Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer

Research output: Contribution to journal › Journal article › Research › peer-review

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Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer. / Mustieles, Vicente; Perez-Carrascosa, Francisco M.; Leon, Josefa; Lange, Theis; Bonde, Jens-Peter; Gomez-Pena, Celia; Artacho-Cordon, Francisco; Barrios-Rodriguez, Rocio; Olmedo-Requena, Rocio; Exposito, Jose; Jimenez-Moleon, Jose J.; Arrebola, Juan P.

In: Environmental Science & Technology, Vol. 55, No. 14, 2021, p. 9926-9937.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Mustieles, V, Perez-Carrascosa, FM, Leon, J, Lange, T, Bonde, J-P, Gomez-Pena, C, Artacho-Cordon, F, Barrios-Rodriguez, R, Olmedo-Requena, R, Exposito, J, Jimenez-Moleon, JJ & Arrebola, JP 2021, 'Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer', Environmental Science & Technology, vol. 55, no. 14, pp. 9926-9937. https://doi.org/10.1021/acs.est.0c08180

APA

Mustieles, V., Perez-Carrascosa, F. M., Leon, J., Lange, T., Bonde, J-P., Gomez-Pena, C., Artacho-Cordon, F., Barrios-Rodriguez, R., Olmedo-Requena, R., Exposito, J., Jimenez-Moleon, J. J., & Arrebola, J. P. (2021). Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer. Environmental Science & Technology, 55(14), 9926-9937. https://doi.org/10.1021/acs.est.0c08180

Vancouver

Mustieles V, Perez-Carrascosa FM, Leon J, Lange T, Bonde J-P, Gomez-Pena C et al. Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer. Environmental Science & Technology. 2021;55(14):9926-9937. https://doi.org/10.1021/acs.est.0c08180

Author

Mustieles, Vicente ; Perez-Carrascosa, Francisco M. ; Leon, Josefa ; Lange, Theis ; Bonde, Jens-Peter ; Gomez-Pena, Celia ; Artacho-Cordon, Francisco ; Barrios-Rodriguez, Rocio ; Olmedo-Requena, Rocio ; Exposito, Jose ; Jimenez-Moleon, Jose J. ; Arrebola, Juan P. / Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer. In: Environmental Science & Technology. 2021 ; Vol. 55, No. 14. pp. 9926-9937.

Bibtex

@article{eea06a52e53b442398d5f4f1ecec291a,
title = "Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer",
abstract = "We aimed to assess the relationships among the adipose tissue's (AT) oxidative microenvironment, in situ accumulated persistent organic pollutant (POP) concentrations, and cancer development. POP and oxidative stress levels were quantified in AT samples from 382 adults recruited within the GraMo cohort (2003-2004) in Granada (Spain). The 16-year cancer incidence was ascertained by reviewing health/administrative databases. Cox-regression models and mediation analyses were performed. The enzymes superoxide dismutase (SOD) and glutathione reductase (GRd) were positively associated with the risk of non-hormone-dependent (NHD) cancer [adjusted hazard ratio (HR) 1.76; 95% confidence interval (CI): 1.17, 2.64 and HR 2.35; 95% CI: 1.41, 3.94, respectively]. After adjustment for covariates, polychlorinated biphenyl-138 (PCB-138) (HR 1.78; 95% CI: 1.03, 3.09), beta-hexachlorocyclohexane (beta-HCH) (HR 1.70; 95% CI: 1.09, 2.64), and hexachlorobenzene (HR 1.54; 95% CI: 1.02, 2.33) were also positively associated with the risk of NHD cancer. Although confidence intervals included the null value, probably because of the modest number of cancer cases, we observed a potential mediation effect of SOD and GRd on the associations between beta-HCH and the risk of NHD tumors (percent mediated = 33 and 47%, respectively). Our results highlight the relevance of human AT's oxidative microenvironment as a predictor of future cancer risk as well as its potential mediating role on POP-related carcinogenesis. Given their novelty, these findings should be interpreted with caution and confirmed in future studies.",
keywords = "oxidative stress, persistent organic pollutants, organochlorine pesticides, polychlorinated biphenyls, cancer, POLYCHLORINATED-BIPHENYLS, OXIDATIVE STRESS, ADULT COHORT, ORGANOCHLORINE PESTICIDES, CHRONIC EXPOSURE, PROSTATE-CANCER, BREAST-CANCER, SERUM CONCENTRATIONS, COLORECTAL-CANCER, DNA-ADDUCTS",
author = "Vicente Mustieles and Perez-Carrascosa, {Francisco M.} and Josefa Leon and Theis Lange and Jens-Peter Bonde and Celia Gomez-Pena and Francisco Artacho-Cordon and Rocio Barrios-Rodriguez and Rocio Olmedo-Requena and Jose Exposito and Jimenez-Moleon, {Jose J.} and Arrebola, {Juan P.}",
year = "2021",
doi = "10.1021/acs.est.0c08180",
language = "English",
volume = "55",
pages = "9926--9937",
journal = "Environmental Science & Technology",
issn = "0013-936X",
publisher = "American Chemical Society",
number = "14",

}

RIS

TY - JOUR

T1 - Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer

AU - Mustieles, Vicente

AU - Perez-Carrascosa, Francisco M.

