from Danish waterworks that were linked with the mothers' residential address during pregnancy. The median nitrate concentration in maternal drinking water was 2 mg/L. At these low exposure levels, which are far below the World Health Organization's (WHO) guideline value of 50 mg/L, we did not find indications of harmful effects of nitrate on the investigated measures of male fecundity.

AB - Animal studies indicate deleterious effects of nitrate exposure on fecundity, but effects in humans are unknown, both for the prenatal and postnatal periods. We aimed to investigate if exposure to nitrate in maternal drinking water during the sensitive period of fetal life is associated with measures of fecundity in the adult sons. In a sub-analysis, the potential effects of nitrate exposure in adulthood were investigated. This cohort included 985 young adult men enrolled in The Fetal Programming of Semen Quality Cohort (FEPOS). Semen characteristics, testes volume and reproductive hormones were analyzed in relation to nitrate concentration in maternal drinking water, using a negative binomial regression model. The nitrate concentration in drinking water was obtained from monitoring data from Danish waterworks that were linked with the mothers' residential address during pregnancy. The median nitrate concentration in maternal drinking water was 2 mg/L. At these low exposure levels, which are far below the World Health Organization's (WHO) guideline value of 50 mg/L, we did not find indications of harmful effects of nitrate on the investigated measures of male fecundity.

KW - prenatal exposure

KW - semen quality

KW - drinking water

KW - nitrate

KW - semen analysis

KW - reproduction

KW - NATIONAL BIRTH COHORT

KW - SEMEN QUALITY

KW - REPRODUCTIVE FUNCTION

KW - NITRITE

KW - ENVIRONMENT

KW - FERTILITY

KW - EXPOSURE

KW - HUMANS

KW - DNA

U2 - 10.3390/ijerph192114428

DO - 10.3390/ijerph192114428

M3 - Journal article

C2 - 36361307

VL - 19

JO - International Journal of Environmental Research and Public Health

JF - International Journal of Environmental Research and Public Health

SN - 1661-7827

IS - 21

M1 - 14428

ER -

ID: 326981415