Standard
Changes in Anti-Müllerian Hormone (AMH) throughout the Life Span: A Population-Based Study of 1027 Healthy Males from Birth (Cord Blood) to the Age of 69 Years. / Aksglæde, Lise; Sørensen, K; Boas, Malene; Mouritsen, Anne Kristine Munk; Hagen, CP; Jensen, RB; Petersen, JH; Linneberg, A; Andersson, AM; Main, KM; Skakkebæk, Niels Erik; Juul, A.
In:
Journal of Clinical Endocrinology and Metabolism, Vol. 95, No. 12, 2010, p. 5357-5364.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Aksglæde, L, Sørensen, K, Boas, M, Mouritsen, AKM, Hagen, CP, Jensen, RB
, Petersen, JH, Linneberg, A, Andersson, AM
, Main, KM, Skakkebæk, NE & Juul, A 2010, '
Changes in Anti-Müllerian Hormone (AMH) throughout the Life Span: A Population-Based Study of 1027 Healthy Males from Birth (Cord Blood) to the Age of 69 Years',
Journal of Clinical Endocrinology and Metabolism, vol. 95, no. 12, pp. 5357-5364. <
http://ovidsp.uk.ovid.com.ep.fjernadgang.kb.dk/sp-3.4.1b/ovidweb.cgi?WebLinkFrameset=1&S=NGIGPDMOOPHFEPKKFNBLGBPFMIENAA00&returnUrl=ovidweb.cgi%3f%26TOC%3dS.sh.15.16.19.22%257c34%257c50%26FORMAT%3dtoc%26FIELDS%3dTOC%26S%3dNGIGPDMOOPHFEPKKFNBLGBPFMIENAA00&directlink=http%3a%2f%2fgraphics.uk.ovid.com%2fovftpdfs%2fPDHFFNPFGBKKOP00%2ffs046%2fovft%2flive%2fgv023%2f00004678%2f00004678-201012000-00034.pdf&filename=Changes+in+Anti-Mullerian+Hormone+%28AMH%29+throughout+the+Life+Span%3a+A+Population-Based+Study+of+1027+Healthy+Males+from+Birth+%28Cord+Blood%29+to+the+Age+of+69+Years.&link_from=S.sh.15.16.19.22%7c34&pdf_key=B&pdf_index=S.sh.15.16.19.22>
APA
Aksglæde, L., Sørensen, K., Boas, M., Mouritsen, A. K. M., Hagen, CP., Jensen, RB.
, Petersen, JH., Linneberg, A., Andersson, AM.
, Main, KM., Skakkebæk, N. E., & Juul, A. (2010).
Changes in Anti-Müllerian Hormone (AMH) throughout the Life Span: A Population-Based Study of 1027 Healthy Males from Birth (Cord Blood) to the Age of 69 Years.
Journal of Clinical Endocrinology and Metabolism,
95(12), 5357-5364.
http://ovidsp.uk.ovid.com.ep.fjernadgang.kb.dk/sp-3.4.1b/ovidweb.cgi?WebLinkFrameset=1&S=NGIGPDMOOPHFEPKKFNBLGBPFMIENAA00&returnUrl=ovidweb.cgi%3f%26TOC%3dS.sh.15.16.19.22%257c34%257c50%26FORMAT%3dtoc%26FIELDS%3dTOC%26S%3dNGIGPDMOOPHFEPKKFNBLGBPFMIENAA00&directlink=http%3a%2f%2fgraphics.uk.ovid.com%2fovftpdfs%2fPDHFFNPFGBKKOP00%2ffs046%2fovft%2flive%2fgv023%2f00004678%2f00004678-201012000-00034.pdf&filename=Changes+in+Anti-Mullerian+Hormone+%28AMH%29+throughout+the+Life+Span%3a+A+Population-Based+Study+of+1027+Healthy+Males+from+Birth+%28Cord+Blood%29+to+the+Age+of+69+Years.&link_from=S.sh.15.16.19.22%7c34&pdf_key=B&pdf_index=S.sh.15.16.19.22Vancouver
Aksglæde L, Sørensen K, Boas M, Mouritsen AKM, Hagen CP, Jensen RB et al. Changes in Anti-Müllerian Hormone (AMH) throughout the Life Span: A Population-Based Study of 1027 Healthy Males from Birth (Cord Blood) to the Age of 69 Years. Journal of Clinical Endocrinology and Metabolism. 2010;95(12):5357-5364.
Author
Aksglæde, Lise ; Sørensen, K ; Boas, Malene ; Mouritsen, Anne Kristine Munk ; Hagen, CP ; Jensen, RB ; Petersen, JH ; Linneberg, A ; Andersson, AM ; Main, KM ; Skakkebæk, Niels Erik ; Juul, A. / Changes in Anti-Müllerian Hormone (AMH) throughout the Life Span: A Population-Based Study of 1027 Healthy Males from Birth (Cord Blood) to the Age of 69 Years. In: Journal of Clinical Endocrinology and Metabolism. 2010 ; Vol. 95, No. 12. pp. 5357-5364.
