Long-Term Exposure to Fine Particle Elemental Components and Natural and Cause-Specific Mortality-a Pooled Analysis of Eight European Cohorts within the ELAPSE Project
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Long-Term Exposure to Fine Particle Elemental Components and Natural and Cause-Specific Mortality-a Pooled Analysis of Eight European Cohorts within the ELAPSE Project. / Chen, Jie; Rodopoulou, Sophia; de Hoogh, Kees; Strak, Maciej; Andersen, Zorana J.; Atkinson, Richard; Bauwelinck, Mariska; Bellander, Tom; Brandt, Jorgen; Cesaroni, Giulia; Concin, Hans; Fecht, Daniela; Forastiere, Francesco; Gulliver, John; Hertel, Ole; Hoffmann, Barbara; Hvidtfeldt, Ulla Arthur; Janssen, Nicole A. H.; Joeckel, Karl-Heinz; Jorgensen, Jeanette; Katsouyanni, Klea; Ketzel, Matthias; Klompmaker, Jochem O.; Lager, Anton; Leander, Karin; Liu, Shuo; Ljungman, Petter; MacDonald, Conor J.; Magnusson, Patrik K. E.; Mehta, Amar; Nagel, Gabriele; Oftedal, Bente; Pershagen, Goran; Peters, Annette; Raaschou-Nielsen, Ole; Renzi, Matteo; Rizzuto, Debora; Samoli, Evangelia; van der Schouw, Yvonne T.; Schramm, Sara; Schwarze, Per; Sigsgaard, Torben; Sørensen, Mette; Stafoggia, Massimo; Tjonneland, Anne; Vienneau, Danielle; Weinmayr, Gudrun; Wolf, Kathrin; Brunekreef, Bert; Hoek, Gerard.
I: Environmental Health Perspectives, Bind 129, Nr. 4, 047009, 2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Long-Term Exposure to Fine Particle Elemental Components and Natural and Cause-Specific Mortality-a Pooled Analysis of Eight European Cohorts within the ELAPSE Project
AU - Chen, Jie
AU - Rodopoulou, Sophia
AU - de Hoogh, Kees
AU - Strak, Maciej
AU - Andersen, Zorana J.
AU - Atkinson, Richard
AU - Bauwelinck, Mariska
AU - Bellander, Tom
AU - Brandt, Jorgen
AU - Cesaroni, Giulia
AU - Concin, Hans
AU - Fecht, Daniela
AU - Forastiere, Francesco
AU - Gulliver, John
AU - Hertel, Ole
AU - Hoffmann, Barbara
AU - Hvidtfeldt, Ulla Arthur
AU - Janssen, Nicole A. H.
AU - Joeckel, Karl-Heinz
AU - Jorgensen, Jeanette
AU - Katsouyanni, Klea
AU - Ketzel, Matthias
AU - Klompmaker, Jochem O.
AU - Lager, Anton
AU - Leander, Karin
AU - Liu, Shuo
AU - Ljungman, Petter
AU - MacDonald, Conor J.
AU - Magnusson, Patrik K. E.
AU - Mehta, Amar
AU - Nagel, Gabriele
AU - Oftedal, Bente
AU - Pershagen, Goran
AU - Peters, Annette
AU - Raaschou-Nielsen, Ole
AU - Renzi, Matteo
AU - Rizzuto, Debora
AU - Samoli, Evangelia
AU - van der Schouw, Yvonne T.
