Early initiated postoperative rehabilitation enhances quality of life in patients with operable lung cancer: Secondary outcomes from a randomized trial
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Early initiated postoperative rehabilitation enhances quality of life in patients with operable lung cancer : Secondary outcomes from a randomized trial. / Sommer, Maja Schick; Vibe-Petersen, Jette; Staerkind, Maja Bohlbro; Langer, Seppo W.; Larsen, Klaus Richter; Trier, Karen; Christensen, Merete; Clementsen, Paul F.; Missel, Malene; Christensen, Karl Bang; Lillelund, Christian; Langberg, Henning; Pedersen, Jesper H.; Quist, Morten.
In: Lung Cancer, Vol. 146, 2020, p. 285-289.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Early initiated postoperative rehabilitation enhances quality of life in patients with operable lung cancer
T2 - Secondary outcomes from a randomized trial
AU - Sommer, Maja Schick
AU - Vibe-Petersen, Jette
AU - Staerkind, Maja Bohlbro
AU - Langer, Seppo W.
AU - Larsen, Klaus Richter
AU - Trier, Karen
AU - Christensen, Merete
AU - Clementsen, Paul F.
AU - Missel, Malene
AU - Christensen, Karl Bang
AU - Lillelund, Christian
AU - Langberg, Henning
AU - Pedersen, Jesper H.
AU - Quist, Morten
PY - 2020
Y1 - 2020
N2 - Introduction: Patients with lung cancer report a lower degree of Health Related Quality of Life (HRQoL) compared with other cancer patients. HRQoL reflects how patients experience the impact of their disease and its treatment on their quality of daily living. A widely used questionnaire in lung cancer patients is the Functional Assessment of Cancer Therapy - Lung (FACT-L) questionnaire. Here we report the secondary outcomes on FACT-L data from the Postoperative Rehabilitation in Operation for Lung CAncer (PROLUCA) study, which describes the effect of early (14 days) versus late initiated (14 weeks) postoperative rehabilitation.Materials and methods: The PROLUCA study was designed as a two-armed randomized controlled trial with an early rehabilitation group (14 days after surgery (ERG)) or a control arm with a late rehabilitation group (14 weeks after surgery (LRG)). The results for seven domain scores obtained using the FACT-L at the following time-points: baseline, 14 weeks, 26 weeks and 52 weeks after surgery are presented here.Results: 119 patients were randomized to the ERG and 116 to the LRG. In the ERG, HRQoL measured by both FACT-L and FACT-G (general core instrument) showed a continuous improvement up to 26 weeks after which HRQoL decreased after further 26 weeks without structured intervention. In the LRG a non-significant deterioration was detected over the first 14 weeks after surgery. After participation in the 12 weeks rehabilitation program, an increase in HRQoL was seen, without reaching the same level as the early group.Conclusion: Analyses of the seven domain scores obtained using FACT-L and FACT-G reflect the importance of starting exercise early after surgery since the ERG avoid a temporary decrease in HRQoL. It is therefore recommended to start up a structured rehabilitation program 14 days after surgery, containing high intensity interval training and strength exercise twice a week for 12 weeks.
AB - Introduction: Patients with lung cancer report a lower degree of Health Related Quality of Life (HRQoL) compared with other cancer patients. HRQoL reflects how patients experience the impact of their disease and its treatment on their quality of daily living. A widely used questionnaire in lung cancer patients is the Functional Assessment of Cancer Therapy - Lung (FACT-L) questionnaire. Here we report the secondary outcomes on FACT-L data from the Postoperative Rehabilitation in Operation for Lung CAncer (PROLUCA) study, which describes the effect of early (14 days) versus late initiated (14 weeks) postoperative rehabilitation.Materials and methods: The PROLUCA study was designed as a two-armed randomized controlled trial with an early rehabilitation group (14 days after surgery (ERG)) or a control arm with a late rehabilitation group (14 weeks after surgery (LRG)). The results for seven domain scores obtained using the FACT-L at the following time-points: baseline, 14 weeks, 26 weeks and 52 weeks after surgery are presented here.Results: 119 patients were randomized to the ERG and 116 to the LRG. In the ERG, HRQoL measured by both FACT-L and FACT-G (general core instrument) showed a continuous improvement up to 26 weeks after which HRQoL decreased after further 26 weeks without structured intervention. In the LRG a non-significant deterioration was detected over the first 14 weeks after surgery. After participation in the 12 weeks rehabilitation program, an increase in HRQoL was seen, without reaching the same level as the early group.Conclusion: Analyses of the seven domain scores obtained using FACT-L and FACT-G reflect the importance of starting exercise early after surgery since the ERG avoid a temporary decrease in HRQoL. It is therefore recommended to start up a structured rehabilitation program 14 days after surgery, containing high intensity interval training and strength exercise twice a week for 12 weeks.
KW - Lung cancer
KW - Postoperative exercise
KW - Functional assessment of cancer therapy
KW - Health related quality of life
KW - Rehabilitation
KW - SURGERY
KW - THERAPY
U2 - 10.1016/j.lungcan.2020.06.023
DO - 10.1016/j.lungcan.2020.06.023
M3 - Journal article
C2 - 32593918
VL - 146
SP - 285
EP - 289
JO - Lung Cancer
JF - Lung Cancer
SN - 0169-5002
ER -
ID: 245708973