Body mass index in childhood and adult risk of primary liver cancer

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Body mass index in childhood and adult risk of primary liver cancer. / Berentzen, Tina Landsvig; Gamborg, Michael; Holst, Claus; Sørensen, Thorkild I A; Baker, Jennifer L.

In: Journal of Hepatology, Vol. 60, No. 2, 02.2014, p. 325-30.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Berentzen, TL, Gamborg, M, Holst, C, Sørensen, TIA & Baker, JL 2014, 'Body mass index in childhood and adult risk of primary liver cancer', Journal of Hepatology, vol. 60, no. 2, pp. 325-30. https://doi.org/10.1016/j.jhep.2013.09.015

APA

Berentzen, T. L., Gamborg, M., Holst, C., Sørensen, T. I. A., & Baker, J. L. (2014). Body mass index in childhood and adult risk of primary liver cancer. Journal of Hepatology, 60(2), 325-30. https://doi.org/10.1016/j.jhep.2013.09.015

Vancouver

Berentzen TL, Gamborg M, Holst C, Sørensen TIA, Baker JL. Body mass index in childhood and adult risk of primary liver cancer. Journal of Hepatology. 2014 Feb;60(2):325-30. https://doi.org/10.1016/j.jhep.2013.09.015

Author

Berentzen, Tina Landsvig ; Gamborg, Michael ; Holst, Claus ; Sørensen, Thorkild I A ; Baker, Jennifer L. / Body mass index in childhood and adult risk of primary liver cancer. In: Journal of Hepatology. 2014 ; Vol. 60, No. 2. pp. 325-30.

Bibtex

@article{2895f022e82c4afdac17fd99f2eca410,

title = "Body mass index in childhood and adult risk of primary liver cancer",

abstract = "BACKGROUND & AIMS: Childhood overweight increases the risk of early development of non-alcoholic fatty liver disease, which may predispose to carcinogenesis. We investigated if childhood body size during school ages was associated with the risk of primary liver cancer in adults.METHODS: A cohort of 285,884 boys and girls, born 1930 through 1980, who attended school in Copenhagen, were followed from 1977 to 31 December 2010. Their heights and weights were measured by school doctors or nurses at ages 7 through 13 years. Body mass index (BMI) z-scores were calculated from an internal age- and sex-specific reference. Information on liver cancer was obtained from the National Cancer Registry. Hazard ratios and 95% confidence intervals (95% CI) of liver cancer were estimated by Cox regression.RESULTS: During 6,963,105 person-years of follow-up, 438 cases of primary liver cancer were recorded. The hazard ratio (95% CI) of adult liver cancer was 1.20 (1.07-1.33) and 1.30 (1.16-1.46) per 1-unit BMI z-score at 7 years and 13 years of age, respectively. Similar associations were found in boys and girls, for hepatocellular carcinoma only, across years of birth, and after accounting for diagnoses of viral hepatitis, alcohol-related disorders, and biliary cirrhosis.CONCLUSIONS: Higher BMI in childhood increases the risk of primary liver cancer in adults. In view of the high case fatality of primary liver cancer, this result adds to the future negative health outcomes of the epidemic of childhood overweight, reinforcing the need for its prevention.",

keywords = "Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Body Mass Index, Carcinoma, Hepatocellular, Child, Cohort Studies, Denmark, Fatty Liver, Female, Humans, Liver Neoplasms, Male, Middle Aged, Non-alcoholic Fatty Liver Disease, Overweight, Prospective Studies, Risk Factors",

author = "Berentzen, {Tina Landsvig} and Michael Gamborg and Claus Holst and S{\o}rensen, {Thorkild I A} and Baker, {Jennifer L}",

