Vitamin D Concentrations at Birth and the Risk of Rheumatoid Arthritis in Early Adulthood: A Danish Population-Based Case-Cohort Study

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Vitamin D Concentrations at Birth and the Risk of Rheumatoid Arthritis in Early Adulthood : A Danish Population-Based Case-Cohort Study. / Cardoso, Isabel; Specht, Ina Olmer; Thorsteinsdottir, Fanney; Thorbek, Marta Jadwiga; Keller, Amélie; Stougaard, Maria; Cohen, Arieh S.; Händel, Mina Nicole; Kristensen, Lars Erik; Heitmann, Berit Lilienthal.

I: Nutrients, Bind 14, Nr. 3, 447, 2022.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Cardoso, I, Specht, IO, Thorsteinsdottir, F, Thorbek, MJ, Keller, A, Stougaard, M, Cohen, AS, Händel, MN, Kristensen, LE & Heitmann, BL 2022, 'Vitamin D Concentrations at Birth and the Risk of Rheumatoid Arthritis in Early Adulthood: A Danish Population-Based Case-Cohort Study', Nutrients, bind 14, nr. 3, 447. https://doi.org/10.3390/nu14030447

APA

Cardoso, I., Specht, I. O., Thorsteinsdottir, F., Thorbek, M. J., Keller, A., Stougaard, M., Cohen, A. S., Händel, M. N., Kristensen, L. E., & Heitmann, B. L. (2022). Vitamin D Concentrations at Birth and the Risk of Rheumatoid Arthritis in Early Adulthood: A Danish Population-Based Case-Cohort Study. Nutrients, 14(3), [447]. https://doi.org/10.3390/nu14030447

Vancouver

Cardoso I, Specht IO, Thorsteinsdottir F, Thorbek MJ, Keller A, Stougaard M o.a. Vitamin D Concentrations at Birth and the Risk of Rheumatoid Arthritis in Early Adulthood: A Danish Population-Based Case-Cohort Study. Nutrients. 2022;14(3). 447. https://doi.org/10.3390/nu14030447

Author

Cardoso, Isabel ; Specht, Ina Olmer ; Thorsteinsdottir, Fanney ; Thorbek, Marta Jadwiga ; Keller, Amélie ; Stougaard, Maria ; Cohen, Arieh S. ; Händel, Mina Nicole ; Kristensen, Lars Erik ; Heitmann, Berit Lilienthal. / Vitamin D Concentrations at Birth and the Risk of Rheumatoid Arthritis in Early Adulthood : A Danish Population-Based Case-Cohort Study. I: Nutrients. 2022 ; Bind 14, Nr. 3.

Bibtex

@article{565ac3bf1da94fd89e490c572e99eb28,
title = "Vitamin D Concentrations at Birth and the Risk of Rheumatoid Arthritis in Early Adulthood: A Danish Population-Based Case-Cohort Study",
abstract = "Background: Low vitamin D in pregnancy may impair the development of the fetal immune system and influence the risk of later development of rheumatoid arthritis (RA) in the offspring. The aim was to examine whether lower 25-hydroxyvitamin D3 (25(OH)D) concentrations at birth were associated with the risk of developing RA in early adulthood. Methods: This case-cohort study obtained data from Danish registers and biobanks. Cases included all individuals born during 1981–1996 and recorded in the Danish National Patient Register with a diagnosis of RA with age >18 years at first admission. The random comparison consisted of a subset of Danish children. Vitamin D concentrations were measured in newborn dried blood. In total, 805 RA cases and 2416 individuals from the subcohort were included in the final analysis. Weighted Cox regression was used to calculate hazard ratio (HR). Results: The median (interquartile rage (IQR)) 25(OH)D concentrations among cases were 24.9 nmol/L (IQR:15.4;36.9) and 23.9 nmol/L (IQR:13.6;36.4) among the subcohort. There was no indication of a lower risk of RA among individuals in the highest vitamin D quintile compared with the lowest (HRadj.:1.21 (0.90;1.63)). Conclusion: The risk of RA in early adulthood was not associated with vitamin D concentrations at birth.",
keywords = "Cohort, Denmark, Dried blood spots, Early adulthood, Rheumatoid arthritis, Vitamin D",
author = "Isabel Cardoso and Specht, {Ina Olmer} and Fanney Thorsteinsdottir and Thorbek, {Marta Jadwiga} and Am{\'e}lie Keller and Maria Stougaard and Cohen, {Arieh S.} and H{\"a}ndel, {Mina Nicole} and Kristensen, {Lars Erik} and Heitmann, {Berit Lilienthal}",
note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2022",
doi = "10.3390/nu14030447",
language = "English",
volume = "14",
journal = "Nutrients",
issn = "2072-6643",
publisher = "M D P I AG",
number = "3",