Bibtex
@article{af0581370a5f4a3c962a5639a6d9374d,
title = "Changes in Anti-M{\"u}llerian Hormone (AMH) throughout the Life Span: A Population-Based Study of 1027 Healthy Males from Birth (Cord Blood) to the Age of 69 Years",
abstract = "Context: Anti-Mu¨ llerian hormone (AMH), which is secreted by immature Sertoli cells, triggers theinvolution of the fetalMu¨ llerian ducts.AMHis a testis-specific marker used for diagnosis in infantswith ambiguous genitalia or bilateral cryptorchidism.Aim: The aim of the study was to describe the ontogeny of AMH secretion through life in healthy males.Setting:This was a population-based study of healthy volunteers.Participants: Participants included 1027 healthy males from birth (cord blood) to 69 yr. A subgroupwas followed up longitudinally through the infantile minipuberty [(in cord blood, and at 3 and 12months), n 55] and another group through puberty [(biannual measurements), n 83].Main Outcome Measures: Serum AMH was determined by a sensitive immunoassay. Serum testosterone,LH, and FSH were measured, and pubertal staging was performed in boys aged 6 to 20yr (n 616).Results: SerumAMHwas above the detection limit in all samples with a marked variation accordingto age and pubertal status. The median AMH level in cord blood was 148 pmol/liter and increasedsignificantly to the highest observed levels at 3 months (P 0.0001). AMH declined at 12 months(P 0.0001) and remained at a relatively stable level throughout childhood until puberty, whenAMH declined progressively with adults exhibiting 3–4% of infant levels.Conclusion: Based on this extensive data set, we found detectable AMH serum levels at all ages,with the highest measured levels during infancy. At the time of puberty, AMH concentrationsdeclined and remained relatively stable throughout adulthood. The potential physiological role ofAMH and clinical applicability of AMH measurements remain to be determined. (J Clin EndocrinolMetab 95: 5357–5364, 2010)",
author = "Lise Aksgl{\ae}de and K S{\o}rensen and Malene Boas and Mouritsen, {Anne Kristine Munk} and CP Hagen and RB Jensen and JH Petersen and A Linneberg and AM Andersson and KM Main and Skakkeb{\ae}k, {Niels Erik} and A Juul",
year = "2010",
language = "Dansk",
volume = "95",
pages = "5357--5364",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "12",
}
RIS
TY - JOUR
T1 - Changes in Anti-Müllerian Hormone (AMH) throughout the Life Span: A Population-Based Study of 1027 Healthy Males from Birth (Cord Blood) to the Age of 69 Years
AU - Aksglæde, Lise
AU - Sørensen, K
AU - Boas, Malene
AU - Mouritsen, Anne Kristine Munk
AU - Hagen, CP
AU - Jensen, RB
AU - Petersen, JH
AU - Linneberg, A
AU - Andersson, AM
AU - Main, KM
AU - Skakkebæk, Niels Erik
AU - Juul, A
PY - 2010
Y1 - 2010
N2 - Context: Anti-Mu¨ llerian hormone (AMH), which is secreted by immature Sertoli cells, triggers theinvolution of the fetalMu¨ llerian ducts.AMHis a testis-specific marker used for diagnosis in infantswith ambiguous genitalia or bilateral cryptorchidism.Aim: The aim of the study was to describe the ontogeny of AMH secretion through life in healthy males.Setting:This was a population-based study of healthy volunteers.Participants: Participants included 1027 healthy males from birth (cord blood) to 69 yr. A subgroupwas followed up longitudinally through the infantile minipuberty [(in cord blood, and at 3 and 12months), n 55] and another group through puberty [(biannual measurements), n 83].Main Outcome Measures: Serum AMH was determined by a sensitive immunoassay. Serum testosterone,LH, and FSH were measured, and pubertal staging was performed in boys aged 6 to 20yr (n 616).Results: SerumAMHwas above the detection limit in all samples with a marked variation accordingto age and pubertal status. The median AMH level in cord blood was 148 pmol/liter and increasedsignificantly to the highest observed levels at 3 months (P 0.0001). AMH declined at 12 months(P 0.0001) and remained at a relatively stable level throughout childhood until puberty, whenAMH declined progressively with adults exhibiting 3–4% of infant levels.Conclusion: Based on this extensive data set, we found detectable AMH serum levels at all ages,with the highest measured levels during infancy. At the time of puberty, AMH concentrationsdeclined and remained relatively stable throughout adulthood. The potential physiological role ofAMH and clinical applicability of AMH measurements remain to be determined. (J Clin EndocrinolMetab 95: 5357–5364, 2010)
AB - Context: Anti-Mu¨ llerian hormone (AMH), which is secreted by immature Sertoli cells, triggers theinvolution of the fetalMu¨ llerian ducts.AMHis a testis-specific marker used for diagnosis in infantswith ambiguous genitalia or bilateral cryptorchidism.Aim: The aim of the study was to describe the ontogeny of AMH secretion through life in healthy males.Setting:This was a population-based study of healthy volunteers.Participants: Participants included 1027 healthy males from birth (cord blood) to 69 yr. A subgroupwas followed up longitudinally through the infantile minipuberty [(in cord blood, and at 3 and 12months), n 55] and another group through puberty [(biannual measurements), n 83].Main Outcome Measures: Serum AMH was determined by a sensitive immunoassay. Serum testosterone,LH, and FSH were measured, and pubertal staging was performed in boys aged 6 to 20yr (n 616).Results: SerumAMHwas above the detection limit in all samples with a marked variation accordingto age and pubertal status. The median AMH level in cord blood was 148 pmol/liter and increasedsignificantly to the highest observed levels at 3 months (P 0.0001). AMH declined at 12 months(P 0.0001) and remained at a relatively stable level throughout childhood until puberty, whenAMH declined progressively with adults exhibiting 3–4% of infant levels.Conclusion: Based on this extensive data set, we found detectable AMH serum levels at all ages,with the highest measured levels during infancy. At the time of puberty, AMH concentrationsdeclined and remained relatively stable throughout adulthood. The potential physiological role ofAMH and clinical applicability of AMH measurements remain to be determined. (J Clin EndocrinolMetab 95: 5357–5364, 2010)
M3 - Tidsskriftartikel
VL - 95
SP - 5357
EP - 5364
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 12
ER -