AU - Leon, Josefa

AU - Lange, Theis

AU - Bonde, Jens-Peter

AU - Gomez-Pena, Celia

AU - Artacho-Cordon, Francisco

AU - Barrios-Rodriguez, Rocio

AU - Olmedo-Requena, Rocio

AU - Exposito, Jose

AU - Jimenez-Moleon, Jose J.

AU - Arrebola, Juan P.

PY - 2021

Y1 - 2021

N2 - We aimed to assess the relationships among the adipose tissue's (AT) oxidative microenvironment, in situ accumulated persistent organic pollutant (POP) concentrations, and cancer development. POP and oxidative stress levels were quantified in AT samples from 382 adults recruited within the GraMo cohort (2003-2004) in Granada (Spain). The 16-year cancer incidence was ascertained by reviewing health/administrative databases. Cox-regression models and mediation analyses were performed. The enzymes superoxide dismutase (SOD) and glutathione reductase (GRd) were positively associated with the risk of non-hormone-dependent (NHD) cancer [adjusted hazard ratio (HR) 1.76; 95% confidence interval (CI): 1.17, 2.64 and HR 2.35; 95% CI: 1.41, 3.94, respectively]. After adjustment for covariates, polychlorinated biphenyl-138 (PCB-138) (HR 1.78; 95% CI: 1.03, 3.09), beta-hexachlorocyclohexane (beta-HCH) (HR 1.70; 95% CI: 1.09, 2.64), and hexachlorobenzene (HR 1.54; 95% CI: 1.02, 2.33) were also positively associated with the risk of NHD cancer. Although confidence intervals included the null value, probably because of the modest number of cancer cases, we observed a potential mediation effect of SOD and GRd on the associations between beta-HCH and the risk of NHD tumors (percent mediated = 33 and 47%, respectively). Our results highlight the relevance of human AT's oxidative microenvironment as a predictor of future cancer risk as well as its potential mediating role on POP-related carcinogenesis. Given their novelty, these findings should be interpreted with caution and confirmed in future studies.

AB - We aimed to assess the relationships among the adipose tissue's (AT) oxidative microenvironment, in situ accumulated persistent organic pollutant (POP) concentrations, and cancer development. POP and oxidative stress levels were quantified in AT samples from 382 adults recruited within the GraMo cohort (2003-2004) in Granada (Spain). The 16-year cancer incidence was ascertained by reviewing health/administrative databases. Cox-regression models and mediation analyses were performed. The enzymes superoxide dismutase (SOD) and glutathione reductase (GRd) were positively associated with the risk of non-hormone-dependent (NHD) cancer [adjusted hazard ratio (HR) 1.76; 95% confidence interval (CI): 1.17, 2.64 and HR 2.35; 95% CI: 1.41, 3.94, respectively]. After adjustment for covariates, polychlorinated biphenyl-138 (PCB-138) (HR 1.78; 95% CI: 1.03, 3.09), beta-hexachlorocyclohexane (beta-HCH) (HR 1.70; 95% CI: 1.09, 2.64), and hexachlorobenzene (HR 1.54; 95% CI: 1.02, 2.33) were also positively associated with the risk of NHD cancer. Although confidence intervals included the null value, probably because of the modest number of cancer cases, we observed a potential mediation effect of SOD and GRd on the associations between beta-HCH and the risk of NHD tumors (percent mediated = 33 and 47%, respectively). Our results highlight the relevance of human AT's oxidative microenvironment as a predictor of future cancer risk as well as its potential mediating role on POP-related carcinogenesis. Given their novelty, these findings should be interpreted with caution and confirmed in future studies.

KW - oxidative stress

KW - persistent organic pollutants

KW - organochlorine pesticides

KW - polychlorinated biphenyls

KW - cancer

KW - POLYCHLORINATED-BIPHENYLS

KW - OXIDATIVE STRESS

KW - ADULT COHORT

KW - ORGANOCHLORINE PESTICIDES

KW - CHRONIC EXPOSURE

KW - PROSTATE-CANCER

KW - BREAST-CANCER

KW - SERUM CONCENTRATIONS

KW - COLORECTAL-CANCER

KW - DNA-ADDUCTS

U2 - 10.1021/acs.est.0c08180

DO - 10.1021/acs.est.0c08180

M3 - Journal article

C2 - 34180659

VL - 55

SP - 9926

EP - 9937

JO - Environmental Science & Technology

JF - Environmental Science & Technology

SN - 0013-936X

IS - 14

ER -

ID: 275817601