Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and breast cancer risk in 9 European countries
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and breast cancer risk in 9 European countries. / Fiolet, Thibault; Casagrande, Corinne; Nicolas, Geneviève; Horvath, Zsuzsanna; Frenoy, Pauline; Weiderpass, Elisabete; Katzke, Verena; Kaaks, Rudolf; Rodriguez-Barranco, Miguel; Panico, Salvatore; Sacerdote, Carlotta; Manjer, Jonas; Sonestedt, Emily; Grioni, Sara; Agudo, Antonio; Rylander, Charlotta; Haugdahl Nøst, Therese; Skeie, Guri; Tjønneland, Anne; Raaschou-Nielsen, Ole; Ardanaz, Eva; Amiano, Pilar; Dolores Chirlaque López, María; Schulze, Matthias B; Wennberg, Maria; Harlid, Sophia; Cairat, Manon; Kvaskoff, Marina; Huybrechts, Inge; Romana Mancini, Francesca.
I: Environment International, Bind 163, 107213, 2022.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and breast cancer risk in 9 European countries
AU - Fiolet, Thibault
AU - Casagrande, Corinne
AU - Nicolas, Geneviève
AU - Horvath, Zsuzsanna
AU - Frenoy, Pauline
AU - Weiderpass, Elisabete
AU - Katzke, Verena
AU - Kaaks, Rudolf
AU - Rodriguez-Barranco, Miguel
AU - Panico, Salvatore
AU - Sacerdote, Carlotta
AU - Manjer, Jonas
AU - Sonestedt, Emily
AU - Grioni, Sara
AU - Agudo, Antonio
AU - Rylander, Charlotta
AU - Haugdahl Nøst, Therese
AU - Skeie, Guri
AU - Tjønneland, Anne
AU - Raaschou-Nielsen, Ole
AU - Ardanaz, Eva
AU - Amiano, Pilar
AU - Dolores Chirlaque López, María
AU - Schulze, Matthias B
AU - Wennberg, Maria
AU - Harlid, Sophia
AU - Cairat, Manon
AU - Kvaskoff, Marina
AU - Huybrechts, Inge
AU - Romana Mancini, Francesca
N1 - Copyright © 2022. Published by Elsevier Ltd.
PY - 2022
Y1 - 2022
N2 - BACKGROUND: Dioxins and polychlorobiphenyls (PCBs) are persistent organic pollutants that have demonstrated endocrine disrupting properties. Several of these chemicals are carcinogenic and positive associations have been suggested with breast cancer risk. In general population, diet represents the main source of exposure.METHODS: Associations between dietary intake of 17 dioxins and 35 PCBs and breast cancer were evaluated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort from nine European countries using multivariable Cox regressions. The present study included 318,607 women (mean ± SD age: 50.7 ± 9.7) with 13,241 incident invasive breast cancers and a median follow-up of 14.9 years (IQR = 13.5-16.4). Dietary intake of dioxins and PCBs was assessed combining EPIC food consumption data with food contamination data provided by the European Food Safety Authority.RESULTS: Exposure to dioxins, dioxins + Dioxin-Like-PCBs, Dioxin-Like-PCBs (DL-PCBs), and Non-Dioxin-Like-PCBs (NDL-PCBs) estimated from reported dietary intakes were not associated with breast cancer incidence, with the following hazard ratios (HRs) and 95% confidence intervals for an increment of 1 SD: HRdioxins = 1.00 (0.98 to 1.02), HRdioxins+DL-PCB = 1.01 (0.98 to 1.03), HRDL-PCB = 1.01 (0.98 to 1.03), and HRNDL-PCB = 1.01 (0.99 to 1.03). Results remained unchanged when analyzing intakes as quintile groups, as well as when analyses were run separately per country, or separating breast cancer cases based on estrogen receptor status or after further adjustments on main contributing food groups to PCBs and dioxins intake and nutritional factors.CONCLUSIONS: This large European prospective study does not support the hypothesis of an association between dietary intake of dioxins and PCBs and breast cancer risk.
AB - BACKGROUND: Dioxins and polychlorobiphenyls (PCBs) are persistent organic pollutants that have demonstrated endocrine disrupting properties. Several of these chemicals are carcinogenic and positive associations have been suggested with breast cancer risk. In general population, diet represents the main source of exposure.METHODS: Associations between dietary intake of 17 dioxins and 35 PCBs and breast cancer were evaluated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort from nine European countries using multivariable Cox regressions. The present study included 318,607 women (mean ± SD age: 50.7 ± 9.7) with 13,241 incident invasive breast cancers and a median follow-up of 14.9 years (IQR = 13.5-16.4). Dietary intake of dioxins and PCBs was assessed combining EPIC food consumption data with food contamination data provided by the European Food Safety Authority.RESULTS: Exposure to dioxins, dioxins + Dioxin-Like-PCBs, Dioxin-Like-PCBs (DL-PCBs), and Non-Dioxin-Like-PCBs (NDL-PCBs) estimated from reported dietary intakes were not associated with breast cancer incidence, with the following hazard ratios (HRs) and 95% confidence intervals for an increment of 1 SD: HRdioxins = 1.00 (0.98 to 1.02), HRdioxins+DL-PCB = 1.01 (0.98 to 1.03), HRDL-PCB = 1.01 (0.98 to 1.03), and HRNDL-PCB = 1.01 (0.99 to 1.03). Results remained unchanged when analyzing intakes as quintile groups, as well as when analyses were run separately per country, or separating breast cancer cases based on estrogen receptor status or after further adjustments on main contributing food groups to PCBs and dioxins intake and nutritional factors.CONCLUSIONS: This large European prospective study does not support the hypothesis of an association between dietary intake of dioxins and PCBs and breast cancer risk.
KW - Adult
KW - Breast Neoplasms/epidemiology
KW - Dioxins/adverse effects
KW - Eating
KW - Female
KW - Food Contamination/analysis
KW - Humans
KW - Male
KW - Middle Aged
KW - Polychlorinated Biphenyls/adverse effects
KW - Prospective Studies
U2 - 10.1016/j.envint.2022.107213
DO - 10.1016/j.envint.2022.107213
M3 - Journal article
C2 - 35364416
VL - 163
JO - Environment international
JF - Environment international
SN - 0160-4120
M1 - 107213
ER -
ID: 307733177