Visual stimuli induce serotonin release in occipital cortex: A simultaneous positron emission tomography/magnetic resonance imaging study
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Visual stimuli induce serotonin release in occipital cortex : A simultaneous positron emission tomography/magnetic resonance imaging study. / Hansen, Hanne Demant; Lindberg, Ulrich; Ozenne, Brice; Fisher, Patrick MacDonald; Johansen, Annette; Svarer, Claus; Keller, Sune Hogild; Hansen, Adam Espe; Knudsen, Gitte Moos.
I: Human Brain Mapping, Bind 41, Nr. 16, 2020, s. 4753-4763.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Visual stimuli induce serotonin release in occipital cortex
T2 - A simultaneous positron emission tomography/magnetic resonance imaging study
AU - Hansen, Hanne Demant
AU - Lindberg, Ulrich
AU - Ozenne, Brice
AU - Fisher, Patrick MacDonald
AU - Johansen, Annette
AU - Svarer, Claus
AU - Keller, Sune Hogild
AU - Hansen, Adam Espe
AU - Knudsen, Gitte Moos
PY - 2020
Y1 - 2020
N2 - Endogenous serotonin (5-HT) release can be measured noninvasively using positron emission tomography (PET) imaging in combination with certain serotonergic radiotracers. This allows us to investigate effects of pharmacological and nonpharmacological interventions on brain 5-HT levels in living humans. Here, we study the neural responses to a visual stimulus using simultaneous PET/MRI. In a cross-over design, 11 healthy individuals were PET/MRI scanned with the 5-HT(1B)receptor radioligand [C-11]AZ10419369, which is sensitive to changes in endogenous 5-HT. During the last part of the scan, participants either viewed autobiographical images with positive valence (n= 11) or kept their eyes closed (n= 7). The visual stimuli increased cerebral blood flow (CBF) in the occipital cortex, as measured with pseudo-continuous arterial spin labeling. Simultaneously, we found decreased 5-HT(1B)receptor binding in the occipital cortex (-3.6 +/- 3.6%), indicating synaptic 5-HT release. Using a linear regression model, we found that the change in 5-HT1B receptor binding was significantly negatively associated with change in CBF in the occipital cortex (p= .004). For the first time, we here demonstrate how cerebral 5-HT levels change in response to nonpharmacological stimuli in humans, as measured with PET. Our findings more directly support a link between 5-HT signaling and visual processing and/or visual attention.
AB - Endogenous serotonin (5-HT) release can be measured noninvasively using positron emission tomography (PET) imaging in combination with certain serotonergic radiotracers. This allows us to investigate effects of pharmacological and nonpharmacological interventions on brain 5-HT levels in living humans. Here, we study the neural responses to a visual stimulus using simultaneous PET/MRI. In a cross-over design, 11 healthy individuals were PET/MRI scanned with the 5-HT(1B)receptor radioligand [C-11]AZ10419369, which is sensitive to changes in endogenous 5-HT. During the last part of the scan, participants either viewed autobiographical images with positive valence (n= 11) or kept their eyes closed (n= 7). The visual stimuli increased cerebral blood flow (CBF) in the occipital cortex, as measured with pseudo-continuous arterial spin labeling. Simultaneously, we found decreased 5-HT(1B)receptor binding in the occipital cortex (-3.6 +/- 3.6%), indicating synaptic 5-HT release. Using a linear regression model, we found that the change in 5-HT1B receptor binding was significantly negatively associated with change in CBF in the occipital cortex (p= .004). For the first time, we here demonstrate how cerebral 5-HT levels change in response to nonpharmacological stimuli in humans, as measured with PET. Our findings more directly support a link between 5-HT signaling and visual processing and/or visual attention.
KW - [11C]AZ10419369
KW - 5-HT
KW - 5-HT1B receptor
KW - simultaneous PET/MR
KW - visual stimulation
KW - 5-HT1B RECEPTOR-BINDING
KW - REFERENCE TISSUE MODEL
KW - NEURONAL RESPONSES
KW - IN-VIVO
KW - BRAIN
KW - PET
KW - INHIBITION
KW - QUANTIFICATION
KW - VALIDATION
KW - MODULATION
U2 - 10.1002/hbm.25156
DO - 10.1002/hbm.25156
M3 - Journal article
C2 - 32813903
VL - 41
SP - 4753
EP - 4763
JO - Human Brain Mapping
JF - Human Brain Mapping
SN - 1065-9471
IS - 16
ER -
ID: 247684211