year = "2014",

month = feb,

doi = "10.1016/j.jhep.2013.09.015",

language = "English",

volume = "60",

pages = "325--30",

journal = "Journal of Hepatology, Supplement",

issn = "0169-5185",

publisher = "Elsevier",

number = "2",

}

RIS

TY - JOUR

T1 - Body mass index in childhood and adult risk of primary liver cancer

AU - Berentzen, Tina Landsvig

AU - Gamborg, Michael

AU - Holst, Claus

AU - Sørensen, Thorkild I A

AU - Baker, Jennifer L

PY - 2014/2

Y1 - 2014/2

N2 - BACKGROUND & AIMS: Childhood overweight increases the risk of early development of non-alcoholic fatty liver disease, which may predispose to carcinogenesis. We investigated if childhood body size during school ages was associated with the risk of primary liver cancer in adults.METHODS: A cohort of 285,884 boys and girls, born 1930 through 1980, who attended school in Copenhagen, were followed from 1977 to 31 December 2010. Their heights and weights were measured by school doctors or nurses at ages 7 through 13 years. Body mass index (BMI) z-scores were calculated from an internal age- and sex-specific reference. Information on liver cancer was obtained from the National Cancer Registry. Hazard ratios and 95% confidence intervals (95% CI) of liver cancer were estimated by Cox regression.RESULTS: During 6,963,105 person-years of follow-up, 438 cases of primary liver cancer were recorded. The hazard ratio (95% CI) of adult liver cancer was 1.20 (1.07-1.33) and 1.30 (1.16-1.46) per 1-unit BMI z-score at 7 years and 13 years of age, respectively. Similar associations were found in boys and girls, for hepatocellular carcinoma only, across years of birth, and after accounting for diagnoses of viral hepatitis, alcohol-related disorders, and biliary cirrhosis.CONCLUSIONS: Higher BMI in childhood increases the risk of primary liver cancer in adults. In view of the high case fatality of primary liver cancer, this result adds to the future negative health outcomes of the epidemic of childhood overweight, reinforcing the need for its prevention.

AB - BACKGROUND & AIMS: Childhood overweight increases the risk of early development of non-alcoholic fatty liver disease, which may predispose to carcinogenesis. We investigated if childhood body size during school ages was associated with the risk of primary liver cancer in adults.METHODS: A cohort of 285,884 boys and girls, born 1930 through 1980, who attended school in Copenhagen, were followed from 1977 to 31 December 2010. Their heights and weights were measured by school doctors or nurses at ages 7 through 13 years. Body mass index (BMI) z-scores were calculated from an internal age- and sex-specific reference. Information on liver cancer was obtained from the National Cancer Registry. Hazard ratios and 95% confidence intervals (95% CI) of liver cancer were estimated by Cox regression.RESULTS: During 6,963,105 person-years of follow-up, 438 cases of primary liver cancer were recorded. The hazard ratio (95% CI) of adult liver cancer was 1.20 (1.07-1.33) and 1.30 (1.16-1.46) per 1-unit BMI z-score at 7 years and 13 years of age, respectively. Similar associations were found in boys and girls, for hepatocellular carcinoma only, across years of birth, and after accounting for diagnoses of viral hepatitis, alcohol-related disorders, and biliary cirrhosis.CONCLUSIONS: Higher BMI in childhood increases the risk of primary liver cancer in adults. In view of the high case fatality of primary liver cancer, this result adds to the future negative health outcomes of the epidemic of childhood overweight, reinforcing the need for its prevention.

KW - Adolescent

KW - Adult

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - Body Mass Index

KW - Carcinoma, Hepatocellular

KW - Child

KW - Cohort Studies

KW - Denmark

KW - Fatty Liver

KW - Female

KW - Humans

KW - Liver Neoplasms

KW - Male

KW - Middle Aged

KW - Non-alcoholic Fatty Liver Disease

KW - Overweight

KW - Prospective Studies

KW - Risk Factors

U2 - 10.1016/j.jhep.2013.09.015

DO - 10.1016/j.jhep.2013.09.015

M3 - Journal article

C2 - 24076363

VL - 60

SP - 325

EP - 330

JO - Journal of Hepatology, Supplement

JF - Journal of Hepatology, Supplement

SN - 0169-5185

IS - 2

ER -

ID: 138557586