Atrial Fibrillation (AFIB) in the ICU - Alle medarbejdere på Institut for Folkesundhedsvidenskab

Atrial Fibrillation (AFIB) in the ICU: Incidence, Risk Factors, and Outcomes: The International AFIB-ICU Cohort Study

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Atrial Fibrillation (AFIB) in the ICU : Incidence, Risk Factors, and Outcomes: The International AFIB-ICU Cohort Study. / Wetterslev, Mik; Hylander Møller, Morten; Granholm, Anders; Hassager, Christian; Haase, Nicolai; Lange, Theis; Myatra, Sheila N.; Hästbacka, Johanna; Arabi, Yaseen M.; Shen, Jiawei; Cronhjort, Maria; Lindqvist, Elin; Aneman, Anders; Young, Paul J.; Szczeklik, Wojciech; Siegemund, Martin; Koster, Thijs; Aslam, Tayyba Naz; Bestle, Morten H.; Girkov, Mia S.; Kalvit, Kushal; Mohanty, Rakesh; Mascarenhas, Joanne; Pattnaik, Manoranjan; Vergis, Sara; Haranath, Sai Praveen; Shah, Mehul; Joshi, Ziyokov; Wilkman, Erika; Reinikainen, Matti; Lehto, Pasi; Jalkanen, Ville; Pulkkinen, Anni; An, Youzhong; Wang, Guoxing; Huang, Lei; Huang, Bin; Liu, Wei; Gao, Hengbo; Dou, Lin; Li, Shuangling; Yang, Wanchun; Tegnell, Emily; Perner, Anders; Poulsen, Lone M.; Hildebrandt, Thomas; Sofie Andreasen, Anne; Tjelle Kristiansen, Klaus; Mohr, Thomas; Møller, Kirsten; the AFIB-ICU collaborators.

In: Critical Care Medicine, Vol. 51, No. 9, 2023, p. 1124-1137.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Wetterslev, M, Hylander Møller, M, Granholm, A, Hassager, C, Haase, N, Lange, T, Myatra, SN, Hästbacka, J, Arabi, YM, Shen, J, Cronhjort, M, Lindqvist, E, Aneman, A, Young, PJ, Szczeklik, W, Siegemund, M, Koster, T, Aslam, TN, Bestle, MH, Girkov, MS, Kalvit, K, Mohanty, R, Mascarenhas, J, Pattnaik, M, Vergis, S, Haranath, SP, Shah, M, Joshi, Z, Wilkman, E, Reinikainen, M, Lehto, P, Jalkanen, V, Pulkkinen, A, An, Y, Wang, G, Huang, L, Huang, B, Liu, W, Gao, H, Dou, L, Li, S, Yang, W, Tegnell, E, Perner, A, Poulsen, LM, Hildebrandt, T, Sofie Andreasen, A, Tjelle Kristiansen, K, Mohr, T, Møller, K & the AFIB-ICU collaborators 2023, 'Atrial Fibrillation (AFIB) in the ICU: Incidence, Risk Factors, and Outcomes: The International AFIB-ICU Cohort Study', Critical Care Medicine, vol. 51, no. 9, pp. 1124-1137. https://doi.org/10.1097/CCM.0000000000005883

APA

Wetterslev, M., Hylander Møller, M., Granholm, A., Hassager, C., Haase, N., Lange, T., Myatra, S. N., Hästbacka, J., Arabi, Y. M., Shen, J., Cronhjort, M., Lindqvist, E., Aneman, A., Young, P. J., Szczeklik, W., Siegemund, M., Koster, T., Aslam, T. N., Bestle, M. H., ... the AFIB-ICU collaborators (2023). Atrial Fibrillation (AFIB) in the ICU: Incidence, Risk Factors, and Outcomes: The International AFIB-ICU Cohort Study. Critical Care Medicine, 51(9), 1124-1137. https://doi.org/10.1097/CCM.0000000000005883

