Urinary 1-hydroxypyrene, a PAH biomarker in foundry workers

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Urinary 1-hydroxypyrene, a PAH biomarker in foundry workers. / Omland, Øyvind; Sherson, D; Hansen, Åse Marie; Sigsgaard, Torben; Autrup, H; Overgaard, E.

I: Cancer Detection and Prevention, Bind 20, Nr. 1, 1996, s. 57-62.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Omland, Ø, Sherson, D, Hansen, ÅM, Sigsgaard, T, Autrup, H & Overgaard, E 1996, 'Urinary 1-hydroxypyrene, a PAH biomarker in foundry workers', Cancer Detection and Prevention, bind 20, nr. 1, s. 57-62.

APA

Omland, Ø., Sherson, D., Hansen, Å. M., Sigsgaard, T., Autrup, H., & Overgaard, E. (1996). Urinary 1-hydroxypyrene, a PAH biomarker in foundry workers. Cancer Detection and Prevention, 20(1), 57-62.

Vancouver

Omland Ø, Sherson D, Hansen ÅM, Sigsgaard T, Autrup H, Overgaard E. Urinary 1-hydroxypyrene, a PAH biomarker in foundry workers. Cancer Detection and Prevention. 1996;20(1):57-62.

Author

Omland, Øyvind ; Sherson, D ; Hansen, Åse Marie ; Sigsgaard, Torben ; Autrup, H ; Overgaard, E. / Urinary 1-hydroxypyrene, a PAH biomarker in foundry workers. I: Cancer Detection and Prevention. 1996 ; Bind 20, Nr. 1. s. 57-62.

Bibtex

@article{340938812ea44d099df51855ffee9b70,
title = "Urinary 1-hydroxypyrene, a PAH biomarker in foundry workers",
abstract = "Exposure to PAH in foundry workers has been studied by urinary 1-hydroxypyrene (HPU) levels, quantitatively measured by reversed phase HPLC. Seventy male foundry workers and 68 matched controls were investigated. Polycyclic aromatic hydrocarbon (PAH) exposure was defined by 17 breathing zone hygienic samples, consisting of 16 selected PAH compounds. Mean total PAH concentration (SD) was 10.40 (4.04) mu g/m3. A multiple regression model of tobacco consumption, age, airborne PAH-exposure and foundry work on log HPU showed a significant correlation, p <0.001, r2 = 0.69. Only foundry work (p <0.0001) and airborne PAH exposure (p = 0.0478) contributed significantly to the model. These data suggest that HPU is a sensitive biomarker for low-dose PAH exposure.",
keywords = "Adult, Aged, Air Pollutants, Occupational, Biological Markers, Chromatography, High Pressure Liquid, Humans, Industry, Male, Middle Aged, Mutagens, Occupational Exposure, Polycyclic Hydrocarbons, Aromatic, Pyrenes",
author = "{\O}yvind Omland and D Sherson and Hansen, {{\AA}se Marie} and Torben Sigsgaard and H Autrup and E Overgaard",
year = "1996",
language = "English",
volume = "20",
pages = "57--62",
journal = "Cancer Detection and Prevention",
issn = "0361-090X",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Urinary 1-hydroxypyrene, a PAH biomarker in foundry workers

AU - Omland, Øyvind

AU - Sherson, D

AU - Hansen, Åse Marie

AU - Sigsgaard, Torben

AU - Autrup, H

AU - Overgaard, E

PY - 1996

Y1 - 1996

N2 - Exposure to PAH in foundry workers has been studied by urinary 1-hydroxypyrene (HPU) levels, quantitatively measured by reversed phase HPLC. Seventy male foundry workers and 68 matched controls were investigated. Polycyclic aromatic hydrocarbon (PAH) exposure was defined by 17 breathing zone hygienic samples, consisting of 16 selected PAH compounds. Mean total PAH concentration (SD) was 10.40 (4.04) mu g/m3. A multiple regression model of tobacco consumption, age, airborne PAH-exposure and foundry work on log HPU showed a significant correlation, p <0.001, r2 = 0.69. Only foundry work (p <0.0001) and airborne PAH exposure (p = 0.0478) contributed significantly to the model. These data suggest that HPU is a sensitive biomarker for low-dose PAH exposure.

AB - Exposure to PAH in foundry workers has been studied by urinary 1-hydroxypyrene (HPU) levels, quantitatively measured by reversed phase HPLC. Seventy male foundry workers and 68 matched controls were investigated. Polycyclic aromatic hydrocarbon (PAH) exposure was defined by 17 breathing zone hygienic samples, consisting of 16 selected PAH compounds. Mean total PAH concentration (SD) was 10.40 (4.04) mu g/m3. A multiple regression model of tobacco consumption, age, airborne PAH-exposure and foundry work on log HPU showed a significant correlation, p <0.001, r2 = 0.69. Only foundry work (p <0.0001) and airborne PAH exposure (p = 0.0478) contributed significantly to the model. These data suggest that HPU is a sensitive biomarker for low-dose PAH exposure.

KW - Adult

KW - Aged

KW - Air Pollutants, Occupational

KW - Biological Markers

KW - Chromatography, High Pressure Liquid

KW - Humans

KW - Industry

KW - Male

KW - Middle Aged

KW - Mutagens

KW - Occupational Exposure

KW - Polycyclic Hydrocarbons, Aromatic

KW - Pyrenes

M3 - Journal article

C2 - 8907204

VL - 20

SP - 57

EP - 62

JO - Cancer Detection and Prevention

JF - Cancer Detection and Prevention

SN - 0361-090X

IS - 1

ER -

ID: 48865756