Weight change across adulthood and accelerated biological aging in middle-aged and older adults
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Weight change across adulthood and accelerated biological aging in middle-aged and older adults. / Cao, Xingqi; Yang, Gan; Li, Xueqin; Fu, Jinjing; Mohedaner, Mayila; Danzengzhuoga, ; Jørgensen, Terese Sara Høj; Agogo, George O.; Wang, Liang; Zhang, Xuehong; Zhang, Tao; Han, Liyuan; Gao, Xiang; Liu, Zuyun.
I: The American Journal of Clinical Nutrition, Bind 117, Nr. 1, 2023, s. 1-11.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Weight change across adulthood and accelerated biological aging in middle-aged and older adults
AU - Cao, Xingqi
AU - Yang, Gan
AU - Li, Xueqin
AU - Fu, Jinjing
AU - Mohedaner, Mayila
AU - Danzengzhuoga, null
AU - Jørgensen, Terese Sara Høj
AU - Agogo, George O.
AU - Wang, Liang
AU - Zhang, Xuehong
AU - Zhang, Tao
AU - Han, Liyuan
AU - Gao, Xiang
AU - Liu, Zuyun
PY - 2023
Y1 - 2023
N2 - ObjectivesThis study aimed to estimate the influence of weight change across adulthood on biological aging acceleration in middle-aged and older adults in the United States.MethodsWe used data of 5553 adults (40–84 y) from the National Health and Nutrition Examination Survey 1999–2010. Weight change patterns (i.e., stable normal, maximal overweight, obese to nonobese, nonobese to obese, and stable obese) and absolute weight change groups across adulthood (i.e., from young to middle adulthood, young to late adulthood, and middle to late adulthood) were defined. A biological aging measure (i.e., phenotypic age acceleration [PhenoAgeAccel]) at late adulthood was calculated. Survey analysis procedures with the survey weights were performed.ResultsAcross adulthood, maximal overweight, nonobese to obese, and stable obesity were consistently associated with higher PhenoAgeAccel. For instance, from young to middle adulthood, compared with participants who had stable normal weight, participants experiencing maximal overweight, moving from the nonobese to obese, and maintaining obesity had 1.71 (standard error [SE], 0.21; P < 0.001), 3.62 (SE, 0.28; P < 0.001), and 6.61 (SE, 0.58; P < 0.001) higher PhenoAgeAccel values, respectively. From young to middle adulthood, relative to absolute weight loss or gain of <2.5 kg, weight loss of ≥2.5 kg was marginally associated with lower PhenoAgeAccel (P = 0.054), whereas an obese to nonobese pattern from middle to late adulthood was associated with higher PhenoAgeAccel (P < 0.001).ConclusionsMaximal overweight, nonobese to obese, and stable obesity across adulthood, as well as an obese to nonobese pattern from middle to late adulthood, were associated with accelerated biological aging. In contrast, weight loss from young to middle adulthood was associated with decelerated biological aging. The findings highlight the potential role of weight management across adulthood for aging. Monitoring weight fluctuation may help identify the population at high risk of accelerated aging
AB - ObjectivesThis study aimed to estimate the influence of weight change across adulthood on biological aging acceleration in middle-aged and older adults in the United States.MethodsWe used data of 5553 adults (40–84 y) from the National Health and Nutrition Examination Survey 1999–2010. Weight change patterns (i.e., stable normal, maximal overweight, obese to nonobese, nonobese to obese, and stable obese) and absolute weight change groups across adulthood (i.e., from young to middle adulthood, young to late adulthood, and middle to late adulthood) were defined. A biological aging measure (i.e., phenotypic age acceleration [PhenoAgeAccel]) at late adulthood was calculated. Survey analysis procedures with the survey weights were performed.ResultsAcross adulthood, maximal overweight, nonobese to obese, and stable obesity were consistently associated with higher PhenoAgeAccel. For instance, from young to middle adulthood, compared with participants who had stable normal weight, participants experiencing maximal overweight, moving from the nonobese to obese, and maintaining obesity had 1.71 (standard error [SE], 0.21; P < 0.001), 3.62 (SE, 0.28; P < 0.001), and 6.61 (SE, 0.58; P < 0.001) higher PhenoAgeAccel values, respectively. From young to middle adulthood, relative to absolute weight loss or gain of <2.5 kg, weight loss of ≥2.5 kg was marginally associated with lower PhenoAgeAccel (P = 0.054), whereas an obese to nonobese pattern from middle to late adulthood was associated with higher PhenoAgeAccel (P < 0.001).ConclusionsMaximal overweight, nonobese to obese, and stable obesity across adulthood, as well as an obese to nonobese pattern from middle to late adulthood, were associated with accelerated biological aging. In contrast, weight loss from young to middle adulthood was associated with decelerated biological aging. The findings highlight the potential role of weight management across adulthood for aging. Monitoring weight fluctuation may help identify the population at high risk of accelerated aging
KW - biological aging
KW - body mass index
KW - body weight changes
KW - obesity
KW - phenotypic age acceleration
U2 - 10.1016/j.ajcnut.2022.10.020
DO - 10.1016/j.ajcnut.2022.10.020
M3 - Journal article
C2 - 36789928
VL - 117
SP - 1
EP - 11
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 1
ER -
ID: 331589411