Testicular Growth During Puberty in Boys With and Without a History of Congenital Cryptorchidism
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Testicular Growth During Puberty in Boys With and Without a History of Congenital Cryptorchidism. / Sadov, Sergey; Koskenniemi, Jaakko J; Virtanen, Helena E; Perheentupa, Antti; Petersen, Jørgen H; Skakkebaek, Niels E; Main, Katharina M; Toppari, Jorma.
In: The Journal of Clinical Endocrinology & Metabolism, Vol. 101, No. 6, 06.2016, p. 2570–2577.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Testicular Growth During Puberty in Boys With and Without a History of Congenital Cryptorchidism
AU - Sadov, Sergey
AU - Koskenniemi, Jaakko J
AU - Virtanen, Helena E
AU - Perheentupa, Antti
AU - Petersen, Jørgen H
AU - Skakkebaek, Niels E
AU - Main, Katharina M
AU - Toppari, Jorma
PY - 2016/6
Y1 - 2016/6
N2 - CONTEXT: The pattern of testicular growth during puberty may provide important information about early testicular damage and reproductive potential in adulthood.OBJECTIVE: To evaluate pubertal testicular growth in boys with congenital cryptorchidism and controls.DESIGN: Longitudinal case-control study.SETTING: Andrological Research Center, University of Turku.PARTICIPANTS: Altogether, 119 boys participated: 51 cases with a history of congenital cryptorchidism and 65 controls fulfilled the inclusion criteria.INTERVENTION: None.MAIN OUTCOME MEASURES: Testicular volume by an orchidometer (mL) and ultrasound (mL), testicular length by a ruler (mm), and onset of pubertal testicular growth (y). Longitudinal testicular growth was analyzed with a nonlinear mixed-effect model.RESULTS: The mean age of the onset of pubertal testicular growth (age at the attainment of >3 mL by orchidometer) was 11.7 and 11.8 years in cryptorchid cases and controls, respectively. The difference between cases and controls was not significant. Modeled postpubertal testicular size was smaller among bilaterally and unilaterally undescended testis than in controls. There was a high level of agreement between testicular sizes of 3 mL by orchidometer and 25 mm by ruler as cut-offs in definition of the onset of puberty. An orchidometer size of 3 mL and ruler length of 25 mm corresponded to 1.6 and 1.7 mL by ultrasound (with Lambert's formula), respectively.CONCLUSIONS: Testicular growth in puberty was impaired in congenitally cryptorchid boys. This suggests a poor perinatal development of the cryptorchid testis. The timing of the onset of pubertal testicular growth, however, did not differ which suggests an intact hypothalamic-pituitary axis.
AB - CONTEXT: The pattern of testicular growth during puberty may provide important information about early testicular damage and reproductive potential in adulthood.OBJECTIVE: To evaluate pubertal testicular growth in boys with congenital cryptorchidism and controls.DESIGN: Longitudinal case-control study.SETTING: Andrological Research Center, University of Turku.PARTICIPANTS: Altogether, 119 boys participated: 51 cases with a history of congenital cryptorchidism and 65 controls fulfilled the inclusion criteria.INTERVENTION: None.MAIN OUTCOME MEASURES: Testicular volume by an orchidometer (mL) and ultrasound (mL), testicular length by a ruler (mm), and onset of pubertal testicular growth (y). Longitudinal testicular growth was analyzed with a nonlinear mixed-effect model.RESULTS: The mean age of the onset of pubertal testicular growth (age at the attainment of >3 mL by orchidometer) was 11.7 and 11.8 years in cryptorchid cases and controls, respectively. The difference between cases and controls was not significant. Modeled postpubertal testicular size was smaller among bilaterally and unilaterally undescended testis than in controls. There was a high level of agreement between testicular sizes of 3 mL by orchidometer and 25 mm by ruler as cut-offs in definition of the onset of puberty. An orchidometer size of 3 mL and ruler length of 25 mm corresponded to 1.6 and 1.7 mL by ultrasound (with Lambert's formula), respectively.CONCLUSIONS: Testicular growth in puberty was impaired in congenitally cryptorchid boys. This suggests a poor perinatal development of the cryptorchid testis. The timing of the onset of pubertal testicular growth, however, did not differ which suggests an intact hypothalamic-pituitary axis.
KW - Journal Article
U2 - 10.1210/jc.2015-3329
DO - 10.1210/jc.2015-3329
M3 - Journal article
C2 - 27049351
VL - 101
SP - 2570
EP - 2577
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 6
ER -
ID: 167505311