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Body size at different ages and risk of six cancers : a Mendelian randomization and prospective cohort study. / Mariosa, Daniela; Smith-Byrne, Karl; Richardson, Tom G; Ferrari, Pietro; Gunter, Marc J; Papadimitriou, Nikos; Murphy, Neil; Christakoudi, Sofia; Tsilidis, Konstantinos K; Riboli, Elio; Muller, David; Purdue, Mark P; Chanock, Stephen J; Hung, Rayjean J; Amos, Christopher I; O'Mara, Tracy A; Amiano, Pilar; Pasanisi, Fabrizio; Rodriguez-Barranco, Miguel; Krogh, Vittorio; Tjønneland, Anne; Halkjær, Jytte; Perez-Cornago, Aurora; Chirlaque, María-Dolores; Skeie, Guri; Rylander, Charlotta; Borch, Kristin Benjaminsen; Aune, Dagfinn; Heath, Alicia K; Ward, Heather A; Schulze, Matthias; Bonet, Catalina; Weiderpass, Elisabete; Smith, George Davey; Brennan, Paul; Johansson, Mattias.
I:
Journal of the National Cancer Institute, Bind 114, Nr. 9, 2022, s. 1296–1300.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Mariosa, D, Smith-Byrne, K, Richardson, TG, Ferrari, P, Gunter, MJ, Papadimitriou, N, Murphy, N, Christakoudi, S, Tsilidis, KK, Riboli, E, Muller, D, Purdue, MP, Chanock, SJ, Hung, RJ, Amos, CI, O'Mara, TA, Amiano, P, Pasanisi, F, Rodriguez-Barranco, M, Krogh, V
, Tjønneland, A, Halkjær, J, Perez-Cornago, A, Chirlaque, M-D, Skeie, G, Rylander, C, Borch, KB, Aune, D, Heath, AK, Ward, HA, Schulze, M, Bonet, C, Weiderpass, E, Smith, GD, Brennan, P & Johansson, M 2022, '
Body size at different ages and risk of six cancers: a Mendelian randomization and prospective cohort study',
Journal of the National Cancer Institute, bind 114, nr. 9, s. 1296–1300.
https://doi.org/10.1093/jnci/djac061APA
Mariosa, D., Smith-Byrne, K., Richardson, T. G., Ferrari, P., Gunter, M. J., Papadimitriou, N., Murphy, N., Christakoudi, S., Tsilidis, K. K., Riboli, E., Muller, D., Purdue, M. P., Chanock, S. J., Hung, R. J., Amos, C. I., O'Mara, T. A., Amiano, P., Pasanisi, F., Rodriguez-Barranco, M., ... Johansson, M. (2022).
Body size at different ages and risk of six cancers: a Mendelian randomization and prospective cohort study.
Journal of the National Cancer Institute,
114(9), 1296–1300.
https://doi.org/10.1093/jnci/djac061Vancouver
Mariosa D, Smith-Byrne K, Richardson TG, Ferrari P, Gunter MJ, Papadimitriou N o.a.
Body size at different ages and risk of six cancers: a Mendelian randomization and prospective cohort study.
Journal of the National Cancer Institute. 2022;114(9):1296–1300.
https://doi.org/10.1093/jnci/djac061Author
Mariosa, Daniela ; Smith-Byrne, Karl ; Richardson, Tom G ; Ferrari, Pietro ; Gunter, Marc J ; Papadimitriou, Nikos ; Murphy, Neil ; Christakoudi, Sofia ; Tsilidis, Konstantinos K ; Riboli, Elio ; Muller, David ; Purdue, Mark P ; Chanock, Stephen J ; Hung, Rayjean J ; Amos, Christopher I ; O'Mara, Tracy A ; Amiano, Pilar ; Pasanisi, Fabrizio ; Rodriguez-Barranco, Miguel ; Krogh, Vittorio ; Tjønneland, Anne ; Halkjær, Jytte ; Perez-Cornago, Aurora ; Chirlaque, María-Dolores ; Skeie, Guri ; Rylander, Charlotta ; Borch, Kristin Benjaminsen ; Aune, Dagfinn ; Heath, Alicia K ; Ward, Heather A ; Schulze, Matthias ; Bonet, Catalina ; Weiderpass, Elisabete ; Smith, George Davey ; Brennan, Paul ; Johansson, Mattias. / Body size at different ages and risk of six cancers : a Mendelian randomization and prospective cohort study. I: Journal of the National Cancer Institute. 2022 ; Bind 114, Nr. 9. s. 1296–1300.