AU - Schramm, Sara
AU - Schwarze, Per
AU - Sigsgaard, Torben
AU - Sørensen, Mette
AU - Stafoggia, Massimo
AU - Tjonneland, Anne
AU - Vienneau, Danielle
AU - Weinmayr, Gudrun
AU - Wolf, Kathrin
AU - Brunekreef, Bert
AU - Hoek, Gerard
PY - 2021
Y1 - 2021
N2 - BACKGROUND: Inconsistent associations between long-term exposure to particles with an aerodynamic diameterOBJECTIVES: We investigated the associations between long-term exposure to PM2.5 elemental components and mortality in a large pooled European cohort; to compare health effects of PM2.5 components estimated with two exposure modeling approaches, namely, supervised linear regression (SLR) and random forest (RF) algorithms.METHODS: We pooled data from eight European cohorts with 323,782 participants, average age 49 y at baseline (1985-2005). Residential exposure to 2010 annual average concentration of eight PM2.5 components [copper (Cu), iron (Fe), potassium (K), nickel (Ni), sulfur (S), silicon (Si), vanadium (V), and zinc (Zn)] was estimated with Europe-wide SLR and RF models at a 100 X 100 m scale. We applied Cox proportional hazards models to investigate the associations between components and natural and cause-specific mortality. In addition, two-pollutant analyses were conducted by adjusting each component for PM2.5 mass and nitrogen dioxide (NO2) separately.RESULTS: We observed 46,640 natural-cause deaths with 6,317,235 person-years and an average follow-up of 19.5 y. All SLR-modeled components were statistically significantly associated with natural-cause mortality in single-pollutant models with hazard ratios (HRs) from 1.05 to 1.27. Similar HRs were observed for RE-modeled Cu, Fe, K, S, V, and Zn with wider confidence intervals (CIs). HRs for SLR-modeled Ni, S, Si, V, and Zn remained above unity and (almost) significant after adjustment for both PM2.5 and NO2. HRs only remained (almost) significant for RE-modeled K and V in two-pollutant models. The HRs for V were 1.03 (95% CI: 1.02, 1.05) and 1.06 (95% CI: 1.02, 1.10) for SLR- and RF-modeled exposures, respectively, per 2 ng/m(3), adjusting for PM2.5 mass. Associations with cause-specific mortality were less consistent in two-pollutant models.CONCLUSION: Long-term exposure to V in PM2.5 was most consistently associated with increased mortality. Associations for the other components were weaker for exposure modeled with RE than SLR in two-pollutant models.
AB - BACKGROUND: Inconsistent associations between long-term exposure to particles with an aerodynamic diameterOBJECTIVES: We investigated the associations between long-term exposure to PM2.5 elemental components and mortality in a large pooled European cohort; to compare health effects of PM2.5 components estimated with two exposure modeling approaches, namely, supervised linear regression (SLR) and random forest (RF) algorithms.METHODS: We pooled data from eight European cohorts with 323,782 participants, average age 49 y at baseline (1985-2005). Residential exposure to 2010 annual average concentration of eight PM2.5 components [copper (Cu), iron (Fe), potassium (K), nickel (Ni), sulfur (S), silicon (Si), vanadium (V), and zinc (Zn)] was estimated with Europe-wide SLR and RF models at a 100 X 100 m scale. We applied Cox proportional hazards models to investigate the associations between components and natural and cause-specific mortality. In addition, two-pollutant analyses were conducted by adjusting each component for PM2.5 mass and nitrogen dioxide (NO2) separately.RESULTS: We observed 46,640 natural-cause deaths with 6,317,235 person-years and an average follow-up of 19.5 y. All SLR-modeled components were statistically significantly associated with natural-cause mortality in single-pollutant models with hazard ratios (HRs) from 1.05 to 1.27. Similar HRs were observed for RE-modeled Cu, Fe, K, S, V, and Zn with wider confidence intervals (CIs). HRs for SLR-modeled Ni, S, Si, V, and Zn remained above unity and (almost) significant after adjustment for both PM2.5 and NO2. HRs only remained (almost) significant for RE-modeled K and V in two-pollutant models. The HRs for V were 1.03 (95% CI: 1.02, 1.05) and 1.06 (95% CI: 1.02, 1.10) for SLR- and RF-modeled exposures, respectively, per 2 ng/m(3), adjusting for PM2.5 mass. Associations with cause-specific mortality were less consistent in two-pollutant models.CONCLUSION: Long-term exposure to V in PM2.5 was most consistently associated with increased mortality. Associations for the other components were weaker for exposure modeled with RE than SLR in two-pollutant models.
KW - USE REGRESSION-MODELS
KW - PARTICULATE MATTER
KW - RISK
KW - PROFILE
KW - ESCAPE
KW - PM2.5
KW - MEN
U2 - 10.1289/EHP8368
DO - 10.1289/EHP8368
M3 - Journal article
C2 - 33844598
VL - 129
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
SN - 0091-6765
IS - 4
M1 - 047009
ER -
ID: 272709077