Changing genetic architecture of body mass index from infancy to early adulthood: an individual based pooled analysis of 25 twin cohorts

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Changing genetic architecture of body mass index from infancy to early adulthood : an individual based pooled analysis of 25 twin cohorts. / Silventoinen, Karri; Li, Weilong; Jelenkovic, Aline; Sund, Reijo; Yokoyama, Yoshie; Aaltonen, Sari; Piirtola, Maarit; Sugawara, Masumi; Tanaka, Mami; Matsumoto, Satoko; Baker, Laura A.; Tuvblad, Catherine; Tynelius, Per; Rasmussen, Finn; Craig, Jeffrey M.; Saffery, Richard; Willemsen, Gonneke; Bartels, Meike; van Beijsterveldt, Catharina E. M.; Martin, Nicholas G.; Medland, Sarah E.; Montgomery, Grant W.; Lichtenstein, Paul; Krueger, Robert F.; McGue, Matt; Pahlen, Shandell; Christensen, Kaare; Skytthe, Axel; Kyvik, Kirsten O.; Saudino, Kimberly J.; Dubois, Lise; Boivin, Michel; Brendgen, Mara; Dionne, Ginette; Vitaro, Frank; Ullemar, Vilhelmina; Almqvist, Catarina; Magnusson, Patrik K. E.; Corley, Robin P.; Huibregtse, Brooke M.; Knafo-Noam, Ariel; Mankuta, David; Abramson, Lior; Haworth, Claire M. A.; Plomin, Robert; Bjerregaard-Andersen, Morten; Beck-Nielsen, Henning; Sodemann, Morten; Duncan, Glen E.; Buchwald, Dedra; Burt, S. Alexandra; Klump, Kelly L.; Llewellyn, Clare H.; Fisher, Abigail; Boomsma, Dorret; Sorensen, Thorkild I. A.; Kaprio, Jaakko.

In: International Journal of Obesity, Vol. 46, 2022, p. 1901–1909.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Silventoinen, K, Li, W, Jelenkovic, A, Sund, R, Yokoyama, Y, Aaltonen, S, Piirtola, M, Sugawara, M, Tanaka, M, Matsumoto, S, Baker, LA, Tuvblad, C, Tynelius, P, Rasmussen, F, Craig, JM, Saffery, R, Willemsen, G, Bartels, M, van Beijsterveldt, CEM, Martin, NG, Medland, SE, Montgomery, GW, Lichtenstein, P, Krueger, RF, McGue, M, Pahlen, S, Christensen, K, Skytthe, A, Kyvik, KO, Saudino, KJ, Dubois, L, Boivin, M, Brendgen, M, Dionne, G, Vitaro, F, Ullemar, V, Almqvist, C, Magnusson, PKE, Corley, RP, Huibregtse, BM, Knafo-Noam, A, Mankuta, D, Abramson, L, Haworth, CMA, Plomin, R, Bjerregaard-Andersen, M, Beck-Nielsen, H, Sodemann, M, Duncan, GE, Buchwald, D, Burt, SA, Klump, KL, Llewellyn, CH, Fisher, A, Boomsma, D, Sorensen, TIA & Kaprio, J 2022, 'Changing genetic architecture of body mass index from infancy to early adulthood: an individual based pooled analysis of 25 twin cohorts', International Journal of Obesity, vol. 46, pp. 1901–1909. https://doi.org/10.1038/s41366-022-01202-3

APA

Silventoinen, K., Li, W., Jelenkovic, A., Sund, R., Yokoyama, Y., Aaltonen, S., Piirtola, M., Sugawara, M., Tanaka, M., Matsumoto, S., Baker, L. A., Tuvblad, C., Tynelius, P., Rasmussen, F., Craig, J. M., Saffery, R., Willemsen, G., Bartels, M., van Beijsterveldt, C. E. M., ... Kaprio, J. (2022). Changing genetic architecture of body mass index from infancy to early adulthood: an individual based pooled analysis of 25 twin cohorts. International Journal of Obesity, 46, 1901–1909. https://doi.org/10.1038/s41366-022-01202-3