Vancouver

Wetterslev M, Hylander Møller M, Granholm A, Hassager C, Haase N, Lange T et al. Atrial Fibrillation (AFIB) in the ICU: Incidence, Risk Factors, and Outcomes: The International AFIB-ICU Cohort Study. Critical Care Medicine. 2023;51(9):1124-1137. https://doi.org/10.1097/CCM.0000000000005883

Author

Wetterslev, Mik ; Hylander Møller, Morten ; Granholm, Anders ; Hassager, Christian ; Haase, Nicolai ; Lange, Theis ; Myatra, Sheila N. ; Hästbacka, Johanna ; Arabi, Yaseen M. ; Shen, Jiawei ; Cronhjort, Maria ; Lindqvist, Elin ; Aneman, Anders ; Young, Paul J. ; Szczeklik, Wojciech ; Siegemund, Martin ; Koster, Thijs ; Aslam, Tayyba Naz ; Bestle, Morten H. ; Girkov, Mia S. ; Kalvit, Kushal ; Mohanty, Rakesh ; Mascarenhas, Joanne ; Pattnaik, Manoranjan ; Vergis, Sara ; Haranath, Sai Praveen ; Shah, Mehul ; Joshi, Ziyokov ; Wilkman, Erika ; Reinikainen, Matti ; Lehto, Pasi ; Jalkanen, Ville ; Pulkkinen, Anni ; An, Youzhong ; Wang, Guoxing ; Huang, Lei ; Huang, Bin ; Liu, Wei ; Gao, Hengbo ; Dou, Lin ; Li, Shuangling ; Yang, Wanchun ; Tegnell, Emily ; Perner, Anders ; Poulsen, Lone M. ; Hildebrandt, Thomas ; Sofie Andreasen, Anne ; Tjelle Kristiansen, Klaus ; Mohr, Thomas ; Møller, Kirsten ; the AFIB-ICU collaborators. / Atrial Fibrillation (AFIB) in the ICU : Incidence, Risk Factors, and Outcomes: The International AFIB-ICU Cohort Study. In: Critical Care Medicine. 2023 ; Vol. 51, No. 9. pp. 1124-1137.

Bibtex

@article{65e16a20e2ac44a6940cfe3b64a735e9,

title = "Atrial Fibrillation (AFIB) in the ICU: Incidence, Risk Factors, and Outcomes: The International AFIB-ICU Cohort Study",

abstract = "OBJECTIVES: To assess the incidence, risk factors, and outcomes of atrial fibrillation (AF) in the ICU and to describe current practice in the management of AF. DESIGN: Multicenter, prospective, inception cohort study. SETTING: Forty-four ICUs in 12 countries in four geographical regions. SUBJECTS: Adult, acutely admitted ICU patients without a history of persistent/permanent AF or recent cardiac surgery were enrolled; inception periods were from October 2020 to June 2021. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: We included 1,423 ICU patients and analyzed 1,415 (99.4%), among whom 221 patients had 539 episodes of AF. Most (59%) episodes were diagnosed with continuous electrocardiogram monitoring. The incidence of AF was 15.6% (95% CI, 13.8-17.6), of which newly developed AF was 13.3% (11.5-15.1). A history of arterial hypertension, paroxysmal AF, sepsis, or high disease severity at ICU admission was associated with AF. Used interventions to manage AF were fluid bolus 19% (95% CI 16-23), magnesium 16% (13-20), potassium 15% (12-19), amiodarone 51% (47-55), beta-1 selective blockers 34% (30-38), calcium channel blockers 4% (2-6), digoxin 16% (12-19), and direct current cardioversion in 4% (2-6). Patients with AF had more ischemic, thromboembolic (13.6% vs 7.9%), and severe bleeding events (5.9% vs 2.1%), and higher mortality (41.2% vs 25.2%) than those without AF. The adjusted cause-specific hazard ratio for 90-day mortality by AF was 1.38 (95% CI, 0.95-1.99). CONCLUSIONS: In ICU patients, AF occurred in one of six and was associated with different conditions. AF was associated with worse outcomes while not statistically significantly associated with 90-day mortality in the adjusted analyses. We observed variations in the diagnostic and management strategies for AF.",

