TY - JOUR

T1 - Circulating inflammatory biomarkers, adipokines and breast cancer risk-a case-control study nested within the EPIC cohort

AU - Cairat, Manon

AU - Rinaldi, Sabina

AU - Navionis, Anne-Sophie

AU - Romieu, Isabelle

AU - Biessy, Carine

AU - Viallon, Vivian

AU - Olsen, Anja

AU - Tjønneland, Anne

AU - Fournier, Agnes

AU - Severi, Gianluca

AU - Kvaskoff, Marina

AU - Fortner, Renee T.

AU - Kaaks, Rudolf

AU - Aleksandrova, Krasimira

AU - Schulze, Matthias B.

AU - Masala, Giovanna

AU - Tumino, Rosario

AU - Sieri, Sabina

AU - Grasso, Chiara

AU - Mattiello, Amalia

AU - Gram, Inger T.

AU - Olsen, Karina Standahl

AU - Agudo, Antonio

AU - Etxezarreta, Pilar Amiano

AU - Sanchez, Maria-Jose

AU - Santiuste, Carmen

AU - Barricarte, Aurelio

AU - Monninkhof, Evelyn

AU - Hiensch, Anouk E.

AU - Muller, David

AU - Merritt, Melissa A.

AU - Travis, Ruth C.

AU - Weiderpass, Elisabete

AU - Gunter, Marc J.

AU - Dossus, Laure

PY - 2022

Y1 - 2022

N2 - Background Inflammation has been hypothesized to play a role in the development and progression of breast cancer and might differently impact breast cancer risk among pre and postmenopausal women. We performed a nested case-control study to examine whether pre-diagnostic circulating concentrations of adiponectin, leptin, c-reactive protein (CRP), tumour necrosis factor-alpha, interferon-gamma and 6 interleukins were associated with breast cancer risk, overall and by menopausal status. Methods Pre-diagnostic levels of inflammatory biomarkers were measured in plasma from 1558 case-control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. We used conditional logistic regression to estimate the odds ratios (ORs) of breast cancer at blood collection, per one standard deviation increase in biomarker concentration. Results Cases were diagnosed at a mean age of 61.4 years on average 8.6 years after blood collection. No statistically significant association was observed between inflammatory markers and breast cancer risk overall. In premenopausal women, borderline significant inverse associations were observed for leptin, leptin-to-adiponectin ratio and CRP [OR= 0.89 (0.77-1.03), OR= 0.88 (0.76-1.01) and OR= 0.87 (0.75-1.01), respectively] while positive associations were observed among postmenopausal women [OR= 1.16 (1.05-1.29), OR= 1.11 (1.01-1.23), OR= 1.10 (0.99-1.22), respectively]. Adjustment for BMI strengthened the estimates in premenopausal women [leptin: OR = 0.83 (0.68-1.00), leptin-to-adiponectin ratio: OR = 0.80 (0.66-0.97), CRP: OR = 0.85 (0.72-1.00)] but attenuated the estimates in postmenopausal women [leptin: OR = 1.09 (0.96-1.24), leptin-to-adiponectin ratio: OR = 1.02 (0.89-1.16), CRP: OR = 1.04 (0.92-1.16)]. Conclusions Associations between CRP, leptin and leptin-to-adiponectin ratio with breast cancer risk may represent the dual effect of obesity by menopausal status although this deserves further investigation.

AB - Background Inflammation has been hypothesized to play a role in the development and progression of breast cancer and might differently impact breast cancer risk among pre and postmenopausal women. We performed a nested case-control study to examine whether pre-diagnostic circulating concentrations of adiponectin, leptin, c-reactive protein (CRP), tumour necrosis factor-alpha, interferon-gamma and 6 interleukins were associated with breast cancer risk, overall and by menopausal status. Methods Pre-diagnostic levels of inflammatory biomarkers were measured in plasma from 1558 case-control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. We used conditional logistic regression to estimate the odds ratios (ORs) of breast cancer at blood collection, per one standard deviation increase in biomarker concentration. Results Cases were diagnosed at a mean age of 61.4 years on average 8.6 years after blood collection. No statistically significant association was observed between inflammatory markers and breast cancer risk overall. In premenopausal women, borderline significant inverse associations were observed for leptin, leptin-to-adiponectin ratio and CRP [OR= 0.89 (0.77-1.03), OR= 0.88 (0.76-1.01) and OR= 0.87 (0.75-1.01), respectively] while positive associations were observed among postmenopausal women [OR= 1.16 (1.05-1.29), OR= 1.11 (1.01-1.23), OR= 1.10 (0.99-1.22), respectively]. Adjustment for BMI strengthened the estimates in premenopausal women [leptin: OR = 0.83 (0.68-1.00), leptin-to-adiponectin ratio: OR = 0.80 (0.66-0.97), CRP: OR = 0.85 (0.72-1.00)] but attenuated the estimates in postmenopausal women [leptin: OR = 1.09 (0.96-1.24), leptin-to-adiponectin ratio: OR = 1.02 (0.89-1.16), CRP: OR = 1.04 (0.92-1.16)]. Conclusions Associations between CRP, leptin and leptin-to-adiponectin ratio with breast cancer risk may represent the dual effect of obesity by menopausal status although this deserves further investigation.

KW - Breast cancer

KW - Inflammation

KW - Biomarkers

KW - Menopausal status

KW - Anthropometry

KW - C-REACTIVE PROTEIN

KW - ADIPONECTIN

KW - LEPTIN

KW - WOMEN

KW - ASSOCIATION

KW - VALIDITY

KW - WEIGHT

KW - INDEX

U2 - 10.1186/s12916-022-02319-y

DO - 10.1186/s12916-022-02319-y

M3 - Journal article

C2 - 35430795

VL - 20

JO - BMC Medicine

JF - BMC Medicine

SN - 1741-7015

IS - 1

M1 - 118

ER -