Training improves oxidative capacity, but not function, in spinal muscular atrophy type III
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Training improves oxidative capacity, but not function, in spinal muscular atrophy type III. / Madsen, Karen Lindhardt; Hansen, Regitze Sølling; Preisler, Nicolai; Thøgersen, Frank; Berthelsen, Martin Peter; Vissing, John.
I: Muscle & Nerve, Bind 52, Nr. 2, 08.2015, s. 240–244.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Training improves oxidative capacity, but not function, in spinal muscular atrophy type III
AU - Madsen, Karen Lindhardt
AU - Hansen, Regitze Sølling
AU - Preisler, Nicolai
AU - Thøgersen, Frank
AU - Berthelsen, Martin Peter
AU - Vissing, John
N1 - © 2014 Wiley Periodicals, Inc.
PY - 2015/8
Y1 - 2015/8
N2 - INTRODUCTION: In this study we investigated the effect of 12 weeks of cycle ergometer training in patients with spinal muscular atrophy type III (SMA III), a hereditary motor neuron disease with progressive muscle weakness and atrophy.METHODS: Six SMA III patients and 9 healthy subjects completed a 12-week training program, performing 42 30-minute sessions exercising at 65-70% of maximal oxygen uptake (VO2max ). VO2max , muscle strength, functional tests, and self-reported activities of daily living were assessed before and after the training.RESULTS: Training induced a 27 ± 3% increase in VO2max (17 ± 2 to 21 ± 2 ml/kg/min, P < 0.001) in patients. However, fatigue was a major complaint and caused 1 patient to drop out, increased the need for sleep in 3 patients, and led to training modifications in 2 patients.CONCLUSIONS: Cycle exercise improves VO2max in SMA III without causing muscle damage, but it also induces significant fatigue. This warrants study into alternative training methods to improve exercise capacity in SMA III patients.
AB - INTRODUCTION: In this study we investigated the effect of 12 weeks of cycle ergometer training in patients with spinal muscular atrophy type III (SMA III), a hereditary motor neuron disease with progressive muscle weakness and atrophy.METHODS: Six SMA III patients and 9 healthy subjects completed a 12-week training program, performing 42 30-minute sessions exercising at 65-70% of maximal oxygen uptake (VO2max ). VO2max , muscle strength, functional tests, and self-reported activities of daily living were assessed before and after the training.RESULTS: Training induced a 27 ± 3% increase in VO2max (17 ± 2 to 21 ± 2 ml/kg/min, P < 0.001) in patients. However, fatigue was a major complaint and caused 1 patient to drop out, increased the need for sleep in 3 patients, and led to training modifications in 2 patients.CONCLUSIONS: Cycle exercise improves VO2max in SMA III without causing muscle damage, but it also induces significant fatigue. This warrants study into alternative training methods to improve exercise capacity in SMA III patients.
KW - Adult
KW - Exercise
KW - Exercise Test
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Muscle Fatigue
KW - Muscle Strength
KW - Oxygen Consumption
KW - Spinal Muscular Atrophies of Childhood
KW - Young Adult
U2 - 10.1002/mus.24527
DO - 10.1002/mus.24527
M3 - Journal article
C2 - 25418505
VL - 52
SP - 240
EP - 244
JO - Muscle & Nerve
JF - Muscle & Nerve
SN - 0148-639X
IS - 2
ER -
ID: 156086566