Schizophrenia: from the brain to peripheral markers. A consensus paper of the WFSBP task force on biological markers
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Schizophrenia: from the brain to peripheral markers. A consensus paper of the WFSBP task force on biological markers. / Stober, Gerald; Ben-Shachar, Dorit; Cardon, M; Falkai, Peter; Fonteh, Alfred N; Gawlik, Micha; Glenthøj, Birte Yding; Grunblatt, Edna; Jablensky, Assen; Kim, Yong-Ku; Kornhuber, Johannes; McNeil, Thomas F; Muller, Norbert; Oranje, Bob; Saito, Toshikazu; Saoud, Mohamed; Schmitt, Andrea; Schwartz, Michal; Thome, Johannes; Uzbekov, Marat; Durany, Nuria; Riederer, Peter; Stober, Gerald; Ben-Shachar, Dorit; Cardon, M; Falkai, Peter; Fonteh, Alfred N; Gawlik, Micha; Glenthøj, Birte Yding; Grunblatt, Edna; Jablensky, Assen; Kim, Yong-Ku; Kornhuber, Johannes; McNeil, Thomas F; Muller, Norbert; Oranje, Bob; Saito, Toshikazu; Saoud, Mohamed; Schmitt, Andrea; Schwartz, Michal; Thome, Johannes; Uzbekov, Marat; Durany, Nuria; Riederer, Peter.
In: World Journal of Biological Psychiatry, Vol. 10, No. 2, 2009, p. 127-55.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Schizophrenia: from the brain to peripheral markers. A consensus paper of the WFSBP task force on biological markers
AU - Stober, Gerald
AU - Ben-Shachar, Dorit
AU - Cardon, M
AU - Falkai, Peter
AU - Fonteh, Alfred N
AU - Gawlik, Micha
AU - Glenthøj, Birte Yding
AU - Grunblatt, Edna
AU - Jablensky, Assen
AU - Kim, Yong-Ku
AU - Kornhuber, Johannes
AU - McNeil, Thomas F
AU - Muller, Norbert
AU - Oranje, Bob
AU - Saito, Toshikazu
AU - Saoud, Mohamed
AU - Schmitt, Andrea
AU - Schwartz, Michal
AU - Thome, Johannes
AU - Uzbekov, Marat
AU - Durany, Nuria
AU - Riederer, Peter
AU - Stober, Gerald
AU - Ben-Shachar, Dorit
AU - Cardon, M
AU - Falkai, Peter
AU - Fonteh, Alfred N
AU - Gawlik, Micha
AU - Glenthøj, Birte Yding
AU - Grunblatt, Edna
AU - Jablensky, Assen
AU - Kim, Yong-Ku
AU - Kornhuber, Johannes
AU - McNeil, Thomas F
AU - Muller, Norbert
AU - Oranje, Bob
AU - Saito, Toshikazu
AU - Saoud, Mohamed
AU - Schmitt, Andrea
AU - Schwartz, Michal
AU - Thome, Johannes
AU - Uzbekov, Marat
AU - Durany, Nuria
AU - Riederer, Peter
N1 - Keywords: Biological Markers; Brain; Chromosome Mapping; Genetic Markers; Genetic Predisposition to Disease; Humans; Phenotype; Schizophrenia; Schizophrenic Psychology
PY - 2009
Y1 - 2009
N2 - Objective. The phenotypic complexity, together with the multifarious nature of the so-called "schizophrenic psychoses", limits our ability to form a simple and logical biologically based hypothesis for the disease group. Biological markers are defined as biochemical, physiological or anatomical traits that are specific to particular conditions. An important aim of biomarker discovery is the detection of disease correlates that can be used as diagnostic tools. Method. A selective review of the WFSBP Task Force on Biological Markers in schizophrenia is provided from the central nervous system to phenotypes, functional brain systems, chromosomal loci with potential genetic markers to the peripheral systems. Results. A number of biological measures have been proposed to be correlated with schizophrenia. At present, not a single biological trait in schizophrenia is available which achieves sufficient specificity, selectivity and is based on causal pathology and predictive validity to be recommended as diagnostic marker. Conclusions. With the emergence of new technologies and rigorous phenotypic subclassification the identification of genetic bases and assessment of dynamic disease related alterations will hopefully come to a new stage in the complex field of psychiatric research.
AB - Objective. The phenotypic complexity, together with the multifarious nature of the so-called "schizophrenic psychoses", limits our ability to form a simple and logical biologically based hypothesis for the disease group. Biological markers are defined as biochemical, physiological or anatomical traits that are specific to particular conditions. An important aim of biomarker discovery is the detection of disease correlates that can be used as diagnostic tools. Method. A selective review of the WFSBP Task Force on Biological Markers in schizophrenia is provided from the central nervous system to phenotypes, functional brain systems, chromosomal loci with potential genetic markers to the peripheral systems. Results. A number of biological measures have been proposed to be correlated with schizophrenia. At present, not a single biological trait in schizophrenia is available which achieves sufficient specificity, selectivity and is based on causal pathology and predictive validity to be recommended as diagnostic marker. Conclusions. With the emergence of new technologies and rigorous phenotypic subclassification the identification of genetic bases and assessment of dynamic disease related alterations will hopefully come to a new stage in the complex field of psychiatric research.
U2 - 10.1080/15622970902898980
DO - 10.1080/15622970902898980
M3 - Journal article
C2 - 19396704
VL - 10
SP - 127
EP - 155
JO - World Journal of Biological Psychiatry
JF - World Journal of Biological Psychiatry
SN - 1562-2975
IS - 2
ER -
ID: 21359961