keywords = "adverse outcomes, critical illness, intensive care units, management, newly developed atrial fibrillation",

author = "Mik Wetterslev and {Hylander M{\o}ller}, Morten and Anders Granholm and Christian Hassager and Nicolai Haase and Theis Lange and Myatra, {Sheila N.} and Johanna H{\"a}stbacka and Arabi, {Yaseen M.} and Jiawei Shen and Maria Cronhjort and Elin Lindqvist and Anders Aneman and Young, {Paul J.} and Wojciech Szczeklik and Martin Siegemund and Thijs Koster and Aslam, {Tayyba Naz} and Bestle, {Morten H.} and Girkov, {Mia S.} and Kushal Kalvit and Rakesh Mohanty and Joanne Mascarenhas and Manoranjan Pattnaik and Sara Vergis and Haranath, {Sai Praveen} and Mehul Shah and Ziyokov Joshi and Erika Wilkman and Matti Reinikainen and Pasi Lehto and Ville Jalkanen and Anni Pulkkinen and Youzhong An and Guoxing Wang and Lei Huang and Bin Huang and Wei Liu and Hengbo Gao and Lin Dou and Shuangling Li and Wanchun Yang and Emily Tegnell and Anders Perner and Poulsen, {Lone M.} and Thomas Hildebrandt and {Sofie Andreasen}, Anne and {Tjelle Kristiansen}, Klaus and Thomas Mohr and Kirsten M{\o}ller and {the AFIB-ICU collaborators}",

year = "2023",

doi = "10.1097/CCM.0000000000005883",

language = "English",

volume = "51",

pages = "1124--1137",

journal = "New Horizons: Science and Practice of Acute Medicine",

issn = "1063-7389",

publisher = "Williams & Wilkins",

number = "9",

}

RIS

TY - JOUR

T1 - Atrial Fibrillation (AFIB) in the ICU

T2 - Incidence, Risk Factors, and Outcomes: The International AFIB-ICU Cohort Study

AU - Wetterslev, Mik

AU - Hylander Møller, Morten

AU - Granholm, Anders

AU - Hassager, Christian

AU - Haase, Nicolai

AU - Lange, Theis

AU - Myatra, Sheila N.

AU - Hästbacka, Johanna

AU - Arabi, Yaseen M.

AU - Shen, Jiawei

AU - Cronhjort, Maria

AU - Lindqvist, Elin

AU - Aneman, Anders

AU - Young, Paul J.

AU - Szczeklik, Wojciech

AU - Siegemund, Martin

AU - Koster, Thijs

AU - Aslam, Tayyba Naz

AU - Bestle, Morten H.

AU - Girkov, Mia S.

AU - Kalvit, Kushal

AU - Mohanty, Rakesh

AU - Mascarenhas, Joanne

AU - Pattnaik, Manoranjan

AU - Vergis, Sara

AU - Haranath, Sai Praveen

AU - Shah, Mehul

AU - Joshi, Ziyokov

AU - Wilkman, Erika

AU - Reinikainen, Matti

AU - Lehto, Pasi

AU - Jalkanen, Ville

AU - Pulkkinen, Anni

AU - An, Youzhong

AU - Wang, Guoxing

AU - Huang, Lei

AU - Huang, Bin

AU - Liu, Wei

AU - Gao, Hengbo

AU - Dou, Lin

AU - Li, Shuangling

AU - Yang, Wanchun

AU - Tegnell, Emily

AU - Perner, Anders

AU - Poulsen, Lone M.