Vancouver

Silventoinen K, Li W, Jelenkovic A, Sund R, Yokoyama Y, Aaltonen S et al. Changing genetic architecture of body mass index from infancy to early adulthood: an individual based pooled analysis of 25 twin cohorts. International Journal of Obesity. 2022;46:1901–1909. https://doi.org/10.1038/s41366-022-01202-3

Author

Silventoinen, Karri ; Li, Weilong ; Jelenkovic, Aline ; Sund, Reijo ; Yokoyama, Yoshie ; Aaltonen, Sari ; Piirtola, Maarit ; Sugawara, Masumi ; Tanaka, Mami ; Matsumoto, Satoko ; Baker, Laura A. ; Tuvblad, Catherine ; Tynelius, Per ; Rasmussen, Finn ; Craig, Jeffrey M. ; Saffery, Richard ; Willemsen, Gonneke ; Bartels, Meike ; van Beijsterveldt, Catharina E. M. ; Martin, Nicholas G. ; Medland, Sarah E. ; Montgomery, Grant W. ; Lichtenstein, Paul ; Krueger, Robert F. ; McGue, Matt ; Pahlen, Shandell ; Christensen, Kaare ; Skytthe, Axel ; Kyvik, Kirsten O. ; Saudino, Kimberly J. ; Dubois, Lise ; Boivin, Michel ; Brendgen, Mara ; Dionne, Ginette ; Vitaro, Frank ; Ullemar, Vilhelmina ; Almqvist, Catarina ; Magnusson, Patrik K. E. ; Corley, Robin P. ; Huibregtse, Brooke M. ; Knafo-Noam, Ariel ; Mankuta, David ; Abramson, Lior ; Haworth, Claire M. A. ; Plomin, Robert ; Bjerregaard-Andersen, Morten ; Beck-Nielsen, Henning ; Sodemann, Morten ; Duncan, Glen E. ; Buchwald, Dedra ; Burt, S. Alexandra ; Klump, Kelly L. ; Llewellyn, Clare H. ; Fisher, Abigail ; Boomsma, Dorret ; Sorensen, Thorkild I. A. ; Kaprio, Jaakko. / Changing genetic architecture of body mass index from infancy to early adulthood : an individual based pooled analysis of 25 twin cohorts. In: International Journal of Obesity. 2022 ; Vol. 46. pp. 1901–1909.

