An inter-nordic prospective study on cytogenetic endpoints and cancer risk
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An inter-nordic prospective study on cytogenetic endpoints and cancer risk. / Brøgger, Anton; Hagmar, Lars; Hansteen, Inger Lise; Heim, Sverre; Högstedt, Benkt; Knudsen, Lisbeth; Lambert, Bo; Linnainmaa, Kaija; Mitelman, Felix; Nordenson, Ingrid; Reuterwall, Christina; Salomaa, Sisko; Skerfving, Staffan; Sorsa, Marja.
I: Cancer Genetics and Cytogenetics, Bind 45, Nr. 1, 03.1990, s. 85-92.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - An inter-nordic prospective study on cytogenetic endpoints and cancer risk
AU - Brøgger, Anton
AU - Hagmar, Lars
AU - Hansteen, Inger Lise
AU - Heim, Sverre
AU - Högstedt, Benkt
AU - Knudsen, Lisbeth
AU - Lambert, Bo
AU - Linnainmaa, Kaija
AU - Mitelman, Felix
AU - Nordenson, Ingrid
AU - Reuterwall, Christina
AU - Salomaa, Sisko
AU - Skerfving, Staffan
AU - Sorsa, Marja
N1 - Funding Information: This project was supported by grants from the Nordic Council of Ministers (42.5:L031, the Swedish Work Environment Fund and the Swedish Cancer Society. The authors thank Aage Andersen, Christina Andcrsson, Robyn Altewell, Oyvind \]chnert. Anneli ()iajiirvi. Eero Pukkala, and Heini Vainio for epidemiologic assistam:o.
PY - 1990/3
Y1 - 1990/3
N2 - To investigate whether high rates of chromosomal aberrations (CAs), sister chromatid exchange (SCE), or micronuclei(MN) in peripheral lymphocytes indicate an increased risk for subsequent cancer, a prospective cohort study of 2.969 subjects cytogenetically examined between 1970 and 1988 in four Swedish, two Finnish, and two Norwegian laboratories was initiated. To standardize for the interlaboratory variation, the results of the three cytogenetic endpoints were trichotomized for each laboratory into "low" (1st to 33rd percentile), "medium" (34th to 66th percentile), and "high" (67th to 100th percentile). Thirty-four cancers had been diagnosed in the cohort during the observation period (1970 to 1985). The point-estimates of the standardized morbidity ratio (SMR) in the three CA strata were 90, 92, and 180, respectively. This trend for a positive association was not statistically significant (p = 0.06). There was no significant trend between SMR and the trichotomized rates of SCE. In the subcohort examined for MN only two cases of cancer had been diagnosed until now. If subjects with "high" frequencies of CA or SCE have a two-fold (or greater) risk of developing cancer as compared with individuals who have "medium" or "low" frequencies, we estimate that there is a likelihood of 80% and 70%, respectively, that this will be detectable as significant (p < 0.05) differences after a further follow-up period of 5 years. Weaker associations between cancer risk and the cytogenetic endpoints would not be possible to evaluate until even later follow-ups.
AB - To investigate whether high rates of chromosomal aberrations (CAs), sister chromatid exchange (SCE), or micronuclei(MN) in peripheral lymphocytes indicate an increased risk for subsequent cancer, a prospective cohort study of 2.969 subjects cytogenetically examined between 1970 and 1988 in four Swedish, two Finnish, and two Norwegian laboratories was initiated. To standardize for the interlaboratory variation, the results of the three cytogenetic endpoints were trichotomized for each laboratory into "low" (1st to 33rd percentile), "medium" (34th to 66th percentile), and "high" (67th to 100th percentile). Thirty-four cancers had been diagnosed in the cohort during the observation period (1970 to 1985). The point-estimates of the standardized morbidity ratio (SMR) in the three CA strata were 90, 92, and 180, respectively. This trend for a positive association was not statistically significant (p = 0.06). There was no significant trend between SMR and the trichotomized rates of SCE. In the subcohort examined for MN only two cases of cancer had been diagnosed until now. If subjects with "high" frequencies of CA or SCE have a two-fold (or greater) risk of developing cancer as compared with individuals who have "medium" or "low" frequencies, we estimate that there is a likelihood of 80% and 70%, respectively, that this will be detectable as significant (p < 0.05) differences after a further follow-up period of 5 years. Weaker associations between cancer risk and the cytogenetic endpoints would not be possible to evaluate until even later follow-ups.
UR - http://www.scopus.com/inward/record.url?scp=0025278236&partnerID=8YFLogxK
U2 - 10.1016/0165-4608(90)90071-H
DO - 10.1016/0165-4608(90)90071-H
M3 - Journal article
C2 - 2302690
AN - SCOPUS:0025278236
VL - 45
SP - 85
EP - 92
JO - Cancer genetics and cytogenetics
JF - Cancer genetics and cytogenetics
SN - 0165-4608
IS - 1
ER -
ID: 343211074