Bibtex
@article{98826f6128c1437b97747a2d8486dba7,
title = "Body size at different ages and risk of six cancers: a Mendelian randomization and prospective cohort study",
abstract = "It is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for six obesity-related cancers, we performed univariable and multivariable analyses using i) Mendelian randomization (MR) analysis and ii) longitudinal analyses in prospective cohorts. Both the MR and longitudinal analyses indicated that larger body size at age 10 was associated with higher risk of endometrial (ORMR=1.61, 95%CI = 1.23-2.11) and kidney cancer (ORMR=1.40, 95%CI = 1.09-1.80). These associations were attenuated after accounting for adult body size in both the MR and cohort analyses. Early life BMI was not consistently associated with the other investigated cancers. The lack of clear independent risk associations suggests that early life BMI influences endometrial and kidney cancer risk mainly through pathways that are common with adult BMI.",
author = "Daniela Mariosa and Karl Smith-Byrne and Richardson, {Tom G} and Pietro Ferrari and Gunter, {Marc J} and Nikos Papadimitriou and Neil Murphy and Sofia Christakoudi and Tsilidis, {Konstantinos K} and Elio Riboli and David Muller and Purdue, {Mark P} and Chanock, {Stephen J} and Hung, {Rayjean J} and Amos, {Christopher I} and O'Mara, {Tracy A} and Pilar Amiano and Fabrizio Pasanisi and Miguel Rodriguez-Barranco and Vittorio Krogh and Anne Tj{\o}nneland and Jytte Halkj{\ae}r and Aurora Perez-Cornago and Mar{\'i}a-Dolores Chirlaque and Guri Skeie and Charlotta Rylander and Borch, {Kristin Benjaminsen} and Dagfinn Aune and Heath, {Alicia K} and Ward, {Heather A} and Matthias Schulze and Catalina Bonet and Elisabete Weiderpass and Smith, {George Davey} and Paul Brennan and Mattias Johansson",
note = "{\textcopyright} The Author(s) 2022. Published by Oxford University Press.",
year = "2022",
doi = "10.1093/jnci/djac061",
language = "English",
volume = "114",
pages = "1296–1300",
journal = "National Cancer Institute. Journal (Online)",
issn = "1460-2105",
publisher = "Oxford University Press",
number = "9",
}
RIS
TY - JOUR
T1 - Body size at different ages and risk of six cancers
T2 - a Mendelian randomization and prospective cohort study
AU - Mariosa, Daniela
AU - Smith-Byrne, Karl
AU - Richardson, Tom G
AU - Ferrari, Pietro
AU - Gunter, Marc J
AU - Papadimitriou, Nikos
AU - Murphy, Neil
AU - Christakoudi, Sofia
AU - Tsilidis, Konstantinos K
AU - Riboli, Elio
AU - Muller, David
AU - Purdue, Mark P
AU - Chanock, Stephen J
AU - Hung, Rayjean J
AU - Amos, Christopher I
AU - O'Mara, Tracy A
AU - Amiano, Pilar
AU - Pasanisi, Fabrizio
AU - Rodriguez-Barranco, Miguel
AU - Krogh, Vittorio
AU - Tjønneland, Anne
AU - Halkjær, Jytte
AU - Perez-Cornago, Aurora
AU - Chirlaque, María-Dolores
AU - Skeie, Guri
AU - Rylander, Charlotta
AU - Borch, Kristin Benjaminsen
AU - Aune, Dagfinn
AU - Heath, Alicia K
AU - Ward, Heather A
AU - Schulze, Matthias
AU - Bonet, Catalina
AU - Weiderpass, Elisabete
AU - Smith, George Davey
AU - Brennan, Paul
AU - Johansson, Mattias
N1 - © The Author(s) 2022. Published by Oxford University Press.
PY - 2022
Y1 - 2022
N2 - It is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for six obesity-related cancers, we performed univariable and multivariable analyses using i) Mendelian randomization (MR) analysis and ii) longitudinal analyses in prospective cohorts. Both the MR and longitudinal analyses indicated that larger body size at age 10 was associated with higher risk of endometrial (ORMR=1.61, 95%CI = 1.23-2.11) and kidney cancer (ORMR=1.40, 95%CI = 1.09-1.80). These associations were attenuated after accounting for adult body size in both the MR and cohort analyses. Early life BMI was not consistently associated with the other investigated cancers. The lack of clear independent risk associations suggests that early life BMI influences endometrial and kidney cancer risk mainly through pathways that are common with adult BMI.
AB - It is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for six obesity-related cancers, we performed univariable and multivariable analyses using i) Mendelian randomization (MR) analysis and ii) longitudinal analyses in prospective cohorts. Both the MR and longitudinal analyses indicated that larger body size at age 10 was associated with higher risk of endometrial (ORMR=1.61, 95%CI = 1.23-2.11) and kidney cancer (ORMR=1.40, 95%CI = 1.09-1.80). These associations were attenuated after accounting for adult body size in both the MR and cohort analyses. Early life BMI was not consistently associated with the other investigated cancers. The lack of clear independent risk associations suggests that early life BMI influences endometrial and kidney cancer risk mainly through pathways that are common with adult BMI.
U2 - 10.1093/jnci/djac061
DO - 10.1093/jnci/djac061
M3 - Journal article
C2 - 35438160
VL - 114
SP - 1296
EP - 1300
JO - National Cancer Institute. Journal (Online)
JF - National Cancer Institute. Journal (Online)
SN - 1460-2105
IS - 9
ER -