AU - Hildebrandt, Thomas

AU - Sofie Andreasen, Anne

AU - Tjelle Kristiansen, Klaus

AU - Mohr, Thomas

AU - Møller, Kirsten

AU - the AFIB-ICU collaborators

PY - 2023

Y1 - 2023

N2 - OBJECTIVES: To assess the incidence, risk factors, and outcomes of atrial fibrillation (AF) in the ICU and to describe current practice in the management of AF. DESIGN: Multicenter, prospective, inception cohort study. SETTING: Forty-four ICUs in 12 countries in four geographical regions. SUBJECTS: Adult, acutely admitted ICU patients without a history of persistent/permanent AF or recent cardiac surgery were enrolled; inception periods were from October 2020 to June 2021. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: We included 1,423 ICU patients and analyzed 1,415 (99.4%), among whom 221 patients had 539 episodes of AF. Most (59%) episodes were diagnosed with continuous electrocardiogram monitoring. The incidence of AF was 15.6% (95% CI, 13.8-17.6), of which newly developed AF was 13.3% (11.5-15.1). A history of arterial hypertension, paroxysmal AF, sepsis, or high disease severity at ICU admission was associated with AF. Used interventions to manage AF were fluid bolus 19% (95% CI 16-23), magnesium 16% (13-20), potassium 15% (12-19), amiodarone 51% (47-55), beta-1 selective blockers 34% (30-38), calcium channel blockers 4% (2-6), digoxin 16% (12-19), and direct current cardioversion in 4% (2-6). Patients with AF had more ischemic, thromboembolic (13.6% vs 7.9%), and severe bleeding events (5.9% vs 2.1%), and higher mortality (41.2% vs 25.2%) than those without AF. The adjusted cause-specific hazard ratio for 90-day mortality by AF was 1.38 (95% CI, 0.95-1.99). CONCLUSIONS: In ICU patients, AF occurred in one of six and was associated with different conditions. AF was associated with worse outcomes while not statistically significantly associated with 90-day mortality in the adjusted analyses. We observed variations in the diagnostic and management strategies for AF.

AB - OBJECTIVES: To assess the incidence, risk factors, and outcomes of atrial fibrillation (AF) in the ICU and to describe current practice in the management of AF. DESIGN: Multicenter, prospective, inception cohort study. SETTING: Forty-four ICUs in 12 countries in four geographical regions. SUBJECTS: Adult, acutely admitted ICU patients without a history of persistent/permanent AF or recent cardiac surgery were enrolled; inception periods were from October 2020 to June 2021. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: We included 1,423 ICU patients and analyzed 1,415 (99.4%), among whom 221 patients had 539 episodes of AF. Most (59%) episodes were diagnosed with continuous electrocardiogram monitoring. The incidence of AF was 15.6% (95% CI, 13.8-17.6), of which newly developed AF was 13.3% (11.5-15.1). A history of arterial hypertension, paroxysmal AF, sepsis, or high disease severity at ICU admission was associated with AF. Used interventions to manage AF were fluid bolus 19% (95% CI 16-23), magnesium 16% (13-20), potassium 15% (12-19), amiodarone 51% (47-55), beta-1 selective blockers 34% (30-38), calcium channel blockers 4% (2-6), digoxin 16% (12-19), and direct current cardioversion in 4% (2-6). Patients with AF had more ischemic, thromboembolic (13.6% vs 7.9%), and severe bleeding events (5.9% vs 2.1%), and higher mortality (41.2% vs 25.2%) than those without AF. The adjusted cause-specific hazard ratio for 90-day mortality by AF was 1.38 (95% CI, 0.95-1.99). CONCLUSIONS: In ICU patients, AF occurred in one of six and was associated with different conditions. AF was associated with worse outcomes while not statistically significantly associated with 90-day mortality in the adjusted analyses. We observed variations in the diagnostic and management strategies for AF.

KW - adverse outcomes

KW - critical illness

KW - intensive care units

KW - management

KW - newly developed atrial fibrillation

U2 - 10.1097/CCM.0000000000005883

DO - 10.1097/CCM.0000000000005883

M3 - Journal article

C2 - 37078722

AN - SCOPUS:85160112433

VL - 51

SP - 1124

EP - 1137

JO - New Horizons: Science and Practice of Acute Medicine

JF - New Horizons: Science and Practice of Acute Medicine

SN - 1063-7389

IS - 9

ER -

ID: 365923600