Effectiveness evaluation of an antenatal care intervention addressing disparities to improve perinatal outcomes in Denmark: a nationwide register-based analysis of a cluster randomized controlled trial (MAMAACT)

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To evaluate whether MAMAACT, an antenatal care (ANC) intervention, aiming at reducing ethnic and social disparities in perinatal mortality, affected perinatal health outcomes.

Cluster randomized controlled trial.

19 out of 20 maternity wards in Denmark.

All newborn children within a pre-implementation period (2014–2017) or the implementation period (2018–2019) (N=188 658).

A six-hour training session for midwives in intercultural communication and cultural competence, two follow-up dialogue meetings, and health education materials for pregnant women on warning signs of pregnancy complications ꟷ in six languages.

Nationwide register-based analysis of the MAMAACT cluster randomized controlled trial. Mixed-effects logistic regression models were used to estimate the change in outcomes from pre- to post-implementation in the intervention group relative to the control group. Results were obtained for the overall study population and for children born to immigrants from low-middle income countries, separately. Models were adjusted for a priori selected confounders.

Outcome Measure
A composite perinatal mortality and morbidity outcome, including stillbirths, neonatal deaths, Apgar score <7, umbilical arterial pH <7.0, admissions to a neonatal intensive care unit (NICU) >48 hours, and NICU admissions for mechanical ventilation. Additional outcomes were the individual measures.

The intervention increased the risk of the composite outcome (aOR 1.16, 95% CI: 0.99–1.34), mainly driven by differences in NICU admission risk (composite outcome excl. NICU, aOR 0.98, 95% CI: 0.84-1.14). The intervention slightly increased the risk of low Apgar score and decreased the risk of low arterial pH, however, reflecting small differences in absolute numbers. Other outcomes were unchanged.

Overall, the MAMAACT intervention did not improve the composite perinatal mortality and morbidity outcome (when excluding NICU admissions). . The lack of effects may be due to contextual factors including organizational barriers in ANC hindering the midwives from changing practices
TidsskriftBJOG : an international journal of obstetrics and gynaecology
Udgave nummer7
Sider (fra-til) 759-769
Antal sider11
StatusUdgivet - 2023

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