Test-retest repeatability and software reproducibility of myocardial flow measurements using rest/adenosine stress Rubidium-82 PET/CT with and without motion correction in healthy young volunteers

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Test-retest repeatability and software reproducibility of myocardial flow measurements using rest/adenosine stress Rubidium-82 PET/CT with and without motion correction in healthy young volunteers. / Byrne, Christina; Kjær, Andreas; Olsen, Naja Enevold; Forman, Julie Lyng; Hasbak, Philip.

I: Journal of Nuclear Cardiology, Bind 28, 2021, s. 2860–2871.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Byrne, C, Kjær, A, Olsen, NE, Forman, JL & Hasbak, P 2021, 'Test-retest repeatability and software reproducibility of myocardial flow measurements using rest/adenosine stress Rubidium-82 PET/CT with and without motion correction in healthy young volunteers', Journal of Nuclear Cardiology, bind 28, s. 2860–2871. https://doi.org/10.1007/s12350-020-02140-1

APA

Byrne, C., Kjær, A., Olsen, N. E., Forman, J. L., & Hasbak, P. (2021). Test-retest repeatability and software reproducibility of myocardial flow measurements using rest/adenosine stress Rubidium-82 PET/CT with and without motion correction in healthy young volunteers. Journal of Nuclear Cardiology, 28, 2860–2871. https://doi.org/10.1007/s12350-020-02140-1

Vancouver

Byrne C, Kjær A, Olsen NE, Forman JL, Hasbak P. Test-retest repeatability and software reproducibility of myocardial flow measurements using rest/adenosine stress Rubidium-82 PET/CT with and without motion correction in healthy young volunteers. Journal of Nuclear Cardiology. 2021;28:2860–2871. https://doi.org/10.1007/s12350-020-02140-1

Author

Byrne, Christina ; Kjær, Andreas ; Olsen, Naja Enevold ; Forman, Julie Lyng ; Hasbak, Philip. / Test-retest repeatability and software reproducibility of myocardial flow measurements using rest/adenosine stress Rubidium-82 PET/CT with and without motion correction in healthy young volunteers. I: Journal of Nuclear Cardiology. 2021 ; Bind 28. s. 2860–2871.

Bibtex

@article{f3349fe2a4214435979abb1df6a53329,
title = "Test-retest repeatability and software reproducibility of myocardial flow measurements using rest/adenosine stress Rubidium-82 PET/CT with and without motion correction in healthy young volunteers",
abstract = "BackgroundMyocardial flow reserve (MFR) assessment with cardiac positron emission computed tomography (PET/CT) is well established, and quantification relies on commercial software packages. However, for reliable use, repeatability and reproducibility are important. The aim of this study was therefore to investigate and compare between scans and software packages the repeatability and reproducibility of 82Rb-PET/CT estimated MFR.Methods and ResultsForty healthy volunteers completed two 82Rb-PET/CT rest and adenosine stress scans. syngo.MBF (Siemens), quantitative-gated SPECT (QGS) (Cedars-Sinai), and Corridor4DM (4DM) were used for analyses. Motion correction was available for 4DM. Fifty percent were men and age was 24 ± 4 years (mean ± SD). Repeatability of MFR varied between scans. syngo.MBF: mean difference (95% CI) 0.26 (− 0.03 to 0.54), P = 0.07, limits of agreement (LoA): − 1.43 to 1.95; QGS: 0.19 (− 0.08 to 0.46), P = 0.15, LoA: − 1.38 to 1.76; 4DM: 0.08 (− 0.17 to 0.34), P = 0.50, LoA: − 1.37 to 1.53; and 4DM motion corrected: 0.17 (− 0.17 to 0.51), P = 0.32, LoA: − 1.89 to 2.22. MFR was higher using 4DM +/− motion correction compared with syngo.MBF and QGS (all P < 0.0001). Concordance between syngo.MBF and QGS was high (P = 0.83).ConclusionsReproducibility of MFR varied for the different software. The highest concordance between MFRs was found between syngo.MBF and QGS.",
keywords = "Myocardial perfusion, Myocardial blood flow, Myocardial flow reserve, Positron emission tomography, Repeatability, Reproducibility",
author = "Christina Byrne and Andreas Kj{\ae}r and Olsen, {Naja Enevold} and Forman, {Julie Lyng} and Philip Hasbak",
year = "2021",
doi = "10.1007/s12350-020-02140-1",
language = "English",
volume = "28",
pages = "2860–2871",
journal = "Journal of Nuclear Cardiology",
issn = "1071-3581",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Test-retest repeatability and software reproducibility of myocardial flow measurements using rest/adenosine stress Rubidium-82 PET/CT with and without motion correction in healthy young volunteers

