Dietary Intake of 91 Individual Polyphenols and 5-Year Body Weight Change in the EPIC-PANACEA Cohort

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  • Mercedes Gil-Lespinard
  • Jazmín Castañeda
  • Enrique Almanza-Aguilera
  • Jesús Humberto Gómez
  • Cecilie Kyrø
  • Kim Overvad
  • Verena Katzke
  • Matthias B. Schulze
  • Giovanna Masala
  • Claudia Agnoli
  • Maria Santucci de Magistris
  • Rosario Tumino
  • Carlotta Sacerdote
  • Guri Skeie
  • Cristina Lasheras
  • Esther Molina-Montes
  • José María Huerta
  • Aurelio Barricarte
  • Pilar Amiano
  • Emily Sonestedt
  • Marisa da Silva
  • Ingegerd Johansson
  • Johan Hultdin
  • Anne M. May
  • Nita G. Forouhi
  • Alicia K. Heath
  • Heinz Freisling
  • Elisabete Weiderpass
  • Augustin Scalbert
  • Raul Zamora-Ros
Polyphenols are bioactive compounds from plants with antioxidant properties that may have a protective role against body weight gain, with adipose tissue and systemic oxidative stress as potential targets. We aimed to investigate the dietary intake of individual polyphenols and their association with 5-year body weight change in a sub-cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 349,165 adult participants from nine European countries. Polyphenol intake was estimated through country-specific validated dietary questionnaires and the Phenol-Explorer database. Body weight was obtained at recruitment and after a mean follow-up time of 5 years. Associations were estimated using multilevel mixed linear regression models. From 91 polyphenols included, the majority (n = 67) were inversely associated with 5-year body weight change after FDR-correction (q < 0.05). The greatest inverse associations were observed for quercetin 3-O-rhamnoside (change in weight for doubling in intake: −0.071 (95% CI: −0.085; −0.056) kg/5 years). Only 13 polyphenols showed positive associations with body weight gain, mainly from the subclass hydroxycinnamic acids (HCAs) with coffee as the main dietary source, such as 4-caffeoylquinic acid (0.029 (95% CI: 0.021; 0.038) kg/5 years). Individual polyphenols with fruit, tea, cocoa and whole grain cereals as the main dietary sources may contribute to body weight maintenance in adults. Individual HCAs may have different roles in body weight change depending on their dietary source
OriginalsprogEngelsk
Artikelnummer2425
TidsskriftAntioxidants
Vol/bind11
Udgave nummer12
Antal sider15
ISSN2076-3921
DOI
StatusUdgivet - 2022

Bibliografisk note

Funding Information:
This research has been funded by the Instituto De Salud Carlos III through the project PI18/00191 (Co-funded by European Regional Development Fund, ERDF, a way to build Europe). The PANACEA project was funded by the European Union, in the framework of the Public Health Programme (project number: 2005328). The coordination of EPIC is financially supported by International Agency for Research on Cancer (IARC) and also by the Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London which has additional infrastructure support provided by the NIHR Imperial Biomedical Research Centre (BRC). The national cohorts are supported by: Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France); German Cancer Aid, German Cancer Research Center (DKFZ), German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Federal Ministry of Education and Research (BMBF) (Germany); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy, Compagnia di San Paolo and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands); Health Research Fund (FIS)—Instituto de Salud Carlos III (ISCIII), Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology—ICO (Spain); Swedish Cancer Society, Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden); Cancer Research UK (14136 to EPIC-Norfolk; C8221/A29017 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk; MR/M012190/1 to EPIC-Oxford). (United Kingdom). NGF acknowledges support from MRC Epidemiology Unit (MC_UU_0006/3) and from the NIHR Cambridge Biomedical Research Centre diet, nutrition and lifestyle theme (IS-BRC-1215-20014). She is an NIHR Senior Investigator. We thank the CERCA Program/Generalitat de Catalunya for the institutional support to IDIBELL. JC thanks the CONACYT predoctoral fellowship (ID 693636). MG-L, EA-A, and RZ-R were supported by the PFIS (FI19/00185), the “Sara Borrell” (CD20/00071), and the “Miguel Servet II” (CPII20/00009) programmes from the Instituto de Salud Carlos III (Co-funded by European Social Fund (ESF) investing in your future).

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© 2022 by the authors.

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