Differential effects of interleukin 1α and 1β on cultured human and rat thyroid epithelial cells

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Standard

Differential effects of interleukin 1α and 1β on cultured human and rat thyroid epithelial cells. / Rasmussen, A. K.; Kayser, L.; Bech, K.; Feldt-Rasmussen, U.; Perrild, H.; Bendtzen, K.

I: Acta Endocrinologica, Bind 122, Nr. 4, 1990, s. 520-526.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Rasmussen, AK, Kayser, L, Bech, K, Feldt-Rasmussen, U, Perrild, H & Bendtzen, K 1990, 'Differential effects of interleukin 1α and 1β on cultured human and rat thyroid epithelial cells', Acta Endocrinologica, bind 122, nr. 4, s. 520-526. https://doi.org/10.1530/acta.0.1220520

APA

Rasmussen, A. K., Kayser, L., Bech, K., Feldt-Rasmussen, U., Perrild, H., & Bendtzen, K. (1990). Differential effects of interleukin 1α and 1β on cultured human and rat thyroid epithelial cells. Acta Endocrinologica, 122(4), 520-526. https://doi.org/10.1530/acta.0.1220520

Vancouver

Rasmussen AK, Kayser L, Bech K, Feldt-Rasmussen U, Perrild H, Bendtzen K. Differential effects of interleukin 1α and 1β on cultured human and rat thyroid epithelial cells. Acta Endocrinologica. 1990;122(4):520-526. https://doi.org/10.1530/acta.0.1220520

Author

Rasmussen, A. K. ; Kayser, L. ; Bech, K. ; Feldt-Rasmussen, U. ; Perrild, H. ; Bendtzen, K. / Differential effects of interleukin 1α and 1β on cultured human and rat thyroid epithelial cells. I: Acta Endocrinologica. 1990 ; Bind 122, Nr. 4. s. 520-526.

Bibtex

@article{80d5524e59af40d68a737b902faaacd5,
title = "Differential effects of interleukin 1α and 1β on cultured human and rat thyroid epithelial cells",
abstract = "The effects of human recombinant interleukin 1α (20 pg/l-20 μg/l) and 1β (200 pg/l-20 μg/l) on two systems of thyroid cells have been compared. The thyroglobulin and cAMP secretion and the DNA content of human thyroid cells cultured in monolayer and of continuously grown rat thyroid cells, Fischer rat thyroid cell line have been studied. The growth of the rat thyroid cell line was inhibited by interleukin 1β (20 ng/l-20 μg/l), but not by interleukin 1α. None of the cytokines changed the cAMP production of the rat thyroid cells. In contrast, both cAMP production and thyroglobulin secretion were inhibited dose-dependently by the cytokines in human thyroid cells in secondary cultures. These results caution the interpretation and extrapolation of changes induced by interleukin 1 from one cell system to the other.",
author = "Rasmussen, {A. K.} and L. Kayser and K. Bech and U. Feldt-Rasmussen and H. Perrild and K. Bendtzen",
year = "1990",
doi = "10.1530/acta.0.1220520",
language = "English",
volume = "122",
pages = "520--526",
journal = "European Journal of Endocrinology",
issn = "0804-4643",
publisher = "BioScientifica Ltd.",
number = "4",

}

RIS

TY - JOUR

T1 - Differential effects of interleukin 1α and 1β on cultured human and rat thyroid epithelial cells

AU - Rasmussen, A. K.

AU - Kayser, L.

AU - Bech, K.

AU - Feldt-Rasmussen, U.

AU - Perrild, H.

AU - Bendtzen, K.

PY - 1990

Y1 - 1990

N2 - The effects of human recombinant interleukin 1α (20 pg/l-20 μg/l) and 1β (200 pg/l-20 μg/l) on two systems of thyroid cells have been compared. The thyroglobulin and cAMP secretion and the DNA content of human thyroid cells cultured in monolayer and of continuously grown rat thyroid cells, Fischer rat thyroid cell line have been studied. The growth of the rat thyroid cell line was inhibited by interleukin 1β (20 ng/l-20 μg/l), but not by interleukin 1α. None of the cytokines changed the cAMP production of the rat thyroid cells. In contrast, both cAMP production and thyroglobulin secretion were inhibited dose-dependently by the cytokines in human thyroid cells in secondary cultures. These results caution the interpretation and extrapolation of changes induced by interleukin 1 from one cell system to the other.

AB - The effects of human recombinant interleukin 1α (20 pg/l-20 μg/l) and 1β (200 pg/l-20 μg/l) on two systems of thyroid cells have been compared. The thyroglobulin and cAMP secretion and the DNA content of human thyroid cells cultured in monolayer and of continuously grown rat thyroid cells, Fischer rat thyroid cell line have been studied. The growth of the rat thyroid cell line was inhibited by interleukin 1β (20 ng/l-20 μg/l), but not by interleukin 1α. None of the cytokines changed the cAMP production of the rat thyroid cells. In contrast, both cAMP production and thyroglobulin secretion were inhibited dose-dependently by the cytokines in human thyroid cells in secondary cultures. These results caution the interpretation and extrapolation of changes induced by interleukin 1 from one cell system to the other.

UR - http://www.scopus.com/inward/record.url?scp=0025240040&partnerID=8YFLogxK

U2 - 10.1530/acta.0.1220520

DO - 10.1530/acta.0.1220520

M3 - Journal article

C2 - 2159205

AN - SCOPUS:0025240040

VL - 122

SP - 520

EP - 526

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

SN - 0804-4643

IS - 4

ER -

ID: 335355266