Pubertal Progression and Reproductive Hormones in Healthy Girls With Transient Thelarche
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Pubertal Progression and Reproductive Hormones in Healthy Girls With Transient Thelarche. / Johansen, Marie Lindhardt; Hagen, Casper P.; Mieritz, Mikkel G.; Wolthers, Ole D.; Heuck, Carsten; Petersen, Jørgen Holm; Juul, Anders.
In: The Journal of clinical endocrinology and metabolism, Vol. 102, No. 3, 01.03.2017, p. 1001-1008.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Pubertal Progression and Reproductive Hormones in Healthy Girls With Transient Thelarche
AU - Johansen, Marie Lindhardt
AU - Hagen, Casper P.
AU - Mieritz, Mikkel G.
AU - Wolthers, Ole D.
AU - Heuck, Carsten
AU - Petersen, Jørgen Holm
AU - Juul, Anders
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Context: Detailed evaluation of pubertal progression in girls from longitudinal studies is sparse, and the phenomenon of transient thelarche (TT), defined as the appearance, regression, and subsequent reappearance of breast buds, in healthy girls remains undescribed.Objective: To describe TT in terms of pubertal progression, growth, genotypes, and reproductive hormones and to apply new puberty nomograms for breast stages, pubic hair, and menarche.Design: A prospective, longitudinal population-based study.Patients or Other Participants: Ninety-eight healthy Danish schoolchildren (Caucasian girls) followed longitudinally as part of the COPENHAGEN Puberty Study were included in the evaluation of TT. A total of 1466 girls from 2 cross-sectional studies were included in the creation of the puberty nomograms.Intervention(s): None.Main Outcome Measure(s): Pubertal progression, specifically thelarche, reproductive hormones, genotype, and growth.Results: Twelve of 98 (12%) girls experienced TT. A larger proportion of girls with TT entered puberty by the pubarche pathway (50%) compared with girls with normal progression (15.4%), P = 0.014. Girls with TT progressed through puberty normally when evaluated using puberty nomograms. Reproductive hormones and growth velocity were lower at the first (transient) thelarche than the second (permanent) thelarche.Conclusion: TT is a frequent phenomenon that appears to be a peripheral occurrence independent of central puberty. It does not appear to affect subsequent pubertal progression as evaluated by our new puberty nomograms.
AB - Context: Detailed evaluation of pubertal progression in girls from longitudinal studies is sparse, and the phenomenon of transient thelarche (TT), defined as the appearance, regression, and subsequent reappearance of breast buds, in healthy girls remains undescribed.Objective: To describe TT in terms of pubertal progression, growth, genotypes, and reproductive hormones and to apply new puberty nomograms for breast stages, pubic hair, and menarche.Design: A prospective, longitudinal population-based study.Patients or Other Participants: Ninety-eight healthy Danish schoolchildren (Caucasian girls) followed longitudinally as part of the COPENHAGEN Puberty Study were included in the evaluation of TT. A total of 1466 girls from 2 cross-sectional studies were included in the creation of the puberty nomograms.Intervention(s): None.Main Outcome Measure(s): Pubertal progression, specifically thelarche, reproductive hormones, genotype, and growth.Results: Twelve of 98 (12%) girls experienced TT. A larger proportion of girls with TT entered puberty by the pubarche pathway (50%) compared with girls with normal progression (15.4%), P = 0.014. Girls with TT progressed through puberty normally when evaluated using puberty nomograms. Reproductive hormones and growth velocity were lower at the first (transient) thelarche than the second (permanent) thelarche.Conclusion: TT is a frequent phenomenon that appears to be a peripheral occurrence independent of central puberty. It does not appear to affect subsequent pubertal progression as evaluated by our new puberty nomograms.
KW - Journal Article
U2 - 10.1210/jc.2016-2871
DO - 10.1210/jc.2016-2871
M3 - Journal article
C2 - 28009526
VL - 102
SP - 1001
EP - 1008
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 3
ER -
ID: 176953492