Bibtex

@article{00346e8b34df4e4ba46e47181e3960f2,
title = "Changing genetic architecture of body mass index from infancy to early adulthood: an individual based pooled analysis of 25 twin cohorts",
abstract = "Background Body mass index (BMI) shows strong continuity over childhood and adolescence and high childhood BMI is the strongest predictor of adult obesity. Genetic factors strongly contribute to this continuity, but it is still poorly known how their contribution changes over childhood and adolescence. Thus, we used the genetic twin design to estimate the genetic correlations of BMI from infancy to adulthood and compared them to the genetic correlations of height. Methods We pooled individual level data from 25 longitudinal twin cohorts including 38,530 complete twin pairs and having 283,766 longitudinal height and weight measures. The data were analyzed using Cholesky decomposition offering genetic and environmental correlations of BMI and height between all age combinations from 1 to 19 years of age. Results The genetic correlations of BMI and height were stronger than the trait correlations. For BMI, we found that genetic correlations decreased as the age between the assessments increased, a trend that was especially visible from early to middle childhood. In contrast, for height, the genetic correlations were strong between all ages. Age-to-age correlations between environmental factors shared by co-twins were found for BMI in early childhood but disappeared altogether by middle childhood. For height, shared environmental correlations persisted from infancy to adulthood. Conclusions Our results suggest that the genes affecting BMI change over childhood and adolescence leading to decreasing age-to-age genetic correlations. This change is especially visible from early to middle childhood indicating that new genetic factors start to affect BMI in middle childhood. Identifying mediating pathways of these genetic factors can open possibilities for interventions, especially for those children with high genetic predisposition to adult obesity.",
keywords = "ANTHROPOMETRICAL MEASURES, ENVIRONMENTAL VARIATION, COLLABORATIVE PROJECT, METABOLIC SYNDROME, CHILDHOOD, OBESITY, AGE, WEIGHT, BMI, HEIGHT",
author = "Karri Silventoinen and Weilong Li and Aline Jelenkovic and Reijo Sund and Yoshie Yokoyama and Sari Aaltonen and Maarit Piirtola and Masumi Sugawara and Mami Tanaka and Satoko Matsumoto and Baker, {Laura A.} and Catherine Tuvblad and Per Tynelius and Finn Rasmussen and Craig, {Jeffrey M.} and Richard Saffery and Gonneke Willemsen and Meike Bartels and {van Beijsterveldt}, {Catharina E. M.} and Martin, {Nicholas G.} and Medland, {Sarah E.} and Montgomery, {Grant W.} and Paul Lichtenstein and Krueger, {Robert F.} and Matt McGue and Shandell Pahlen and Kaare Christensen and Axel Skytthe and Kyvik, {Kirsten O.} and Saudino, {Kimberly J.} and Lise Dubois and Michel Boivin and Mara Brendgen and Ginette Dionne and Frank Vitaro and Vilhelmina Ullemar and Catarina Almqvist and Magnusson, {Patrik K. E.} and Corley, {Robin P.} and Huibregtse, {Brooke M.} and Ariel Knafo-Noam and David Mankuta and Lior Abramson and Haworth, {Claire M. A.} and Robert Plomin and Morten Bjerregaard-Andersen and Henning Beck-Nielsen and Morten Sodemann and Duncan, {Glen E.} and Dedra Buchwald and Burt, {S. Alexandra} and Klump, {Kelly L.} and Llewellyn, {Clare H.} and Abigail Fisher and Dorret Boomsma and Sorensen, {Thorkild I. A.} and Jaakko Kaprio",
year = "2022",
doi = "10.1038/s41366-022-01202-3",
language = "English",
volume = "46",
pages = "1901–1909",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Changing genetic architecture of body mass index from infancy to early adulthood

T2 - an individual based pooled analysis of 25 twin cohorts

AU - Silventoinen, Karri

AU - Li, Weilong

AU - Jelenkovic, Aline

AU - Sund, Reijo

AU - Yokoyama, Yoshie

AU - Aaltonen, Sari

AU - Piirtola, Maarit

AU - Sugawara, Masumi

AU - Tanaka, Mami

AU - Matsumoto, Satoko

AU - Baker, Laura A.

AU - Tuvblad, Catherine

AU - Tynelius, Per

AU - Rasmussen, Finn

AU - Craig, Jeffrey M.

AU - Saffery, Richard

AU - Willemsen, Gonneke

AU - Bartels, Meike

AU - van Beijsterveldt, Catharina E. M.

AU - Martin, Nicholas G.

AU - Medland, Sarah E.

AU - Montgomery, Grant W.

AU - Lichtenstein, Paul

AU - Krueger, Robert F.

AU - McGue, Matt

AU - Pahlen, Shandell

AU - Christensen, Kaare

AU - Skytthe, Axel

AU - Kyvik, Kirsten O.

AU - Saudino, Kimberly J.

AU - Dubois, Lise

AU - Boivin, Michel

AU - Brendgen, Mara

AU - Dionne, Ginette

AU - Vitaro, Frank

AU - Ullemar, Vilhelmina

AU - Almqvist, Catarina

AU - Magnusson, Patrik K. E.

AU - Corley, Robin P.

AU - Huibregtse, Brooke M.

AU - Knafo-Noam, Ariel

AU - Mankuta, David

AU - Abramson, Lior

AU - Haworth, Claire M. A.

