Association between vitamin K-1 intake and mortality in the Danish Diet, Cancer, and Health cohort
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- Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort
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Reported associations between vitamin K-1 and both all-cause and cause-specific mortality are conflicting. The 56,048 participants from the Danish Diet, Cancer, and Health prospective cohort study, with a median [IQR] age of 56 [52-60] years at entry and of whom 47.6% male, were followed for 23 years, with 14,083 reported deaths. Of these, 5015 deaths were CVD-related, and 6342 deaths were cancer-related. Intake of vitamin K-1 (phylloquinone) was estimated from a food-frequency questionnaire (FFQ), and its relationship with mortality outcomes was investigated using Cox proportional hazards models. A moderate to high (87-192 mu g/d) intake of vitamin K-1 was associated with a lower risk of all-cause [HR (95%CI) for quintile 5 vs quintile 1: 0.76 (0.72, 0.79)], cardiovascular disease (CVD)-related [quintile 5 vs quintile 1: 0.72 (0.66, 0.79)], and cancer-related mortality [quintile 5 vs quintile 1: 0.80 (0.75, 0.86)], after adjusting for demographic and lifestyle confounders. The association between vitamin K-1 intake and cardiovascular disease-related mortality was present in all subpopulations (categorised according to sex, smoking status, diabetes status, and hypertension status), while the association with cancer-related mortality was only present in current/former smokers (p for interaction = 0.002). These findings suggest that promoting adequate intakes of foods rich in vitamin K-1 may help to reduce all-cause, CVD-related, and cancer-related mortality at the population level.
Originalsprog | Engelsk |
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Tidsskrift | European Journal of Epidemiology |
Vol/bind | 36 |
Sider (fra-til) | 1005–1014 |
Antal sider | 10 |
ISSN | 0393-2990 |
DOI | |
Status | Udgivet - 2021 |
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ID: 281330319