The effect of obesity on early fetal growth and pregnancy duration: a cohort study
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
The effect of obesity on early fetal growth and pregnancy duration : a cohort study. / Thagaard, Ida Näslund; Krebs, Lone; Holm, Jens-Christian; Christiansen, Michael; Møller, Henrik; Lange, Theis; Larsen, Torben.
I: Journal of Maternal - Fetal & Neonatal Medicine, Bind 31, Nr. 22, 04.08.2018, s. 2941-2946.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - The effect of obesity on early fetal growth and pregnancy duration
T2 - a cohort study
AU - Thagaard, Ida Näslund
AU - Krebs, Lone
AU - Holm, Jens-Christian
AU - Christiansen, Michael
AU - Møller, Henrik
AU - Lange, Theis
AU - Larsen, Torben
PY - 2018/8/4
Y1 - 2018/8/4
N2 - OBJECTIVE: The objective of this study is to investigate the effect of maternal obesity on fetal size in first- and second-trimester pregnancies and to determine duration of pregnancy as estimated by a variety of methods.METHODS: Between 2006 and 2011, a cohort study included (n = 9055) singleton pregnancies that resulted in live birth at Holbaek Hospital in Denmark. This study recorded first- and second-trimester fetal measurements and maternal anthropometry. Characteristics considered included mother's age, parity, height, body mass index (BMI), smoking habits, and sex of child. The correlation between BMI and duration of pregnancy was analyzed by time-to-event analysis and accounted for medical intervention by censoring while correlation of BMI on fetal size was evaluated by multiple regression analysis.RESULTS: Adjusting for maternal and fetal characteristics, BMI was associated with prolonged pregnancy duration (0.20-0.22 d per kg/m(2) (standard error (SE) 0.02)) when using ultrasound and 0.26 d per kg/m(2) (SE: 0.03) when using last menstrual period. With increasing BMI, fetal biometries in first and second trimester were significantly smaller than expected (0.08 mm per kg/m(2) when measured by crown rump length (SE 0.02)).CONCLUSIONS: Maternal BMI is correlated to smaller fetal size in early pregnancy and prolongs duration of pregnancy.
AB - OBJECTIVE: The objective of this study is to investigate the effect of maternal obesity on fetal size in first- and second-trimester pregnancies and to determine duration of pregnancy as estimated by a variety of methods.METHODS: Between 2006 and 2011, a cohort study included (n = 9055) singleton pregnancies that resulted in live birth at Holbaek Hospital in Denmark. This study recorded first- and second-trimester fetal measurements and maternal anthropometry. Characteristics considered included mother's age, parity, height, body mass index (BMI), smoking habits, and sex of child. The correlation between BMI and duration of pregnancy was analyzed by time-to-event analysis and accounted for medical intervention by censoring while correlation of BMI on fetal size was evaluated by multiple regression analysis.RESULTS: Adjusting for maternal and fetal characteristics, BMI was associated with prolonged pregnancy duration (0.20-0.22 d per kg/m(2) (standard error (SE) 0.02)) when using ultrasound and 0.26 d per kg/m(2) (SE: 0.03) when using last menstrual period. With increasing BMI, fetal biometries in first and second trimester were significantly smaller than expected (0.08 mm per kg/m(2) when measured by crown rump length (SE 0.02)).CONCLUSIONS: Maternal BMI is correlated to smaller fetal size in early pregnancy and prolongs duration of pregnancy.
KW - Journal Article
U2 - 10.1080/14767058.2017.1359825
DO - 10.1080/14767058.2017.1359825
M3 - Journal article
C2 - 28738716
VL - 31
SP - 2941
EP - 2946
JO - Journal of Maternal-Fetal Medicine
JF - Journal of Maternal-Fetal Medicine
SN - 1476-7058
IS - 22
ER -
ID: 182621234