}

RIS

TY - JOUR

T1 - Vitamin D Concentrations at Birth and the Risk of Rheumatoid Arthritis in Early Adulthood

T2 - A Danish Population-Based Case-Cohort Study

AU - Cardoso, Isabel

AU - Specht, Ina Olmer

AU - Thorsteinsdottir, Fanney

AU - Thorbek, Marta Jadwiga

AU - Keller, Amélie

AU - Stougaard, Maria

AU - Cohen, Arieh S.

AU - Händel, Mina Nicole

AU - Kristensen, Lars Erik

AU - Heitmann, Berit Lilienthal

N1 - Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022

Y1 - 2022

N2 - Background: Low vitamin D in pregnancy may impair the development of the fetal immune system and influence the risk of later development of rheumatoid arthritis (RA) in the offspring. The aim was to examine whether lower 25-hydroxyvitamin D3 (25(OH)D) concentrations at birth were associated with the risk of developing RA in early adulthood. Methods: This case-cohort study obtained data from Danish registers and biobanks. Cases included all individuals born during 1981–1996 and recorded in the Danish National Patient Register with a diagnosis of RA with age >18 years at first admission. The random comparison consisted of a subset of Danish children. Vitamin D concentrations were measured in newborn dried blood. In total, 805 RA cases and 2416 individuals from the subcohort were included in the final analysis. Weighted Cox regression was used to calculate hazard ratio (HR). Results: The median (interquartile rage (IQR)) 25(OH)D concentrations among cases were 24.9 nmol/L (IQR:15.4;36.9) and 23.9 nmol/L (IQR:13.6;36.4) among the subcohort. There was no indication of a lower risk of RA among individuals in the highest vitamin D quintile compared with the lowest (HRadj.:1.21 (0.90;1.63)). Conclusion: The risk of RA in early adulthood was not associated with vitamin D concentrations at birth.

AB - Background: Low vitamin D in pregnancy may impair the development of the fetal immune system and influence the risk of later development of rheumatoid arthritis (RA) in the offspring. The aim was to examine whether lower 25-hydroxyvitamin D3 (25(OH)D) concentrations at birth were associated with the risk of developing RA in early adulthood. Methods: This case-cohort study obtained data from Danish registers and biobanks. Cases included all individuals born during 1981–1996 and recorded in the Danish National Patient Register with a diagnosis of RA with age >18 years at first admission. The random comparison consisted of a subset of Danish children. Vitamin D concentrations were measured in newborn dried blood. In total, 805 RA cases and 2416 individuals from the subcohort were included in the final analysis. Weighted Cox regression was used to calculate hazard ratio (HR). Results: The median (interquartile rage (IQR)) 25(OH)D concentrations among cases were 24.9 nmol/L (IQR:15.4;36.9) and 23.9 nmol/L (IQR:13.6;36.4) among the subcohort. There was no indication of a lower risk of RA among individuals in the highest vitamin D quintile compared with the lowest (HRadj.:1.21 (0.90;1.63)). Conclusion: The risk of RA in early adulthood was not associated with vitamin D concentrations at birth.

KW - Cohort

KW - Denmark

KW - Dried blood spots

KW - Early adulthood

KW - Rheumatoid arthritis

KW - Vitamin D

U2 - 10.3390/nu14030447

DO - 10.3390/nu14030447

M3 - Journal article

C2 - 35276806

AN - SCOPUS:85122915242

VL - 14

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 3

M1 - 447

ER -

ID: 291113552