Risk factors for 48-hours mortality after prehospital treatment of opioid overdose
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Risk factors for 48-hours mortality after prehospital treatment of opioid overdose. / Wichmann, Sine; Nielsen, Søren Loumann; Siersma, Volkert Dirk; Rasmussen, Lars S.
In: Emergency Medicine Journal, Vol. 30, No. 3, 2013, p. 223-225.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Risk factors for 48-hours mortality after prehospital treatment of opioid overdose
AU - Wichmann, Sine
AU - Nielsen, Søren Loumann
AU - Siersma, Volkert Dirk
AU - Rasmussen, Lars S
PY - 2013
Y1 - 2013
N2 - INTRODUCTION: Opioid overdose is commonly treated by prehospital emergency services and the majority of the patients are discharged immediately after treatment and a short observation period. There is a minor risk for rebound opioid toxicity and other life-threatening conditions might occur after such episodes. The authors describe the short-term outcome and identify risk factors for death within 48 h after prehospital treatment of opioid overdose in Copenhagen, the capital of Denmark. METHODS: Data on all cases of opioid overdose treated by the medical emergency care unit between 1994 and 2003 were recorded prospectively. Risk factors for death within 48 h after initial medical emergency care unit contact were analysed in a multivariable logistic regression analysis. RESULTS: The authors recorded 4762 episodes of opioid overdose, covering 1967 unique identified patients. A total of 78 patients (8.4%, 95% CI 7.0 to 10.4) died within 48 h in the period 1999-2003, and 85% (66/78) of these had cardiac arrest and died. The authors found age >50 years and overdose during the weekend significantly associated with 48-h mortality. Gender, former episodes of opioid overdose, time of the day, month or year were not significantly associated with increased mortality. CONCLUSIONS: The author found a 48-hours mortality of 8.4%. Advanced age and opioid overdose in the weekends were significant risk factors. Release on scene after treatment was associated with a very small risk.
AB - INTRODUCTION: Opioid overdose is commonly treated by prehospital emergency services and the majority of the patients are discharged immediately after treatment and a short observation period. There is a minor risk for rebound opioid toxicity and other life-threatening conditions might occur after such episodes. The authors describe the short-term outcome and identify risk factors for death within 48 h after prehospital treatment of opioid overdose in Copenhagen, the capital of Denmark. METHODS: Data on all cases of opioid overdose treated by the medical emergency care unit between 1994 and 2003 were recorded prospectively. Risk factors for death within 48 h after initial medical emergency care unit contact were analysed in a multivariable logistic regression analysis. RESULTS: The authors recorded 4762 episodes of opioid overdose, covering 1967 unique identified patients. A total of 78 patients (8.4%, 95% CI 7.0 to 10.4) died within 48 h in the period 1999-2003, and 85% (66/78) of these had cardiac arrest and died. The authors found age >50 years and overdose during the weekend significantly associated with 48-h mortality. Gender, former episodes of opioid overdose, time of the day, month or year were not significantly associated with increased mortality. CONCLUSIONS: The author found a 48-hours mortality of 8.4%. Advanced age and opioid overdose in the weekends were significant risk factors. Release on scene after treatment was associated with a very small risk.
U2 - 10.1136/emermed-2012-201124
DO - 10.1136/emermed-2012-201124
M3 - Journal article
C2 - 22505303
VL - 30
SP - 223
EP - 225
JO - Emergency Medicine Journal
JF - Emergency Medicine Journal
SN - 1472-0205
IS - 3
ER -
ID: 120022256