Does recombinant human Epo increase exercise capacity by means other than augmenting oxygen transport?

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Standard

Does recombinant human Epo increase exercise capacity by means other than augmenting oxygen transport? / Lundby, C; Robach, P; Boushel, R; Thomsen, J J; Rasmussen, P; Koskolou, M; Calbet, J A L.

I: Journal of Applied Physiology, Bind 105, Nr. 2, 2008, s. 581-7.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Lundby, C, Robach, P, Boushel, R, Thomsen, JJ, Rasmussen, P, Koskolou, M & Calbet, JAL 2008, 'Does recombinant human Epo increase exercise capacity by means other than augmenting oxygen transport?', Journal of Applied Physiology, bind 105, nr. 2, s. 581-7. https://doi.org/10.1152/japplphysiol.90484.2008

APA

Lundby, C., Robach, P., Boushel, R., Thomsen, J. J., Rasmussen, P., Koskolou, M., & Calbet, J. A. L. (2008). Does recombinant human Epo increase exercise capacity by means other than augmenting oxygen transport? Journal of Applied Physiology, 105(2), 581-7. https://doi.org/10.1152/japplphysiol.90484.2008

Vancouver

Lundby C, Robach P, Boushel R, Thomsen JJ, Rasmussen P, Koskolou M o.a. Does recombinant human Epo increase exercise capacity by means other than augmenting oxygen transport? Journal of Applied Physiology. 2008;105(2):581-7. https://doi.org/10.1152/japplphysiol.90484.2008

Author

Lundby, C ; Robach, P ; Boushel, R ; Thomsen, J J ; Rasmussen, P ; Koskolou, M ; Calbet, J A L. / Does recombinant human Epo increase exercise capacity by means other than augmenting oxygen transport?. I: Journal of Applied Physiology. 2008 ; Bind 105, Nr. 2. s. 581-7.

Bibtex

@article{eed6b2e0f69911ddbf70000ea68e967b,
title = "Does recombinant human Epo increase exercise capacity by means other than augmenting oxygen transport?",
abstract = "This study was performed to test the hypothesis that administration of recombinant human erythropoietin (rHuEpo) in humans increases maximal oxygen consumption by augmenting the maximal oxygen carrying capacity of blood. Systemic and leg oxygen delivery and oxygen uptake were studied during exercise in eight subjects before and after 13 wk of rHuEpo treatment and after isovolemic hemodilution to the same hemoglobin concentration observed before the start of rHuEpo administration. At peak exercise, leg oxygen delivery was increased from 1,777.0+/-102.0 ml/min before rHuEpo treatment to 2,079.8+/-120.7 ml/min after treatment. After hemodilution, oxygen delivery was decreased to the pretreatment value (1,710.3+/-138.1 ml/min). Fractional leg arterial oxygen extraction was unaffected at maximal exercise; hence, maximal leg oxygen uptake increased from 1,511.0+/-130.1 ml/min before treatment to 1,793.0+/-148.7 ml/min with rHuEpo and decreased after hemodilution to 1,428.0+/-111.6 ml/min. Pulmonary oxygen uptake at peak exercise increased from 3,950.0+/-160.7 before administration to 4,254.5+/-178.4 ml/min with rHuEpo and decreased to 4,059.0+/-161.1 ml/min with hemodilution (P=0.22, compared with values before rHuEpo treatment). Blood buffer capacity remained unaffected by rHuEpo treatment and hemodilution. The augmented hematocrit did not compromise peak cardiac output. In summary, in healthy humans, rHuEpo increases maximal oxygen consumption due to augmented systemic and muscular peak oxygen delivery.",
author = "C Lundby and P Robach and R Boushel and Thomsen, {J J} and P Rasmussen and M Koskolou and Calbet, {J A L}",
note = "Keywords: Adult; Biological Transport, Active; Blood Glucose; Capillaries; Cardiac Output; Electrocardiography; Erythropoietin, Recombinant; Exercise; Hemodilution; Humans; Lactic Acid; Male; Muscle, Skeletal; Muscle, Smooth, Vascular; Norepinephrine; Oxygen; Oxygen Consumption; Regional Blood Flow; Rest; Supine Position",
year = "2008",
doi = "10.1152/japplphysiol.90484.2008",
language = "English",
volume = "105",
pages = "581--7",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "2",

}

RIS

TY - JOUR

T1 - Does recombinant human Epo increase exercise capacity by means other than augmenting oxygen transport?

