Variance decomposition of apolipoproteins and lipids in Danish twins.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
OBJECTIVE: Twin studies are used extensively to decompose the variance of a trait, mainly to estimate the heritability of the trait. A second purpose of such studies is to estimate to what extent the non-genetic variance is shared or specific to individuals. To a lesser extent the twin studies have been used in bivariate or multivariate analysis to elucidate common genetic factors to two or more traits. METHODS AND RESULTS: In the present study the variances of traits related to lipid metabolism is decomposed in a relatively large Danish twin population, including bivariate analysis to detect possible common genetic factors of the traits. CONCLUSIONS: The heritabilities of apolipoprotein B and E, cholesterol, LDL, and high density lipoprotein (HDL) were significant in the general population, although gender-specific levels and significance were detected. Heritabilities of apolipoprotein A1, triglycerides, and very low density protein (VLDL) were only significant when the population was stratified according to gender.
Udgivelsesdato: 2007-Mar
Udgivelsesdato: 2007-Mar
Originalsprog | Engelsk |
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Tidsskrift | Atherosclerosis |
Vol/bind | 191 |
Udgave nummer | 1 |
Sider (fra-til) | 40-47 |
Antal sider | 7 |
ISSN | 0021-9150 |
DOI | |
Status | Udgivet - 2007 |
ID: 4034587