Seasonal variation in biopsy-proven giant cell arteritis in Eastern Denmark from 1990-2018
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Seasonal variation in biopsy-proven giant cell arteritis in Eastern Denmark from 1990-2018. / Konig, Elisabeth Bay; Stormly Hansen, Michael; Foldager, Jonathan; Siersma, Volkert; Loft, Annika; Terslev, Lene; Møller Døhn, Uffe; Radmer Jensen, Mads; Wiencke, Anne Katrine; Faber, Carsten; Hamann, Steffen; Heegaard, Steffen.
I: Acta Ophthalmologica, Bind 99, Nr. 5, 2021, s. 527-532.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Seasonal variation in biopsy-proven giant cell arteritis in Eastern Denmark from 1990-2018
AU - Konig, Elisabeth Bay
AU - Stormly Hansen, Michael
AU - Foldager, Jonathan
AU - Siersma, Volkert
AU - Loft, Annika
AU - Terslev, Lene
AU - Møller Døhn, Uffe
AU - Radmer Jensen, Mads
AU - Wiencke, Anne Katrine
AU - Faber, Carsten
AU - Hamann, Steffen
AU - Heegaard, Steffen
PY - 2021
Y1 - 2021
N2 - Purpose The purpose of this study was to investigate seasonal variation in cases of biopsy-proven GCA in eastern Denmark in a 29-year period.Methods Pathology records of all temporal artery biopsies in eastern Denmark between 1990 and 2018 were reviewed. For each patient, data were collected which included age, sex, date of birth and biopsy result. Seasonality was evaluated using logistic regression and Poisson regression analysis. Lastly, an explorative pilot study was conducted to investigate a possible association between three weather parameters (average temperature, amount of rain and hours of sunshine) and the biopsy outcome.Results One thousand three hundred twenty-three biopsies were included of which 336 fulfilled objective criteria for GCA diagnosis. Mean age at diagnosis was 75.6 years (range 52-94 years). Among the biopsy-proven cases of GCA, there were 223 women (66.3%, mean age 76.2 years) and 113 men (33.7%, mean age 74.4 years) giving a female to male ratio of 1.97:1. The peak occurrence of GCA was in the 70-79 years age group. Statistical analysis of seasonal variation showed an increased risk of a positive biopsy during summer compared to autumn (p = 0.037). No association between the three weather parameters and the biopsy outcome was found.Conclusion In this study of biopsy-proven GCA in a large Danish patient cohort, the occurrence of GCA showed seasonal variation with higher occurrence in the summer months when compared to autumn. Future studies pooling all cases of GCA worldwide are needed to determine seasonality in the occurrence of GCA.
AB - Purpose The purpose of this study was to investigate seasonal variation in cases of biopsy-proven GCA in eastern Denmark in a 29-year period.Methods Pathology records of all temporal artery biopsies in eastern Denmark between 1990 and 2018 were reviewed. For each patient, data were collected which included age, sex, date of birth and biopsy result. Seasonality was evaluated using logistic regression and Poisson regression analysis. Lastly, an explorative pilot study was conducted to investigate a possible association between three weather parameters (average temperature, amount of rain and hours of sunshine) and the biopsy outcome.Results One thousand three hundred twenty-three biopsies were included of which 336 fulfilled objective criteria for GCA diagnosis. Mean age at diagnosis was 75.6 years (range 52-94 years). Among the biopsy-proven cases of GCA, there were 223 women (66.3%, mean age 76.2 years) and 113 men (33.7%, mean age 74.4 years) giving a female to male ratio of 1.97:1. The peak occurrence of GCA was in the 70-79 years age group. Statistical analysis of seasonal variation showed an increased risk of a positive biopsy during summer compared to autumn (p = 0.037). No association between the three weather parameters and the biopsy outcome was found.Conclusion In this study of biopsy-proven GCA in a large Danish patient cohort, the occurrence of GCA showed seasonal variation with higher occurrence in the summer months when compared to autumn. Future studies pooling all cases of GCA worldwide are needed to determine seasonality in the occurrence of GCA.
KW - giant cell arteritis
KW - arteritis temporalis
KW - seasonal variation
KW - seasonality
KW - POLYMYALGIA-RHEUMATICA
KW - TEMPORAL ARTERITIS
KW - EPIDEMIOLOGY
KW - CLASSIFICATION
KW - PATTERN
KW - ONSET
U2 - 10.1111/aos.14675
DO - 10.1111/aos.14675
M3 - Journal article
C2 - 33211398
VL - 99
SP - 527
EP - 532
JO - Acta Ophthalmologica
JF - Acta Ophthalmologica
SN - 1755-375X
IS - 5
ER -
ID: 252466800