A marginal structural model for recurrent events in the presence of time-dependent confounding: non-specific effects of vaccines on child hospitalisations

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Using a Danish register-based study on childhood vaccination and hospitalisation as motivation, a marginal structural model for recurrent events is studied. The model addresses a number of challenges which may be seen more generally in large register-based cohort studies. One is to adjust for a time-dependent confounder when studying the effect of a time-varying exposure on a recurrent event based on an analysis in continuous time. Another is to report results via a measure which is easy to interpret and communicate even though quite elaborate treatment regimes are considered. Lastly, the implementation of continuously updated weights implies a substantial computationally demanding workload.
Original languageEnglish
JournalStatistics in Medicine
Issue number27
Pages (from-to)5051-5069
Number of pages19
Publication statusPublished - 30 Nov 2016

ID: 173742060