AU - Byrne, Christina

AU - Kjær, Andreas

AU - Olsen, Naja Enevold

AU - Forman, Julie Lyng

AU - Hasbak, Philip

PY - 2021

Y1 - 2021

N2 - BackgroundMyocardial flow reserve (MFR) assessment with cardiac positron emission computed tomography (PET/CT) is well established, and quantification relies on commercial software packages. However, for reliable use, repeatability and reproducibility are important. The aim of this study was therefore to investigate and compare between scans and software packages the repeatability and reproducibility of 82Rb-PET/CT estimated MFR.Methods and ResultsForty healthy volunteers completed two 82Rb-PET/CT rest and adenosine stress scans. syngo.MBF (Siemens), quantitative-gated SPECT (QGS) (Cedars-Sinai), and Corridor4DM (4DM) were used for analyses. Motion correction was available for 4DM. Fifty percent were men and age was 24 ± 4 years (mean ± SD). Repeatability of MFR varied between scans. syngo.MBF: mean difference (95% CI) 0.26 (− 0.03 to 0.54), P = 0.07, limits of agreement (LoA): − 1.43 to 1.95; QGS: 0.19 (− 0.08 to 0.46), P = 0.15, LoA: − 1.38 to 1.76; 4DM: 0.08 (− 0.17 to 0.34), P = 0.50, LoA: − 1.37 to 1.53; and 4DM motion corrected: 0.17 (− 0.17 to 0.51), P = 0.32, LoA: − 1.89 to 2.22. MFR was higher using 4DM +/− motion correction compared with syngo.MBF and QGS (all P < 0.0001). Concordance between syngo.MBF and QGS was high (P = 0.83).ConclusionsReproducibility of MFR varied for the different software. The highest concordance between MFRs was found between syngo.MBF and QGS.

AB - BackgroundMyocardial flow reserve (MFR) assessment with cardiac positron emission computed tomography (PET/CT) is well established, and quantification relies on commercial software packages. However, for reliable use, repeatability and reproducibility are important. The aim of this study was therefore to investigate and compare between scans and software packages the repeatability and reproducibility of 82Rb-PET/CT estimated MFR.Methods and ResultsForty healthy volunteers completed two 82Rb-PET/CT rest and adenosine stress scans. syngo.MBF (Siemens), quantitative-gated SPECT (QGS) (Cedars-Sinai), and Corridor4DM (4DM) were used for analyses. Motion correction was available for 4DM. Fifty percent were men and age was 24 ± 4 years (mean ± SD). Repeatability of MFR varied between scans. syngo.MBF: mean difference (95% CI) 0.26 (− 0.03 to 0.54), P = 0.07, limits of agreement (LoA): − 1.43 to 1.95; QGS: 0.19 (− 0.08 to 0.46), P = 0.15, LoA: − 1.38 to 1.76; 4DM: 0.08 (− 0.17 to 0.34), P = 0.50, LoA: − 1.37 to 1.53; and 4DM motion corrected: 0.17 (− 0.17 to 0.51), P = 0.32, LoA: − 1.89 to 2.22. MFR was higher using 4DM +/− motion correction compared with syngo.MBF and QGS (all P < 0.0001). Concordance between syngo.MBF and QGS was high (P = 0.83).ConclusionsReproducibility of MFR varied for the different software. The highest concordance between MFRs was found between syngo.MBF and QGS.

KW - Myocardial perfusion

KW - Myocardial blood flow

KW - Myocardial flow reserve

KW - Positron emission tomography

KW - Repeatability

KW - Reproducibility

U2 - 10.1007/s12350-020-02140-1

DO - 10.1007/s12350-020-02140-1

M3 - Journal article

C2 - 32390111

VL - 28

SP - 2860

EP - 2871

JO - Journal of Nuclear Cardiology

JF - Journal of Nuclear Cardiology

SN - 1071-3581

ER -

ID: 241574359