Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure. / Schjorring, Olav L.; Klitgaard, Thomas L.; Perner, Anders; Wetterslev, Jorn; Lange, Theis; Siegemund, Martin; Backlund, Minna; Keus, Frederik; Laake, Jon H.; Morgan, Matthew; Thormar, Katrin M.; Rosborg, Soren A.; Bisgaard, Jannie; Erntgaard, Annette E. S.; Lynnerup, Anne-Sofie H.; Pedersen, Rasmus L.; Crescioli, Elena; Gielstrup, Theis C.; Behzadi, Meike T.; Poulsen, Lone M.; Estrup, Stine; Laigaard, Jens P.; Andersen, Cheme; Mortensen, Camilla B.; Brand, Bjorn A.; White, Jonathan; Jarnvig, Inge-Lise; Møller, Morten H.; Quist, Lars; Bestle, Morten H.; Schonemann-Lund, Martin; Kamper, Maj K.; Hindborg, Mathias; Hollinger, Alexa; Gebhard, Caroline E.; Zellweger, Nuria; Meyhoff, Christian S.; Hjort, Mathias; Bech, Laura K.; Grofte, Thorbjorn; Bundgaard, Helle; Ostergaard, Lars H. M.; Thyo, Maria A.; Hildebrandt, Thomas; Uslu, Bulent; Solling, Christoffer G.; Pedersen, Ulf G.; Andreasen, Anne S.; Kjaer, Maj-Brit N.; Rasmussen, Bodil S.; HOT-ICU Investigators.

In: New England Journal of Medicine, Vol. 384, No. 14, 2021, p. 1301-1311.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Schjorring, OL, Klitgaard, TL, Perner, A, Wetterslev, J, Lange, T, Siegemund, M, Backlund, M, Keus, F, Laake, JH, Morgan, M, Thormar, KM, Rosborg, SA, Bisgaard, J, Erntgaard, AES, Lynnerup, A-SH, Pedersen, RL, Crescioli, E, Gielstrup, TC, Behzadi, MT, Poulsen, LM, Estrup, S, Laigaard, JP, Andersen, C, Mortensen, CB, Brand, BA, White, J, Jarnvig, I-L, Møller, MH, Quist, L, Bestle, MH, Schonemann-Lund, M, Kamper, MK, Hindborg, M, Hollinger, A, Gebhard, CE, Zellweger, N, Meyhoff, CS, Hjort, M, Bech, LK, Grofte, T, Bundgaard, H, Ostergaard, LHM, Thyo, MA, Hildebrandt, T, Uslu, B, Solling, CG, Pedersen, UG, Andreasen, AS, Kjaer, M-BN, Rasmussen, BS & HOT-ICU Investigators 2021, 'Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure', New England Journal of Medicine, vol. 384, no. 14, pp. 1301-1311. https://doi.org/10.1056/NEJMoa2032510

APA

Schjorring, O. L., Klitgaard, T. L., Perner, A., Wetterslev, J., Lange, T., Siegemund, M., Backlund, M., Keus, F., Laake, J. H., Morgan, M., Thormar, K. M., Rosborg, S. A., Bisgaard, J., Erntgaard, A. E. S., Lynnerup, A-S. H., Pedersen, R. L., Crescioli, E., Gielstrup, T. C., Behzadi, M. T., ... HOT-ICU Investigators (2021). Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure. New England Journal of Medicine, 384(14), 1301-1311. https://doi.org/10.1056/NEJMoa2032510

Vancouver

Schjorring OL, Klitgaard TL, Perner A, Wetterslev J, Lange T, Siegemund M et al. Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure. New England Journal of Medicine. 2021;384(14):1301-1311. https://doi.org/10.1056/NEJMoa2032510

