Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes. / Burgdorf, Kristoffer Sølvsten; Sandholt, Camilla Helene; Sparsø, Thomas; Andersen, Gitte; Witte, Daniel R; Jørgensen, Torben; Sandbaek, Anelli; Lauritzen, Torsten; Sørensen, Thorkild I A; Madsbad, Sten; Hansen, Torben; Pedersen, Oluf.

In: European Journal of Endocrinology, Vol. 163, No. 1, 01.07.2010, p. 81-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Burgdorf, KS, Sandholt, CH, Sparsø, T, Andersen, G, Witte, DR, Jørgensen, T, Sandbaek, A, Lauritzen, T, Sørensen, TIA, Madsbad, S, Hansen, T & Pedersen, O 2010, 'Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes', European Journal of Endocrinology, vol. 163, no. 1, pp. 81-7. https://doi.org/10.1530/EJE-10-0068

APA

Burgdorf, K. S., Sandholt, C. H., Sparsø, T., Andersen, G., Witte, D. R., Jørgensen, T., Sandbaek, A., Lauritzen, T., Sørensen, T. I. A., Madsbad, S., Hansen, T., & Pedersen, O. (2010). Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes. European Journal of Endocrinology, 163(1), 81-7. https://doi.org/10.1530/EJE-10-0068

Vancouver

Burgdorf KS, Sandholt CH, Sparsø T, Andersen G, Witte DR, Jørgensen T et al. Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes. European Journal of Endocrinology. 2010 Jul 1;163(1):81-7. https://doi.org/10.1530/EJE-10-0068

Author

Burgdorf, Kristoffer Sølvsten ; Sandholt, Camilla Helene ; Sparsø, Thomas ; Andersen, Gitte ; Witte, Daniel R ; Jørgensen, Torben ; Sandbaek, Anelli ; Lauritzen, Torsten ; Sørensen, Thorkild I A ; Madsbad, Sten ; Hansen, Torben ; Pedersen, Oluf. / Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes. In: European Journal of Endocrinology. 2010 ; Vol. 163, No. 1. pp. 81-7.

Bibtex

@article{f132763df2e3494cbbde52c8f28c6cc0,
title = "Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes",
abstract = "Lipin-1, encoded by LPIN1, is expressed in the major metabolically active tissues. Decreased expression of lipin-1 in adipose tissue correlates with increased insulin resistance, and tagging of the LPIN1 locus has shown that rs33997857, rs6744682, and rs6708316 associate with metabolic phenotypes, specifically body mass index (BMI) and fasting serum lipid levels, both on the individual single-nucleotide polymorphism level and with a three-marker haplotype. Our aim was to validate the reported findings in the Danish population.",
keywords = "Adult, Body Mass Index, Case-Control Studies, Denmark, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genetic Variation, Genotype, Haplotypes, Humans, Male, Middle Aged, Nuclear Proteins, Obesity, Waist Circumference",
author = "Burgdorf, {Kristoffer S{\o}lvsten} and Sandholt, {Camilla Helene} and Thomas Spars{\o} and Gitte Andersen and Witte, {Daniel R} and Torben J{\o}rgensen and Anelli Sandbaek and Torsten Lauritzen and S{\o}rensen, {Thorkild I A} and Sten Madsbad and Torben Hansen and Oluf Pedersen",
year = "2010",
month = jul,
day = "1",
doi = "10.1530/EJE-10-0068",
language = "English",
volume = "163",
pages = "81--7",
journal = "European Journal of Endocrinology",
issn = "0804-4643",
publisher = "BioScientifica Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes

AU - Burgdorf, Kristoffer Sølvsten

AU - Sandholt, Camilla Helene

AU - Sparsø, Thomas

AU - Andersen, Gitte

AU - Witte, Daniel R

AU - Jørgensen, Torben

AU - Sandbaek, Anelli

AU - Lauritzen, Torsten

AU - Sørensen, Thorkild I A

AU - Madsbad, Sten

AU - Hansen, Torben

AU - Pedersen, Oluf

PY - 2010/7/1

Y1 - 2010/7/1

N2 - Lipin-1, encoded by LPIN1, is expressed in the major metabolically active tissues. Decreased expression of lipin-1 in adipose tissue correlates with increased insulin resistance, and tagging of the LPIN1 locus has shown that rs33997857, rs6744682, and rs6708316 associate with metabolic phenotypes, specifically body mass index (BMI) and fasting serum lipid levels, both on the individual single-nucleotide polymorphism level and with a three-marker haplotype. Our aim was to validate the reported findings in the Danish population.

AB - Lipin-1, encoded by LPIN1, is expressed in the major metabolically active tissues. Decreased expression of lipin-1 in adipose tissue correlates with increased insulin resistance, and tagging of the LPIN1 locus has shown that rs33997857, rs6744682, and rs6708316 associate with metabolic phenotypes, specifically body mass index (BMI) and fasting serum lipid levels, both on the individual single-nucleotide polymorphism level and with a three-marker haplotype. Our aim was to validate the reported findings in the Danish population.

KW - Adult

KW - Body Mass Index

KW - Case-Control Studies

KW - Denmark

KW - Diabetes Mellitus, Type 2

KW - European Continental Ancestry Group

KW - Female

KW - Genetic Predisposition to Disease

KW - Genetic Variation

KW - Genotype

KW - Haplotypes

KW - Humans

KW - Male

KW - Middle Aged

KW - Nuclear Proteins

KW - Obesity

KW - Waist Circumference

U2 - 10.1530/EJE-10-0068

DO - 10.1530/EJE-10-0068

M3 - Journal article

C2 - 20356931

VL - 163

SP - 81

EP - 87

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

SN - 0804-4643

IS - 1

ER -

ID: 33502175