AU - Plomin, Robert

AU - Bjerregaard-Andersen, Morten

AU - Beck-Nielsen, Henning

AU - Sodemann, Morten

AU - Duncan, Glen E.

AU - Buchwald, Dedra

AU - Burt, S. Alexandra

AU - Klump, Kelly L.

AU - Llewellyn, Clare H.

AU - Fisher, Abigail

AU - Boomsma, Dorret

AU - Sorensen, Thorkild I. A.

AU - Kaprio, Jaakko

PY - 2022

Y1 - 2022

N2 - Background Body mass index (BMI) shows strong continuity over childhood and adolescence and high childhood BMI is the strongest predictor of adult obesity. Genetic factors strongly contribute to this continuity, but it is still poorly known how their contribution changes over childhood and adolescence. Thus, we used the genetic twin design to estimate the genetic correlations of BMI from infancy to adulthood and compared them to the genetic correlations of height. Methods We pooled individual level data from 25 longitudinal twin cohorts including 38,530 complete twin pairs and having 283,766 longitudinal height and weight measures. The data were analyzed using Cholesky decomposition offering genetic and environmental correlations of BMI and height between all age combinations from 1 to 19 years of age. Results The genetic correlations of BMI and height were stronger than the trait correlations. For BMI, we found that genetic correlations decreased as the age between the assessments increased, a trend that was especially visible from early to middle childhood. In contrast, for height, the genetic correlations were strong between all ages. Age-to-age correlations between environmental factors shared by co-twins were found for BMI in early childhood but disappeared altogether by middle childhood. For height, shared environmental correlations persisted from infancy to adulthood. Conclusions Our results suggest that the genes affecting BMI change over childhood and adolescence leading to decreasing age-to-age genetic correlations. This change is especially visible from early to middle childhood indicating that new genetic factors start to affect BMI in middle childhood. Identifying mediating pathways of these genetic factors can open possibilities for interventions, especially for those children with high genetic predisposition to adult obesity.

AB - Background Body mass index (BMI) shows strong continuity over childhood and adolescence and high childhood BMI is the strongest predictor of adult obesity. Genetic factors strongly contribute to this continuity, but it is still poorly known how their contribution changes over childhood and adolescence. Thus, we used the genetic twin design to estimate the genetic correlations of BMI from infancy to adulthood and compared them to the genetic correlations of height. Methods We pooled individual level data from 25 longitudinal twin cohorts including 38,530 complete twin pairs and having 283,766 longitudinal height and weight measures. The data were analyzed using Cholesky decomposition offering genetic and environmental correlations of BMI and height between all age combinations from 1 to 19 years of age. Results The genetic correlations of BMI and height were stronger than the trait correlations. For BMI, we found that genetic correlations decreased as the age between the assessments increased, a trend that was especially visible from early to middle childhood. In contrast, for height, the genetic correlations were strong between all ages. Age-to-age correlations between environmental factors shared by co-twins were found for BMI in early childhood but disappeared altogether by middle childhood. For height, shared environmental correlations persisted from infancy to adulthood. Conclusions Our results suggest that the genes affecting BMI change over childhood and adolescence leading to decreasing age-to-age genetic correlations. This change is especially visible from early to middle childhood indicating that new genetic factors start to affect BMI in middle childhood. Identifying mediating pathways of these genetic factors can open possibilities for interventions, especially for those children with high genetic predisposition to adult obesity.

KW - ANTHROPOMETRICAL MEASURES

KW - ENVIRONMENTAL VARIATION

KW - COLLABORATIVE PROJECT

KW - METABOLIC SYNDROME

KW - CHILDHOOD

KW - OBESITY

KW - AGE

KW - WEIGHT

KW - BMI

KW - HEIGHT

U2 - 10.1038/s41366-022-01202-3

DO - 10.1038/s41366-022-01202-3

M3 - Journal article

C2 - 35945263

VL - 46

SP - 1901

EP - 1909

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

ER -

ID: 317510127