Author

Schjorring, Olav L. ; Klitgaard, Thomas L. ; Perner, Anders ; Wetterslev, Jorn ; Lange, Theis ; Siegemund, Martin ; Backlund, Minna ; Keus, Frederik ; Laake, Jon H. ; Morgan, Matthew ; Thormar, Katrin M. ; Rosborg, Soren A. ; Bisgaard, Jannie ; Erntgaard, Annette E. S. ; Lynnerup, Anne-Sofie H. ; Pedersen, Rasmus L. ; Crescioli, Elena ; Gielstrup, Theis C. ; Behzadi, Meike T. ; Poulsen, Lone M. ; Estrup, Stine ; Laigaard, Jens P. ; Andersen, Cheme ; Mortensen, Camilla B. ; Brand, Bjorn A. ; White, Jonathan ; Jarnvig, Inge-Lise ; Møller, Morten H. ; Quist, Lars ; Bestle, Morten H. ; Schonemann-Lund, Martin ; Kamper, Maj K. ; Hindborg, Mathias ; Hollinger, Alexa ; Gebhard, Caroline E. ; Zellweger, Nuria ; Meyhoff, Christian S. ; Hjort, Mathias ; Bech, Laura K. ; Grofte, Thorbjorn ; Bundgaard, Helle ; Ostergaard, Lars H. M. ; Thyo, Maria A. ; Hildebrandt, Thomas ; Uslu, Bulent ; Solling, Christoffer G. ; Pedersen, Ulf G. ; Andreasen, Anne S. ; Kjaer, Maj-Brit N. ; Rasmussen, Bodil S. ; HOT-ICU Investigators. / Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure. In: New England Journal of Medicine. 2021 ; Vol. 384, No. 14. pp. 1301-1311.

Bibtex

@article{9739bd997de74ff9b169508efaa5d5f0,
title = "Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure",
abstract = "BACKGROUNDPatients with acute hypoxemic respiratory failure in the intensive care unit (ICU) are treated with supplemental oxygen, but the benefits and harms of different oxygenation targets are unclear. We hypothesized that using a lower target for partial pressure of arterial oxygen (Pao(2)) would result in lower mortality than using a higher target.METHODSIn this multicenter trial, we randomly assigned 2928 adult patients who had recently been admitted to the ICU (RESULTSAt 90 days, 618 of 1441 patients (42.9%) in the lower-oxygenation group and 613 of 1447 patients (42.4%) in the higher-oxygenation group had died (adjusted risk ratio, 1.02; 95% confidence interval, 0.94 to 1.11; P=0.64). At 90 days, there was no significant between-group difference in the percentage of days that patients were alive without life support or in the percentage of days they were alive after hospital discharge. The percentages of patients who had new episodes of shock, myocardial ischemia, ischemic stroke, or intestinal ischemia were similar in the two groups (P=0.24).CONCLUSIONSAmong adult patients with acute hypoxemic respiratory failure in the ICU, a lower oxygenation target did not result in lower mortality than a higher target at 90 days.",
author = "Schjorring, {Olav L.} and Klitgaard, {Thomas L.} and Anders Perner and Jorn Wetterslev and Theis Lange and Martin Siegemund and Minna Backlund and Frederik Keus and Laake, {Jon H.} and Matthew Morgan and Thormar, {Katrin M.} and Rosborg, {Soren A.} and Jannie Bisgaard and Erntgaard, {Annette E. S.} and Lynnerup, {Anne-Sofie H.} and Pedersen, {Rasmus L.} and Elena Crescioli and Gielstrup, {Theis C.} and Behzadi, {Meike T.} and Poulsen, {Lone M.} and Stine Estrup and Laigaard, {Jens P.} and Cheme Andersen and Mortensen, {Camilla B.} and Brand, {Bjorn A.} and Jonathan White and Inge-Lise Jarnvig and M{\o}ller, {Morten H.} and Lars Quist and Bestle, {Morten H.} and Martin Schonemann-Lund and Kamper, {Maj K.} and Mathias Hindborg and Alexa Hollinger and Gebhard, {Caroline E.} and Nuria Zellweger and Meyhoff, {Christian S.} and Mathias Hjort and Bech, {Laura K.} and Thorbjorn Grofte and Helle Bundgaard and Ostergaard, {Lars H. M.} and Thyo, {Maria A.} and Thomas Hildebrandt and Bulent Uslu and Solling, {Christoffer G.} and Pedersen, {Ulf G.} and Andreasen, {Anne S.} and Kjaer, {Maj-Brit N.} and Rasmussen, {Bodil S.} and {HOT-ICU Investigators}",
year = "2021",
doi = "10.1056/NEJMoa2032510",
language = "English",
volume = "384",
pages = "1301--1311",
journal = "New England Journal of Medicine",
issn = "0028-4793",
publisher = "Massachusetts Medical Society",
number = "14",

}

RIS

TY - JOUR

T1 - Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure

AU - Schjorring, Olav L.

AU - Klitgaard, Thomas L.

