Toluene depresses plasma corticosterone in pregnant rats

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Toluene depresses plasma corticosterone in pregnant rats. / Hougaard, Karin S; Hansen, Åse Marie; Hass, Ulla; Lund, Søren.

I: Pharmacology & Toxicology, Bind 92, Nr. 3, 03.2003, s. 148-52.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hougaard, KS, Hansen, ÅM, Hass, U & Lund, S 2003, 'Toluene depresses plasma corticosterone in pregnant rats', Pharmacology & Toxicology, bind 92, nr. 3, s. 148-52.

APA

Hougaard, K. S., Hansen, Å. M., Hass, U., & Lund, S. (2003). Toluene depresses plasma corticosterone in pregnant rats. Pharmacology & Toxicology, 92(3), 148-52.

Vancouver

Hougaard KS, Hansen ÅM, Hass U, Lund S. Toluene depresses plasma corticosterone in pregnant rats. Pharmacology & Toxicology. 2003 mar.;92(3):148-52.

Author

Hougaard, Karin S ; Hansen, Åse Marie ; Hass, Ulla ; Lund, Søren. / Toluene depresses plasma corticosterone in pregnant rats. I: Pharmacology & Toxicology. 2003 ; Bind 92, Nr. 3. s. 148-52.

Bibtex

@article{27f0eaf72a784da1a63134d835391b35,
title = "Toluene depresses plasma corticosterone in pregnant rats",
abstract = "Combined exposure to stressors and chemicals may result in synergistic effects. The effects of prenatal exposure to the organic solvent toluene resemble those observed in offspring of gestationally stressed dams, a possible common mechanism being transfer of stress-/toluene-induced increments of corticosteroids from the maternal to the foetal compartment. Pregnant rats were subjected to either 1500 ppm toluene 6 hr/day and/or a schedule of {"}Chronic mild stress{"} during the last two weeks of gestation. Exposure to toluene was associated with reduced birth weight and lower maternal weight gain, the latter being enhanced by maternal stress. A depressant effect of toluene on maternal corticosterone was observed, hence the study does not provide immediate evidence that transfer of elevated levels of corticosterone from the maternal to the foetal compartment mediates the effects of prenatal exposure to toluene.",
keywords = "Animals, Animals, Newborn, Birth Weight, Corticosterone, Embryonic and Fetal Development, Female, Male, Maternal Exposure, Pregnancy, Pregnancy Complications, Rats, Rats, Wistar, Reproduction, Solvents, Stress, Physiological, Toluene, Weight Gain",
author = "Hougaard, {Karin S} and Hansen, {{\AA}se Marie} and Ulla Hass and S{\o}ren Lund",
year = "2003",
month = mar,
language = "English",
volume = "92",
pages = "148--52",
journal = "Pharmacology and Toxicology",
issn = "0901-9928",
publisher = "Munksgaard ",
number = "3",

}

RIS

TY - JOUR

T1 - Toluene depresses plasma corticosterone in pregnant rats

AU - Hougaard, Karin S

AU - Hansen, Åse Marie

AU - Hass, Ulla

AU - Lund, Søren

PY - 2003/3

Y1 - 2003/3

N2 - Combined exposure to stressors and chemicals may result in synergistic effects. The effects of prenatal exposure to the organic solvent toluene resemble those observed in offspring of gestationally stressed dams, a possible common mechanism being transfer of stress-/toluene-induced increments of corticosteroids from the maternal to the foetal compartment. Pregnant rats were subjected to either 1500 ppm toluene 6 hr/day and/or a schedule of "Chronic mild stress" during the last two weeks of gestation. Exposure to toluene was associated with reduced birth weight and lower maternal weight gain, the latter being enhanced by maternal stress. A depressant effect of toluene on maternal corticosterone was observed, hence the study does not provide immediate evidence that transfer of elevated levels of corticosterone from the maternal to the foetal compartment mediates the effects of prenatal exposure to toluene.

AB - Combined exposure to stressors and chemicals may result in synergistic effects. The effects of prenatal exposure to the organic solvent toluene resemble those observed in offspring of gestationally stressed dams, a possible common mechanism being transfer of stress-/toluene-induced increments of corticosteroids from the maternal to the foetal compartment. Pregnant rats were subjected to either 1500 ppm toluene 6 hr/day and/or a schedule of "Chronic mild stress" during the last two weeks of gestation. Exposure to toluene was associated with reduced birth weight and lower maternal weight gain, the latter being enhanced by maternal stress. A depressant effect of toluene on maternal corticosterone was observed, hence the study does not provide immediate evidence that transfer of elevated levels of corticosterone from the maternal to the foetal compartment mediates the effects of prenatal exposure to toluene.

KW - Animals

KW - Animals, Newborn

KW - Birth Weight

KW - Corticosterone

KW - Embryonic and Fetal Development

KW - Female

KW - Male

KW - Maternal Exposure

KW - Pregnancy

KW - Pregnancy Complications

KW - Rats

KW - Rats, Wistar

KW - Reproduction

KW - Solvents

KW - Stress, Physiological

KW - Toluene

KW - Weight Gain

M3 - Journal article

C2 - 12753431

VL - 92

SP - 148

EP - 152

JO - Pharmacology and Toxicology

JF - Pharmacology and Toxicology

SN - 0901-9928

IS - 3

ER -

ID: 48865474