Acetaminophen metabolism by the perfused rat liver twelve hours after acetaminophen overdose

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Standard

Acetaminophen metabolism by the perfused rat liver twelve hours after acetaminophen overdose. / Poulsen, Henrik E.; Lerche, Anette; Skovgaard, Lene T.

I: Biochemical Pharmacology, Bind 34, Nr. 20, 15.10.1985, s. 3729-3733.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Poulsen, HE, Lerche, A & Skovgaard, LT 1985, 'Acetaminophen metabolism by the perfused rat liver twelve hours after acetaminophen overdose', Biochemical Pharmacology, bind 34, nr. 20, s. 3729-3733. https://doi.org/10.1016/0006-2952(85)90238-2

APA

Poulsen, H. E., Lerche, A., & Skovgaard, L. T. (1985). Acetaminophen metabolism by the perfused rat liver twelve hours after acetaminophen overdose. Biochemical Pharmacology, 34(20), 3729-3733. https://doi.org/10.1016/0006-2952(85)90238-2

Vancouver

Poulsen HE, Lerche A, Skovgaard LT. Acetaminophen metabolism by the perfused rat liver twelve hours after acetaminophen overdose. Biochemical Pharmacology. 1985 okt. 15;34(20):3729-3733. https://doi.org/10.1016/0006-2952(85)90238-2

Author

Poulsen, Henrik E. ; Lerche, Anette ; Skovgaard, Lene T. / Acetaminophen metabolism by the perfused rat liver twelve hours after acetaminophen overdose. I: Biochemical Pharmacology. 1985 ; Bind 34, Nr. 20. s. 3729-3733.

Bibtex

@article{8b3e0c42a6774de898ee3c143dd40e45,
title = "Acetaminophen metabolism by the perfused rat liver twelve hours after acetaminophen overdose",
abstract = "The effect of a toxic dose of acetaminophen on the hepatic conjugations of acetaminophen was studied in single pass perfused livers from rats given acetaminophen overdose 12 hr prior to perfusion and from control rats. Four different acetaminophen concentrations (0.1-6 mmol/1) were used in each perfusion. Glucuronidation of acetaminophen was increased and sulfation of acetaminophen occurred at an unchanged rate in acetaminophen damaged livers as compared to control livers. Hepatic glutathione concentrations declined to about 0.4μmol/g liver during perfusion, possibly due to excretion of glutathione to perfusion medium, but in spite of this the formation of glutathione conjugates was increased with acetaminophen concentrations increasing up to about 5 mmol. We conclude that decreased sulfation, glucuronidation and glutathione conjugation in the liver is not present in the early development of acetaminophen-induced hepatic damage.",
author = "Poulsen, {Henrik E.} and Anette Lerche and Skovgaard, {Lene T.}",
year = "1985",
month = oct,
day = "15",
doi = "10.1016/0006-2952(85)90238-2",
language = "English",
volume = "34",
pages = "3729--3733",
journal = "Biochemical Pharmacology",
issn = "0006-2952",
publisher = "Elsevier",
number = "20",

}

RIS

TY - JOUR

T1 - Acetaminophen metabolism by the perfused rat liver twelve hours after acetaminophen overdose

AU - Poulsen, Henrik E.

AU - Lerche, Anette

AU - Skovgaard, Lene T.

PY - 1985/10/15

Y1 - 1985/10/15

N2 - The effect of a toxic dose of acetaminophen on the hepatic conjugations of acetaminophen was studied in single pass perfused livers from rats given acetaminophen overdose 12 hr prior to perfusion and from control rats. Four different acetaminophen concentrations (0.1-6 mmol/1) were used in each perfusion. Glucuronidation of acetaminophen was increased and sulfation of acetaminophen occurred at an unchanged rate in acetaminophen damaged livers as compared to control livers. Hepatic glutathione concentrations declined to about 0.4μmol/g liver during perfusion, possibly due to excretion of glutathione to perfusion medium, but in spite of this the formation of glutathione conjugates was increased with acetaminophen concentrations increasing up to about 5 mmol. We conclude that decreased sulfation, glucuronidation and glutathione conjugation in the liver is not present in the early development of acetaminophen-induced hepatic damage.

AB - The effect of a toxic dose of acetaminophen on the hepatic conjugations of acetaminophen was studied in single pass perfused livers from rats given acetaminophen overdose 12 hr prior to perfusion and from control rats. Four different acetaminophen concentrations (0.1-6 mmol/1) were used in each perfusion. Glucuronidation of acetaminophen was increased and sulfation of acetaminophen occurred at an unchanged rate in acetaminophen damaged livers as compared to control livers. Hepatic glutathione concentrations declined to about 0.4μmol/g liver during perfusion, possibly due to excretion of glutathione to perfusion medium, but in spite of this the formation of glutathione conjugates was increased with acetaminophen concentrations increasing up to about 5 mmol. We conclude that decreased sulfation, glucuronidation and glutathione conjugation in the liver is not present in the early development of acetaminophen-induced hepatic damage.

UR - http://www.scopus.com/inward/record.url?scp=0022229944&partnerID=8YFLogxK

U2 - 10.1016/0006-2952(85)90238-2

DO - 10.1016/0006-2952(85)90238-2

M3 - Journal article

C2 - 4052111

AN - SCOPUS:0022229944

VL - 34

SP - 3729

EP - 3733

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

SN - 0006-2952

IS - 20

ER -

ID: 259167585