AU - Perner, Anders

AU - Wetterslev, Jorn

AU - Lange, Theis

AU - Siegemund, Martin

AU - Backlund, Minna

AU - Keus, Frederik

AU - Laake, Jon H.

AU - Morgan, Matthew

AU - Thormar, Katrin M.

AU - Rosborg, Soren A.

AU - Bisgaard, Jannie

AU - Erntgaard, Annette E. S.

AU - Lynnerup, Anne-Sofie H.

AU - Pedersen, Rasmus L.

AU - Crescioli, Elena

AU - Gielstrup, Theis C.

AU - Behzadi, Meike T.

AU - Poulsen, Lone M.

AU - Estrup, Stine

AU - Laigaard, Jens P.

AU - Andersen, Cheme

AU - Mortensen, Camilla B.

AU - Brand, Bjorn A.

AU - White, Jonathan

AU - Jarnvig, Inge-Lise

AU - Møller, Morten H.

AU - Quist, Lars

AU - Bestle, Morten H.

AU - Schonemann-Lund, Martin

AU - Kamper, Maj K.

AU - Hindborg, Mathias

AU - Hollinger, Alexa

AU - Gebhard, Caroline E.

AU - Zellweger, Nuria

AU - Meyhoff, Christian S.

AU - Hjort, Mathias

AU - Bech, Laura K.

AU - Grofte, Thorbjorn

AU - Bundgaard, Helle

AU - Ostergaard, Lars H. M.

AU - Thyo, Maria A.

AU - Hildebrandt, Thomas

AU - Uslu, Bulent

AU - Solling, Christoffer G.

AU - Pedersen, Ulf G.

AU - Andreasen, Anne S.

AU - Kjaer, Maj-Brit N.

AU - Rasmussen, Bodil S.

AU - HOT-ICU Investigators

PY - 2021

Y1 - 2021

N2 - BACKGROUNDPatients with acute hypoxemic respiratory failure in the intensive care unit (ICU) are treated with supplemental oxygen, but the benefits and harms of different oxygenation targets are unclear. We hypothesized that using a lower target for partial pressure of arterial oxygen (Pao(2)) would result in lower mortality than using a higher target.METHODSIn this multicenter trial, we randomly assigned 2928 adult patients who had recently been admitted to the ICU (RESULTSAt 90 days, 618 of 1441 patients (42.9%) in the lower-oxygenation group and 613 of 1447 patients (42.4%) in the higher-oxygenation group had died (adjusted risk ratio, 1.02; 95% confidence interval, 0.94 to 1.11; P=0.64). At 90 days, there was no significant between-group difference in the percentage of days that patients were alive without life support or in the percentage of days they were alive after hospital discharge. The percentages of patients who had new episodes of shock, myocardial ischemia, ischemic stroke, or intestinal ischemia were similar in the two groups (P=0.24).CONCLUSIONSAmong adult patients with acute hypoxemic respiratory failure in the ICU, a lower oxygenation target did not result in lower mortality than a higher target at 90 days.

AB - BACKGROUNDPatients with acute hypoxemic respiratory failure in the intensive care unit (ICU) are treated with supplemental oxygen, but the benefits and harms of different oxygenation targets are unclear. We hypothesized that using a lower target for partial pressure of arterial oxygen (Pao(2)) would result in lower mortality than using a higher target.METHODSIn this multicenter trial, we randomly assigned 2928 adult patients who had recently been admitted to the ICU (RESULTSAt 90 days, 618 of 1441 patients (42.9%) in the lower-oxygenation group and 613 of 1447 patients (42.4%) in the higher-oxygenation group had died (adjusted risk ratio, 1.02; 95% confidence interval, 0.94 to 1.11; P=0.64). At 90 days, there was no significant between-group difference in the percentage of days that patients were alive without life support or in the percentage of days they were alive after hospital discharge. The percentages of patients who had new episodes of shock, myocardial ischemia, ischemic stroke, or intestinal ischemia were similar in the two groups (P=0.24).CONCLUSIONSAmong adult patients with acute hypoxemic respiratory failure in the ICU, a lower oxygenation target did not result in lower mortality than a higher target at 90 days.

U2 - 10.1056/NEJMoa2032510

DO - 10.1056/NEJMoa2032510

M3 - Journal article

C2 - 33471452

VL - 384

SP - 1301

EP - 1311

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 0028-4793

IS - 14

ER -

ID: 260089585