AU - Lundby, C

AU - Robach, P

AU - Boushel, R

AU - Thomsen, J J

AU - Rasmussen, P

AU - Koskolou, M

AU - Calbet, J A L

N1 - Keywords: Adult; Biological Transport, Active; Blood Glucose; Capillaries; Cardiac Output; Electrocardiography; Erythropoietin, Recombinant; Exercise; Hemodilution; Humans; Lactic Acid; Male; Muscle, Skeletal; Muscle, Smooth, Vascular; Norepinephrine; Oxygen; Oxygen Consumption; Regional Blood Flow; Rest; Supine Position

PY - 2008

Y1 - 2008

N2 - This study was performed to test the hypothesis that administration of recombinant human erythropoietin (rHuEpo) in humans increases maximal oxygen consumption by augmenting the maximal oxygen carrying capacity of blood. Systemic and leg oxygen delivery and oxygen uptake were studied during exercise in eight subjects before and after 13 wk of rHuEpo treatment and after isovolemic hemodilution to the same hemoglobin concentration observed before the start of rHuEpo administration. At peak exercise, leg oxygen delivery was increased from 1,777.0+/-102.0 ml/min before rHuEpo treatment to 2,079.8+/-120.7 ml/min after treatment. After hemodilution, oxygen delivery was decreased to the pretreatment value (1,710.3+/-138.1 ml/min). Fractional leg arterial oxygen extraction was unaffected at maximal exercise; hence, maximal leg oxygen uptake increased from 1,511.0+/-130.1 ml/min before treatment to 1,793.0+/-148.7 ml/min with rHuEpo and decreased after hemodilution to 1,428.0+/-111.6 ml/min. Pulmonary oxygen uptake at peak exercise increased from 3,950.0+/-160.7 before administration to 4,254.5+/-178.4 ml/min with rHuEpo and decreased to 4,059.0+/-161.1 ml/min with hemodilution (P=0.22, compared with values before rHuEpo treatment). Blood buffer capacity remained unaffected by rHuEpo treatment and hemodilution. The augmented hematocrit did not compromise peak cardiac output. In summary, in healthy humans, rHuEpo increases maximal oxygen consumption due to augmented systemic and muscular peak oxygen delivery.

AB - This study was performed to test the hypothesis that administration of recombinant human erythropoietin (rHuEpo) in humans increases maximal oxygen consumption by augmenting the maximal oxygen carrying capacity of blood. Systemic and leg oxygen delivery and oxygen uptake were studied during exercise in eight subjects before and after 13 wk of rHuEpo treatment and after isovolemic hemodilution to the same hemoglobin concentration observed before the start of rHuEpo administration. At peak exercise, leg oxygen delivery was increased from 1,777.0+/-102.0 ml/min before rHuEpo treatment to 2,079.8+/-120.7 ml/min after treatment. After hemodilution, oxygen delivery was decreased to the pretreatment value (1,710.3+/-138.1 ml/min). Fractional leg arterial oxygen extraction was unaffected at maximal exercise; hence, maximal leg oxygen uptake increased from 1,511.0+/-130.1 ml/min before treatment to 1,793.0+/-148.7 ml/min with rHuEpo and decreased after hemodilution to 1,428.0+/-111.6 ml/min. Pulmonary oxygen uptake at peak exercise increased from 3,950.0+/-160.7 before administration to 4,254.5+/-178.4 ml/min with rHuEpo and decreased to 4,059.0+/-161.1 ml/min with hemodilution (P=0.22, compared with values before rHuEpo treatment). Blood buffer capacity remained unaffected by rHuEpo treatment and hemodilution. The augmented hematocrit did not compromise peak cardiac output. In summary, in healthy humans, rHuEpo increases maximal oxygen consumption due to augmented systemic and muscular peak oxygen delivery.

U2 - 10.1152/japplphysiol.90484.2008

DO - 10.1152/japplphysiol.90484.2008

M3 - Journal article

C2 - 18535134

VL - 105

SP - 581

EP - 587

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 2

ER -

ID: 10211086