TY - JOUR

T1 - Relationship between bisphenol A, bisphenol S, and bisphenol F and serum uric acid concentrations among school-aged children

AU - Lee, Yun Jeong

AU - Lim, Youn-Hee

AU - Shin, Choong Ho

AU - Kim, Bung-Nyun

AU - Kim, Johanna Inhyang

AU - Hong, Yun-Chul

AU - Cho, Yong Min

AU - Lee, Young Ah

PY - 2022

Y1 - 2022

N2 - BackgroundHyperuricemia has a suspected relationship with hypertension, metabolic syndrome, kidney disease, and cardiovascular disease. Endocrine disruptors may affect uric acid metabolism; however, few epidemiologic studies have been performed in children regarding newly developed bisphenol A (BPA) substitutes. We evaluated the associations between BPA, bisphenol S (BPS), and bisphenol F (BPF) exposure and serum uric acid concentrations in 6-year-old Korean children.MethodsFrom the Environment and Development of Children cohort study, six-year-old children (N = 489; 251 boys) who underwent an examination during 2015-2017 were included. Anthropometry, questionnaires, and biological samples were evaluated. BPA, BPS, and BPF levels were measured from spot urine samples, and log-transformed or categorized into groups for analysis. We constructed linear regression models adjusting for age, sex, urinary creatinine levels, body mass index z-scores, and estimated glomerular filtration rates.ResultsMean serum uric level was 4.2 mg dL(-1) (0.8 SD) without sex-differences. Among the three bisphenols, higher BPS exposure was associated with increased serum uric acid concentrations (P-value for trend = 0.002). When BPS levels were categorized into three groups (non-detection < 0.02 mu g L-1 vs. medium BPS; 0.02-0.05 mu g L-1 vs. high BPS > 0.05 mu g L-1), the high BPS group showed higher serum uric acid concentrations (by 0.26 mg dL(-1), P= 0.003) than the non-detection group after adjusting for covariates, which was significant in boys but not girls.DiscussionsUrinary BPS levels was positively associated with serum uric acid concentrations in 6-year-old children, and the association was more pronounced in boys. Considering the increasing use of BPS and concerning effect of hyperuricemia on health outcomes, their positive relationship should be investigated further.

AB - BackgroundHyperuricemia has a suspected relationship with hypertension, metabolic syndrome, kidney disease, and cardiovascular disease. Endocrine disruptors may affect uric acid metabolism; however, few epidemiologic studies have been performed in children regarding newly developed bisphenol A (BPA) substitutes. We evaluated the associations between BPA, bisphenol S (BPS), and bisphenol F (BPF) exposure and serum uric acid concentrations in 6-year-old Korean children.MethodsFrom the Environment and Development of Children cohort study, six-year-old children (N = 489; 251 boys) who underwent an examination during 2015-2017 were included. Anthropometry, questionnaires, and biological samples were evaluated. BPA, BPS, and BPF levels were measured from spot urine samples, and log-transformed or categorized into groups for analysis. We constructed linear regression models adjusting for age, sex, urinary creatinine levels, body mass index z-scores, and estimated glomerular filtration rates.ResultsMean serum uric level was 4.2 mg dL(-1) (0.8 SD) without sex-differences. Among the three bisphenols, higher BPS exposure was associated with increased serum uric acid concentrations (P-value for trend = 0.002). When BPS levels were categorized into three groups (non-detection < 0.02 mu g L-1 vs. medium BPS; 0.02-0.05 mu g L-1 vs. high BPS > 0.05 mu g L-1), the high BPS group showed higher serum uric acid concentrations (by 0.26 mg dL(-1), P= 0.003) than the non-detection group after adjusting for covariates, which was significant in boys but not girls.DiscussionsUrinary BPS levels was positively associated with serum uric acid concentrations in 6-year-old children, and the association was more pronounced in boys. Considering the increasing use of BPS and concerning effect of hyperuricemia on health outcomes, their positive relationship should be investigated further.

KW - NUTRITION EXAMINATION SURVEY

KW - URINARY CONCENTRATIONS

KW - BLOOD-PRESSURE

KW - METABOLIC SYNDROME

KW - OXIDATIVE STRESS

KW - NATIONAL-HEALTH

KW - UNITED-STATES

KW - HYPERURICEMIA

KW - EXPOSURE

KW - OBESITY

U2 - 10.1371/journal.pone.0268503

DO - 10.1371/journal.pone.0268503

M3 - Journal article

C2 - 35709251

VL - 17

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 6

M1 - 0268503

ER -